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Soluble HER2 and HER3 splice variant proteins, splice-switching oligonucleotides, and their use in the treatment of disease

  • US 20090105139A1
  • Filed: 06/06/2008
  • Published: 04/23/2009
  • Est. Priority Date: 06/06/2007
  • Status: Active Grant
First Claim
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1. An isolated, soluble, human epidermal growth factor receptor-2 (HER2) protein lacking the region encoded by exon 15 of the full-length mRNA transcript of the HER2 gene, and truncated, at its C terminus, in the region encoded by exon 16 of the HER2 transcript.

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