Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-Compounds and the Use Thereof for Producing Drugs

• US 20090105290A1
• Filed: 06/27/2006
• Published: 04/23/2009
• Est. Priority Date: 06/27/2005
• Status: Active Grant

• Current Assignee: Grunenthal GMBH (Grünenthal Pharma GmbH & Co. KG)
• Original Assignee: Grunenthal GMBH (Grünenthal Pharma GmbH & Co. KG)
• Inventors: Przewosny, Micheal, Sundermann, Bernd, Sundermann, Corinna
• Granted Patent: US 8,153,795 B2
• Time in Patent Office: Days
• US Class Current: 514/278
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/12 Antidiarrhoeals
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 11/14 Antitussive agents
• CPC Class Codes: A61P 15/02 for disorders of the vagina
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/14 for treating abnormal movements, e.g. chorea, dyskinesia
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 25/32 Alcohol-abuse
• CPC Class Codes: A61P 25/34 Tobacco-abuse
• CPC Class Codes: A61P 25/36 Opioid-abuse
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/04 : Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/10 : Antioedematous agents; Diuretics
• CPC Class Codes: A61P 7/12 : Antidiuretics, e.g. drugs for diabetes insipidus ADH A61P5/10
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 498/10 : Spiro-condensed systems

Abstract

The present invention relates to substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments.

Claims

1-23. -23. (canceled)

24. A substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one compound corresponding to formula I

wherein

n is 1, 2, 3, 4 or 5;

R¹ denotes an optionally substituted 6- or 10-membered aryl group or an optionally substituted 5- to 14-membered heteroaryl group, wherein the aryl or heteroaryl group optionally may be fused with a saturated or unsaturated, optionally substituted mono- or bicyclic ring system;

R² denotes

—

C(═

S)—

NH—

R³;

—

C(═

O)—

NH—

R⁴;

—

S(═

O)₂—

R⁵;

—

(CH₂)—

C(═

O)—

NH—

R⁶;

—

(CH₂)-D_aa-(CH₂)_bb-E_cc-(CH₂)_dd—

R⁷, wherein

aa=0 or 1;

bb=0, 1 or 2;

cc=0 or 1;

dd=0 or 1; and

the sum of aa and cc does not equal 0; and

D and E each independently denote O, S, NH, N(CH₃), N(C₂H₅) or N[CH(CH₃)₂];

—

C(═

O)—

R⁸, or

—

S(═

O)₂—

NR⁹R¹⁰;

R³ denotes

—

(CHR¹¹)—

(CH₂)_w—

C(═

O)—

O—

R¹², wherein w=0 or 1;

—

(CHR¹³)—

(CH₂)_a—

K_b—

(CH₂)_c-L_d-R¹⁴, wherein

a=0, 1 or 2;

b=0 or 1;

c=0, 1 or 2;

d=0 or 1, and

K and L each independently denote O, S, NH, N(CH₃), N(C₂H₅) or N[CH(CH₃)₂];

a linear or branched, saturated or unsaturated, optionally substituted C_1-10 aliphatic group;

an unsaturated or saturated, optionally substituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic group which optionally may be bridged with 1 or 2 linear or branched, optionally substituted C_1-5 alkylene groups or fused with a saturated, unsaturated or aromatic, optionally substituted mono- or bicyclic ring system, or both;

an optionally substituted 6- or 10-membered aryl group;

or

an optionally substituted 5- to 14-membered heteroaryl group, wherein the aryl or heteroaryl group optionally may be fused with a saturated or unsaturated, optionally substituted mono- or bicyclic ring system;

R⁴ denotes

—

(CHR¹⁵)—

(CH₂)_e-M_f-(CH₂)_g—

P_h—

R¹⁶, wherein

e=0, 1 or 2;

f=0 or 1;

g=0, 1 or 2;

h=0 or 1; and

M and P each independently denote O, S, NH, N(CH₃), N(C₂H₅) or N[CH(CH₃)₂];

a linear or branched, saturated or unsaturated, optionally substituted C_1-10 aliphatic group;

an unsaturated or saturated, optionally substituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic group which optionally may be bridged with 1 or 2 linear or branched, optionally substituted C_1-5 alkylene groups or fused with a saturated, unsaturated or aromatic, optionally substituted mono- or bicyclic ring system, or both;

or

an optionally substituted 6- or 10-membered aryl group or optionally substituted 5- to 14-membered heteroaryl group, wherein said aryl or heteroaryl group optionally may be fused with a saturated or unsaturated, optionally substituted mono- or bicyclic ring system;

