DIAGNOSIS OF SEPSIS
First Claim
1. A method of predicting the development of sepsis in a test subject at risk for developing sepsis, the method comprising:
- evaluating whether a plurality of features in a biomarker profile of the test subject satisfies a first value set, wherein satisfying the first value set predicts that the test subject is likely to develop sepsis, and wherein the plurality of features are measurable aspects of a plurality of biomarkers listed in Table 1, 4, 5, 6, 7, 12, 13, 14, 15, 16, 17, 18, 19 20 and/or 21, wherein, when the plurality of biomarkers comprises complement component C3 and complement component C4, the plurality of biomarkers comprises three or more biomarkers.
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Accused Products
Abstract
Methods and apparatus for predicting the development of sepsis in a subject at risk for developing sepsis are provided. Features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods and apparatus for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods and apparatus for diagnosing sepsis in a subject are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.
52 Citations
83 Claims
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1. A method of predicting the development of sepsis in a test subject at risk for developing sepsis, the method comprising:
evaluating whether a plurality of features in a biomarker profile of the test subject satisfies a first value set, wherein satisfying the first value set predicts that the test subject is likely to develop sepsis, and wherein the plurality of features are measurable aspects of a plurality of biomarkers listed in Table 1, 4, 5, 6, 7, 12, 13, 14, 15, 16, 17, 18, 19 20 and/or 21, wherein, when the plurality of biomarkers comprises complement component C3 and complement component C4, the plurality of biomarkers comprises three or more biomarkers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 80, 81, 82, 83)
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74. A method of diagnosing sepsis in a test subject, comprising:
evaluating whether a plurality of features in a biomarker profile of the test subject satisfies a first value set, wherein satisfying the first value set predicts that the test subject is likely to develop sepsis, wherein the plurality of features correspond to a plurality of biomarkers, the plurality of biomarkers comprising at least two biomarkers listed in any one of Tables 1, 4, 5, 6, 7, 12, 13, 14, 15, 16, 17, 18, 19, 20, and 21 wherein, when the plurality of biomarkers comprises complement component C3 and complement component C4, the plurality of biomarkers comprises three or more biomarkers.
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75. A microarray comprising a plurality of probe spots, wherein at least twenty percent of the probe spots in the plurality of probe spots correspond to a plurality of biomarkers listed in Table 1, 4, 5, 6, 7, 12, 13, 14, 15, 16, 17, 18, 19, or 20.
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76. A kit for predicting the development of sepsis in a test subject, the kit comprising a plurality of antibodies that specifically bind a plurality of biomarkers listed in Table 1, 4, 5, 6, 7, 12, 13, 14, 15, 16, 17, 18, 19, or 20.
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77. A computer program product for use in conjunction with a computer system, wherein the computer program product comprises a computer readable storage medium and a computer program mechanism embedded therein, the computer program mechanism comprising:
instructions for evaluating whether a plurality of features in a biomarker profile of a test subject at risk for developing sepsis satisfies a first value set, wherein satisfying the first value set predicts that the test subject is likely to develop sepsis, and wherein the plurality of features are measurable aspects of a plurality of biomarkers, the plurality of biomarkers comprising at least two biomarkers listed in Table 1, 4, 5, 6, 7, 12, 13, 14, 15, 16, 17, 18, 19 20 and/or 21, wherein, when the plurality of biomarkers comprises complement component C3 and complement component C4, the plurality of biomarkers comprises three or more biomarkers.
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78. A computer comprising:
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a central processing unit; a memory coupled to the central processing unit, the memory storing; instructions for evaluating whether a plurality of features in a biomarker profile of a test subject at risk for developing sepsis satisfies a first value set, wherein satisfying the first value set predicts that the test subject is likely to develop sepsis, and wherein the plurality of features are measurable aspects of a plurality of biomarkers, the plurality of biomarkers comprising at least two biomarkers listed in Table 1, 4, 5, 6, 7, 12, 13, 14, 15, 16, 17, 18, 19 and/or 20, wherein, when the plurality of biomarkers comprises complement component C3 and complement component C4, the plurality of biomarkers comprises three or more biomarkers.
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79. A computer system for determining whether a subject is likely to develop sepsis, the computer system comprising:
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a central processing unit; and a memory, coupled to the central processing unit, the memory storing; instructions for obtaining a biomarker profile of a test subject, wherein said biomarker profile comprises a plurality of features and wherein the plurality of features are measurable aspects of a plurality of biomarkers, the plurality of biomarkers comprising at least two biomarkers listed in any one of Tables 1, 4, 5, 6, 7, 12, 13, 14, 15, 16, 17, 18, 19, 20, and 21, wherein, when the plurality of biomarkers comprises complement component C3 and complement component C4, the plurality of biomarkers comprises three or more biomarkers; instructions for transmitting the biomarker profile to a remote computer, wherein the remote computer includes instructions for evaluating whether the plurality of features in the biomarker profile of the test subject satisfies a first value set, wherein satisfying the first value set predicts that the test subject is likely to develop sepsis; and instructions for receiving a determination, from the remote computer, as to whether the plurality of features in the biomarker profile of the test subject satisfies the first value set; and instructions for reporting whether the plurality of features in the biomarker profile of the test subject satisfies the first value set.
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Specification