METHODS OF REDUCING A VIRAL INFECTION AND KITS THEREFORE
First Claim
1. A method for treating and/or preventing a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9)-susceptible viral infection comprising increasing a PCSK9 activity and/or expression in a biological system infected by the virus, whereby the increased PCSK9 activity and/or expression treats and/or prevents the viral infection in the biological system.
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Accused Products
Abstract
A method for treating and/or preventing a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9)-susceptible viral infection comprising increasing a PCSK9 activity and/or expression in a biological system infected by the virus, whereby the increased PCSK9 activity and/or expression treats and/or prevents the viral infection in the biological system. Methods of classifying subjects, methods of screening and kits therefore.
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Citations
21 Claims
- 1. A method for treating and/or preventing a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9)-susceptible viral infection comprising increasing a PCSK9 activity and/or expression in a biological system infected by the virus, whereby the increased PCSK9 activity and/or expression treats and/or prevents the viral infection in the biological system.
- 4. A method of modulating the expression of a cellular receptor involved in viral infection at the surface of cells in a biological system, comprising modulating a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) activity and/or expression in the cells, whereby the modulating of PCSK9 activity and/or expression modulates the expression of the cellular receptor at the surface of the cells.
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9. A method of identifying an agent for treating and/or preventing proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9)-susceptible viral infection comprising:
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(a) selecting a test compound able to increase PCSK9 activity and/or expression; and (b) assaying the ability of the compound to reduce (i) the PCSK9-susceptible viral infection in a biological system in vitro; and
/or (ii) CD81 expression at the surface of cells in the biological system in vitro,wherein the ability of the compound to increase PCSK9 activity and/or expression, and to reduce (i) and/or (ii) is an indication that the test compound can treat and/or prevent the PCSK9-dependent viral infection.
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10. A method of identifying a virus, the viral infection of which is treatable and/or preventable by a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) activity and/or expression, comprising:
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(a) infecting a biological system that expresses PCSK9 with the virus, wherein a lower level of infection in the biological system that expresses the PCSK9 than that in the biological system that does not express the PCSK9 is an indication that the viral infection is treatable and/or preventable by a PCSK9 activity and/or expression. - View Dependent Claims (11)
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16. A method of evaluating the susceptibility of a subject to a viral infection comprising (i) measuring the concentration of soluble proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) in a blood sample of the subject;
- or (ii) determining whether the subject expresses a PCKS9 variant associated with a low or complete PCSK9 loss of function;
or (iii) a combination of (i) and (ii), wherein a lower amount of soluble PCSK9 in the blood sample of the subject than that in a control sample and/or a determination that the subject expresses the PCSK9 variant, is an indication that the subject is susceptible to a viral infection. - View Dependent Claims (20)
- or (ii) determining whether the subject expresses a PCKS9 variant associated with a low or complete PCSK9 loss of function;
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17. A method of classifying a subject having a viral infection comprising (i) measuring the concentration of soluble proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) in a blood sample of the subject;
- or (ii) determining whether the subject expresses a PCKS9 variant associated with a low or complete PCSK9 loss of function;
or (iii) a combination of (i) and (ii), wherein the result of the measuring step and/or of the determining step enables the classification of the subject into a subgroup.
- or (ii) determining whether the subject expresses a PCKS9 variant associated with a low or complete PCSK9 loss of function;
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18. A method of selecting a treatment for a subject having a viral infection comprising (i) measuring the concentration of soluble proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) in a blood sample of the subject;
- or (ii) determining whether the subject expresses a PCKS9 variant associated with a low or complete PCSK9 loss of function;
or (iii) a combination of (i) and (ii),wherein a concentration of the soluble PCSK9 lower in the blood sample of the subject than that in a control blood sample and/or a determination that the subject expresses the PCSK9 variant, is an indication that a PCSK9 activator may be a useful treatment for the subject.
- or (ii) determining whether the subject expresses a PCKS9 variant associated with a low or complete PCSK9 loss of function;
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19. A method of evaluating the efficacy of a treatment against a viral infection in a treated subject, comprising measuring the concentration of soluble proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) in a blood sample of the subject, wherein a concentration of soluble PCSK9 higher in the blood sample of the subject than that in a control blood sample, is an indication that the treatment is efficient.
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21. Kit comprising a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) activator, and at least one other therapeutic agent against a viral infection and/or instructions to use the activator for treating the viral infection.
Specification