Immunomodulatory Properties of Multipotent Adult Progenitor Cells and Uses Thereof
First Claim
1. A method of adjunctive treatment of a subject, comprising:
- administering to a subject at risk for or suffering from an immune dysfunction, by an effective route and in an effective amount to treat the immune dysfunction, cells that;
are not embryonic stem cells, embryonic germ cells, or germ cells;
can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal embryonic lineages;
do not provoke a deleterious immune response in the subject; and
are effective to treat the immune dysfunction in the subject, wherein the cells are administered adjunctively to one or more other treatments administered to the subject to treat the same thing, to treat something different, or both.
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Accused Products
Abstract
Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. The cells can modulate immune responses. As an example, the cells can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjunctively, to treat subjects. For instance, the cells can be used adjunctively for immunosuppression in transplant therapy. Methods for obtaining the cells and compositions for using them also are described.
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Citations
27 Claims
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1. A method of adjunctive treatment of a subject, comprising:
- administering to a subject at risk for or suffering from an immune dysfunction, by an effective route and in an effective amount to treat the immune dysfunction, cells that;
are not embryonic stem cells, embryonic germ cells, or germ cells;
can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal embryonic lineages;
do not provoke a deleterious immune response in the subject; and
are effective to treat the immune dysfunction in the subject, wherein the cells are administered adjunctively to one or more other treatments administered to the subject to treat the same thing, to treat something different, or both. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
- administering to a subject at risk for or suffering from an immune dysfunction, by an effective route and in an effective amount to treat the immune dysfunction, cells that;
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23. A method of adjunctive treatment of a human subject, comprising:
- administering to a subject at risk for or suffering from graft versus host or host versus graft disease, by an effective route and in an effective amount to treat said disease, human cells that;
are not embryonic stem cells, embryonic germ cells, or germ cells;
can differentiate into at least one cell type of all three of the endodermal, ectodermal, and mesodermal embryonic lineages;
do not provoke a deleterious immune response in the subject; and
are effective to treat the disease in the subject, wherein the cells are administered adjunctively to one or more other treatments administered to the subject to treat the same disease, to treat something different, or both. - View Dependent Claims (24, 25, 26, 27)
- administering to a subject at risk for or suffering from graft versus host or host versus graft disease, by an effective route and in an effective amount to treat said disease, human cells that;
Specification