SOFTWARE ASSISTED METHODS FOR PROBING THE BIOCHEMICAL BASIS OF BIOLOGICAL STATES
First Claim
1. A software assisted method for identifying similarities and differences between the biochemistry of a plurality of biological states, the method comprising the steps of:
- a) providing in a storage medium a plurality of causal system models, each model representing a biological state in an animal, and comprising;
(i) nodes representative of differences in plural biological entities, actions, functional activities, or concepts in a said biological state as compared with a second biological state, and(ii) links between nodes indicative of there being a causal directionality therebetween; and
b) comparing electronically at least a portion of at least one causal system model to at least a portion of at least one other casual system model to identify similarities and differences between nodes from respective said models thereby to discern biochemical similarities and differences between said modeled biological states; and
c) causing an electronic representation of said biochemical similarities and differences between said modeled biological states to be physically stored on a computer-readable medium.
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Accused Products
Abstract
The present invention relates to computational methods, systems and apparatus useful in the identification of similarities and/or differences between a plurality of biological states, such as altered biological states in an animal (e.g., a mammal or human). Particularly, the invention relates to comparing two or more causal system models (“CSMs”) which each are indicative of a biological state, such as a disease state, a toxic state, or a drug- or therapy-induced state. The present invention also relates to generating a general CSM from a comparison of two or more other CSMs, and subsequently comparing one or more of the other CSMs to the general CSM. Either of these techniques, or a combination of the two techniques, can be used to identify unique and common features in each CSM.
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Citations
21 Claims
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1. A software assisted method for identifying similarities and differences between the biochemistry of a plurality of biological states, the method comprising the steps of:
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a) providing in a storage medium a plurality of causal system models, each model representing a biological state in an animal, and comprising; (i) nodes representative of differences in plural biological entities, actions, functional activities, or concepts in a said biological state as compared with a second biological state, and (ii) links between nodes indicative of there being a causal directionality therebetween; and b) comparing electronically at least a portion of at least one causal system model to at least a portion of at least one other casual system model to identify similarities and differences between nodes from respective said models thereby to discern biochemical similarities and differences between said modeled biological states; and c) causing an electronic representation of said biochemical similarities and differences between said modeled biological states to be physically stored on a computer-readable medium. - View Dependent Claims (2, 3, 4)
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5. A software assisted method for probing pharmacology in an animal, the method comprising the steps of:
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a) providing in a storage medium a plurality of causal system models, each model comprising a collection of nodes representative of differences in plural biological entities, actions, functional activities, or concepts in a said biological state as compared with a second biological state, and links between nodes indicative of there being a causal directionality therebetween, each model being representative of the biochemistry of an animal induced by administration to the animal of a selected molecular entity, a selected dose of a selected molecular entity, or a selected group of molecular entities; b) comparing electronically at least portions of at least two said causal system models to discern biochemical differences between the biochemical effects in the animal of different molecular entities, different doses of molecular entity, or different groups of molecular entities; and c) causing an electronic representation of the biochemical differences between the biochemical effects in the animal of different molecular entities, different doses of molecular entity, or different groups of molecular entities to be physically stored on a computer-readable medium. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for discovery by an investigator of similarities and differences between the biochemistry of a plurality of biological states, the method comprising the steps of causing a second party entity or entities to:
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a) provide in a storage medium a plurality of causal system models, each model representing a biological state in an animal, and comprising; (i) nodes representative of differences in plural biological entities, actions, functional activities, or concepts in a said biological state as compared with a second biological state, and (ii) links between nodes indicative of there being a causal directionality therebetween; and b) compare electronically at least a portion of at least one causal system model to at least a portion of at least one other casual system model to identify similarities and differences between nodes from respective said models thereby to discern biochemical similarities and differences between said modeled biological states; and c) cause an electronic representation of said biochemical similarities and differences between said modeled biological states to be physically stored on a computer-readable medium. - View Dependent Claims (21)
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20. A method for probing by an investigator pharmacology in an animal, the method comprising the steps of causing a second party entity or entities to:
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a) provide in a storage medium a plurality of causal system models, each model comprising a collection of nodes representative of differences in plural biological entities, actions, functional activities, or concepts in a said biological state as compared with a second biological state, and links between nodes indicative of there being a causal directionality therebetween, each model being representative of the biochemistry of an animal induced by administration to the animal of a selected molecular entity, a selected dose of a selected molecular entity, or a selected group of molecular entities; b) compare electronically at least portions of at least two said causal system models to discern biochemical differences between the biochemical effects in the animal of different molecular entities, different doses of molecular entity, or different groups of molecular entities; and c) cause an electronic representation of the biochemical differences between the biochemical effects in the animal of different molecular entities, different doses of molecular entity, or different groups of molecular entities to be physically stored on a computer-readable medium.
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Specification