HIGH MODULUS POLYURETHANE AND POLYURETHANE/UREA COMPOSITIONS

• US 20090099600A1
• Filed: 10/03/2008
• Published: 04/16/2009
• Est. Priority Date: 10/03/2007
• Status: Active Grant

• Current Assignee: PolyNovo Biomaterials Pty Ltd. (Polynovo Ltd.)
• Original Assignee: PolyNovo Biomaterials Pty Ltd. (Polynovo Ltd.)
• Inventors: Houshyar, Shadi, Moore, Timothy Graeme, Gunatillake, Pathiraja Arachchillage, Adhikari, Raju
• Granted Patent: US 8,357,767 B2
• Time in Patent Office: Days
• US Class Current: 606/246
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: C08G 18/428 Lactides
• CPC Class Codes: C08G 18/4283 Hydroxycarboxylic acid or ester
• CPC Class Codes: C08G 18/664 with compounds of group C08G18/3203
• CPC Class Codes: C08G 18/722 Combination of two or more aliphatic and/or cycloaliphatic polyisocyanates
• CPC Class Codes: C08G 2230/00 Compositions for preparing biodegradable polymers
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

The present invention provides a polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 30% at a temperature of between 0° C. and 60° C. and at a relative humidity of between 0% and 100%.

The invention further provides uses of the compositions of the invention in biomedical vascular stents, an orthopaedic implant, a drug delivery coating or in tissue engineering.

Claims

1. A polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 30% at a temperature of between 0°

C. and 60°

C. and at a relative humidity of between 0% and 100%.

2. The polyurethane or polyurethane/urea composition of claim 1 which has an elongation at break greater than 75% at a temperature of between 0°

C. and 60°

C. and at a relative humidity of between 0% and 100%.

3. The polyurethane or polyurethane/urea composition of claim 1 which has an elongation at break greater than 150% at a temperature of between 0°

C. and 60°

C. and at a relative humidity of between 0% and 100%.

4. The polyurethane or polyurethane/urea composition of any one of claims 1 to 3 comprising at least two polyurethanes and/or polyurethane/ureas having different glass transition temperatures.

5. The polyurethane or polyurethane/urea composition of any one of claims 1 to 4 wherein the composition is derived from at least two diisocyanates at least one of the diisocyanates containing isocyanate moieties in an unsymmetric configuration.

6. The polyurethane or polyurethane/urea composition of claim 5 wherein at least one of the diisocyanates contains isocyanate moieties in a symmetric configuration.

7. The polyurethane or polyurethane/urea composition of any one of claims 1 to 4 wherein the composition is derived from at least two diisocyanates at least one of the diisocyanates containing isocyanate moieties attached to a cyclic structure.

8. The polyurethane or polyurethane/urea composition of claim 7 wherein at least one of the diisocyanates contains isocyanate moieties attached to a linear structure.

9. The polyurethane or polyurethane/urea composition of any of claims 1 to 8 additionally comprising one or more chain extenders.

10. The polyurethane or polyurethane/urea composition of claim 9 wherein at least one of the chain extenders has a hydrolysable linking group.

11. The polyurethane or polyurethane/urea composition of any of claims 1 to 10 which is biocompatible.

12. The polyurethane or polyurethane/urea composition of any of claims 1 to 11 which is biodegradable.

13. Use of a composition according to any one of claims 1-12 in a medical device, a vascular stent, an orthopaedic implant, a drug delivery coating or in tissue engineering.

14. An article of manufacture formed from the polyurethane or polyurethane/urea compositions of any of claims 1 to 12.

15. The article of claim 14 wherein the article is a medical device, an orthopaedic implant, a bone fixation device, a vascular stent, a spinal cage or a scaffold.