PROCESS FOR THE PRODUCTION OF A LOW MOLECULAR WEIGHT HEPARIN

• US 20090105194A1
• Filed: 05/09/2006
• Published: 04/23/2009
• Est. Priority Date: 05/09/2005
• Status: Abandoned Application

• Current Assignee: Hepmarin AS
• Original Assignee: Universitetet For Miljã¸- OG Biovitenskap (Kunnskapsdepartementet)
• Inventors: Odegaard, Ole Rasmus, Flengsrud, Ragnar
• Application Number:
  US11/914,086
• Publication Number:
  US 20090105194A1
• Time in Patent Office: Days
• US Class Current: 514/56
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/28 Substances of animal origin, e.g. gelatin or collagen
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 7/08 Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock artificial tears A61P27/04
• CPC Class Codes: C08B 37/0078 Degradation products

Abstract

The invention provides a process for the production of a very low molecular weight heparin (VLMWH) composition having a VLMWH content, relative to total heparin content, of at least 10% wt, said process comprising chromatographically or chemically or by filtration reducing the relative proportion of heparin having a molecular weight above 8000 Da in a heparin composition extracted from a non-mammalian, vascularised marine animal.

Claims

1. A process for the production of a very low molecular weight heparin (VLMWH) composition having a VLMWH content, relative to total heparin content, of at least 10% wt, said process comprising chromatographically or chemically or by filtration reducing the relative proportion of heparin having a molecular weight above 8000 Da in a heparin composition extracted from a non-mammalian, vascularised marine animal.

2. A process as claimed in claim 1 for the production of a VLMWH composition having a VLMWH content, relative to total heparin content, of at least 20% wt.

3. A process as claimed in claim 1 wherein the relative proportion of heparin having a molecular weight above 3000 Da is reduced.

4. A process as claimed in claim 1 performed on a heparin composition extracted from post muscle-removal fish waste.

5. A process as claimed in claim 4 performed on salmon waste.

6. A process as claimed in claim 1 performed chromatographically.

11. A human foodstuff comprising a composition produced by the process of claim 1.

7. A non-mammalian marine animal very low molecular weight heparin (VLMWH) composition having a VLMWH content, relative to total heparin content, of at least 10% wt., optionally containing a physiologically acceptable carrier or excipient and/or a drug substance, and optionally coated onto a substrate.

8. A composition as claimed in claim 7 having a VLMWH content, relative to total heparin content, of at least 20% wt.

10. A human foodstuff comprising a composition according to claim 7.

9. (canceled)