Ionizing-radiation-responsive compositions, methods, and systems

• US 20090101841A1
• Filed: 01/30/2008
• Published: 04/23/2009
• Est. Priority Date: 10/18/2007
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Ishikawa, Muriel Y., Weaver, Thomas A., Myhrvold, Nathan P., Tegreene, Clarence T., Boyden, Edward S., Jung, Edward K.Y., Whitmer, Charles, Wood, Lowell L. JR., Hyde, Roderick A., Wood, Victoria Y.H.
• Granted Patent: US 8,684,898 B2
• Time in Patent Office: Days
• US Class Current: 250/483.100
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: C09K 11/06 containing organic luminescent materials

Abstract

A method composition and system respond to ionizing, radiation to adjust biological activity. In some approaches the ionizing radiation is X-ray or extreme ultraviolet radiation that produces luminescent responses that induce biologically active responses.

Claims

1-51. -51. (canceled)

52. An ionizing-radiation-responsive composition, comprising:

a luminescent material, the luminescent material being responsive to ionizing radiation to produce optical energy in at least a first wavelength band and a second wavelength band different from the first wavelength band;

a first photosensitive biologically active material, the first photosensitive biologically active material being responsive to optical energy in the first wavelength band; and

a second photosensitive biologically active material, the second photosensitive biologically active material being responsive to optical energy in the second wavelength band.

53. The ionizing-radiation-responsive composition of claim 52, wherein the luminescent material has a first responsiveness to ionizing radiation to produce optical energy in at least the first wavelength band, the first responsiveness varying with ionizing radiation energy according to a first excitation spectrum, and further wherein the luminescent material has a second responsiveness to ionizing radiation to produce optical energy in at least the second wavelength band, the second responsiveness varying with ionizing radiation energy according to a second excitation spectrum, where at least one peak in the first excitation spectrum is substantially nonoverlapping with at least one peak in the second excitation spectrum.

54. An ionizing-radiation-responsive composition, comprising:

a first luminescent material, the first luminescent material being responsive to ionizing radiation to produce optical energy in at least a first wavelength band;

a second luminescent material, the second luminescent material being responsive to ionizing radiation to produce optical energy in at least a second wavelength band;

a first photosensitive biologically active material, the first photosensitive biologically active material being responsive to optical energy in the first wavelength band; and

a second photosensitive biologically active material, the second photosensitive biologically active material being responsive to optical energy in the second wavelength band.

55. The ionizing-radiation-responsive composition of claim 54, wherein the first luminescent material has a first responsiveness to ionizing radiation to produce optical energy in at least the first wavelength band, the first responsiveness varying with ionizing radiation energy according to a first excitation spectrum, and the second luminescent material has a second responsiveness to ionizing radiation to produce optical energy in at least the second wavelength band, the second responsiveness varying with ionizing radiation energy according to a second excitation spectrum, where at least one peak in the first excitation spectrum is substantially nonoverlapping with at least one peak in the second excitation spectrum.

56-138. -138. (canceled)

139. A method, comprising:

delivering to at least one region an ionizing-radiation-responsive composition, the ionizing-radiation-responsive composition including;

at least one luminescent material, the at least one luminescent material having a first response to ionizing radiation in at least a first ionizing radiation energy band to produce optical energy in at least a first optical wavelength band and a second response to ionizing radiation in at least a second ionizing radiation energy band to produce optical energy in at least a second optical wavelength band; and

a first photosensitive biologically active material, the first photosensitive biologically active material being responsive to optical energy in the first optical wavelength band; and

a second photosensitive biologically active material, the second photosensitive biologically active material being responsive to optical energy in the second optical wavelength band; and

irradiating at least a first portion of the at least one region with ionizing radiation in at least the first ionizing radiation energy band; and

irradiating at least a second portion of the at least one region with ionizing radiation in at least the second ionizing radiation energy band.

140-145. -145. (canceled)

146. A method, comprising:

delivering to at least one region an ionizing-radiation-responsive composition, the ionizing-radiation-responsive composition including;

a luminescent material, the luminescent material having a responsiveness to ionizing radiation to produce optical energy in at least one optical wavelength band;

wherein the responsiveness of the luminescent material varies with radiation energy according to an excitation spectrum; and

a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one optical wavelength band; and

irradiating at least a portion of the at least one region with ionizing radiation having an irradiation spectrum, wherein at least one peak in the irradiation spectrum substantially overlaps at least one peak in the excitation spectrum.

147. The method of claim 146, wherein the excitation spectrum includes at least one photoelectric absorption edge.

148. The method of claim 146, wherein a plurality of peaks in the irradiation spectrum substantially overlaps a plurality of peaks in the excitation spectrum.

149. The method of claim 148, wherein the plurality of peaks in the excitation spectrum includes a plurality of photoelectric absorption edges.

150-169. -169. (canceled)

170. A method, comprising:

delivering to at least one region a photosensitive biologically active material responsive to optical radiation in at least one optical wavelength band; and

irradiating a luminescent material in at least a portion of the at least one region with ionizing radiation having an irradiation spectrum, where the luminescent material is responsive to ionizing radiation in at least a portion of the irradiation spectrum to produce optical radiation in the at least one optical wavelength band.

171. The method of claim 170, wherein the response of the luminescent material varies with radiation energy according to an excitation spectrum, and at least one peak in the irradiation spectrum substantially overlaps at least one peak in the excitation spectrum.

172. The method of claim 170, wherein the excitation spectrum includes at least one photoelectric absorption edge.

173. The method of claim 170, wherein a plurality of peaks in the irradiation spectrum substantially overlaps a plurality of peaks in the excitation spectrum.

174. The method of claim 173, wherein the plurality of peaks in the excitation spectrum includes a plurality of photoelectric absorption edges.

175. The method of claim 170, wherein the irradiating includes a plurality of ionizing radiation beams that overlap in at least a portion of the at least one region.

176. The method of claim 170, wherein the luminescent material is endogenous to at least a portion of the at least one region.

177. The method of claim 170, further comprising:

delivering the luminescent material to at least a portion of the at least one region.

178-214. -214. (canceled)