System and Methods for Determination of Analyte Concentration Using Time Resolved Amperometry
First Claim
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1. A method for determining a concentration of an analyte, the steps comprising:
- applying a potential excitation to a fluid sample containing an analyte;
measuring a current associated with the potential excitation at a plurality of time-points; and
calculating an analyte concentration based on the measured current and a calibration curve, wherein the calibration curve is selected from a plurality of calibration curves and each calibration curve is associated with a time-segment selected from a plurality of time-segments.
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Abstract
This invention is a method for determining a concentration of an analyte. The steps include applying a potential excitation to a fluid sample containing an analyte, and measuring a current associated with the potential excitation at a plurality of time-points. The method also includes calculating an analyte concentration based on the measured current and a calibration curve, wherein the calibration curve is selected from a plurality of calibration curves and each calibration curve is associated with a time-segment selected from a plurality of time-segments.
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Citations
84 Claims
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1. A method for determining a concentration of an analyte, the steps comprising:
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applying a potential excitation to a fluid sample containing an analyte; measuring a current associated with the potential excitation at a plurality of time-points; and calculating an analyte concentration based on the measured current and a calibration curve, wherein the calibration curve is selected from a plurality of calibration curves and each calibration curve is associated with a time-segment selected from a plurality of time-segments. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for determining a concentration of an analyte, the steps comprising:
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applying a potential excitation to a fluid sample containing an analyte; measuring a first current value associated with the potential excitation at a first time-point; measuring a second current value associated with the potential excitation at a second time-point; and determining a predicted current at a future time-point, wherein the predicted current is determined using an extrapolated current decay curve based on the first and second current values; calculating an analyte concentration based on the predicted current and a calibration curve, wherein the calibration curve is selected from a plurality of calibration curves and each calibration curve is associated with a time-segment selected from a plurality of time-segments. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A system for determining an analyte concentration in a fluid sample, comprising:
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a set of electrodes configured to apply a potential excitation to a fluid sample containing an analyte; a processor configured to; measure a current associated with the potential excitation at a plurality of time-points; compare a current measured at a first time-segment to a current associated with a first target-range; if the first measured current is within the first target-range, then determine an analyte concentration based on the first measured current and a first calibration curve; and if the first measured current is outside the first target-range, then determine an analyte concentration based on a second calibration curve. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59)
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60. A system for determining an analyte concentration in a fluid sample, comprising:
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a set of electrodes configured to apply a potential excitation to a fluid sample containing an analyte; a processor configured to; measure a first current value associated with the potential excitation at a first time-point; measure a second current value associated with the potential excitation at a second time-point; determine a predicted current at a future time-point, wherein the predicted current is determined using an extrapolated current decay curve based on the first and second current values; and calculate an analyte concentration based on the predicted current and a calibration curve, wherein the calibration curve is selected from a plurality of calibration curves and each calibration curve is associated with a time-segment selected from a plurality of time-segments. - View Dependent Claims (61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83)
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84. A computer readable media, wherein the media comprises a plurality of instructions configured to direct a processor to:
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measure a current associated with a potential excitation at a plurality of time-points, wherein the potential excitation is applied to a fluid sample containing an analyte; compare a current measured at a first time-segment to a current associated with a first target-range; if the first measured current is within the first target-range, then determine an analyte concentration based on the first measured current and a first calibration curve; and if the first measured current is outside the first target-range, then determine an analyte concentration based on a second calibration curve.
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Specification