R⁵ denotes

—

(CHR¹⁷)—

(CH₂)_k-Q_l-(CH₂)_m-T_o-R¹⁸, wherein

k=0, 1 or 2;

l=0 or 1;

m=0, 1 or 2;

o=0 or 1; and

Q and T each independently denote O, S, NH, N(CH₃), N(C₂H₅) or N[CH(CH₃)₂];

a linear or branched, saturated or unsaturated, optionally substituted C_1-10 aliphatic group;

an unsaturated or saturated, optionally substituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic group which optionally may be bridged with 1 or 2 linear or branched, optionally substituted C_1-5 alkylene groups or fused with a saturated, unsaturated or aromatic, optionally substituted mono- or bicyclic ring system, or both;

or

an optionally substituted 6- or 10-membered aryl group or optionally substituted 5- to 14-membered heteroaryl group, wherein the aryl or heteroaryl group optionally may be fused with a saturated or unsaturated, optionally substituted mono- or bicyclic ring system;

R⁶ denotes

a linear or branched, saturated or unsaturated, optionally substituted C_1-10 aliphatic group;

an unsaturated or saturated, optionally substituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic group which optionally may be bridged with 1 or 2 linear or branched, optionally substituted C_1-5 alkylene groups or fused with a saturated, unsaturated or aromatic, optionally substituted mono- or bicyclic ring system, or both;

an optionally substituted 6- or 10-membered aryl group or optionally substituted 5- to 14-membered heteroaryl group, wherein the aryl or heteroaryl group optionally may be fused with a saturated or unsaturated, optionally substituted mono- or bicyclic ring system;

R⁷ denotes

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl and dithiolanyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃ and —

S(═

O)₂—

NH₂;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, —

S(═

O)₂—

NH-phenyl, phenyl and benzyl, wherein the cyclic moiety of the groups —

S(═

O)₂—

NH-phenyl, phenyl and benzyl optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl;

R⁸ denotes

—

(CHR¹⁹)—

V_p—

(CH₂)_q—

(CH₂)_r—

W_s—

R²⁰, wherein

p=0 or 1;

q=0, 1 or 2;

r=0, 1 or 2;

s=0 or 1; and

V and W each independently denote O, S, NH, N(CH₃), N(C₂H₅) or N[CH(CH₃)₂];

—

(CH═

CH)—

R²¹;

—

(CR²²R²³)—

Y_t—

(CR²⁴R²⁵)_u—

(CH₂)_v—

C(═

O)—

OR²⁶, wherein

t=0 or 1,

u=0 or 1;

v=0 or 1, and

Y denotes O, S, NH, N(CH₃), N(C₂H₅) or N[CH(CH₃)₂];

—

(CHR²⁷)—

O—

C(═

O)—

R²⁸;

—

CH[(CH₂)R²⁹][NH—

S(═

O)₂—

R³⁰];

—

CH[(CH₂)R³¹][NH—

C(═

O)—

O—

R³²];

a linear or branched, saturated or unsaturated, optionally substituted C_1-10 aliphatic group;

an unsaturated or saturated, optionally substituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic group which optionally may be bridged with 1 or 2 linear or branched, optionally substituted C_1-5 alkylene groups, or fused with a saturated, unsaturated or aromatic, optionally substituted mono- or bicyclic ring system, or both;

or

an optionally substituted 6- or 10-membered aryl group or optionally substituted 5- to 14-membered heteroaryl group, wherein the aryl or heteroaryl group optionally may be fused with a saturated or unsaturated, optionally substituted mono- or bicyclic ring system;

R⁹ and R¹⁰ each independently denote a linear or branched, saturated or unsaturated, optionally substituted C_1-10 aliphatic group;

R¹¹, R¹³, R¹⁵, R¹⁷, R¹⁹, R²², R²³, R²⁴, R²⁵ and R²⁶ each independently denote a hydrogen or a linear or branched, saturated or unsaturated, optionally substituted C_1-10 aliphatic group;

R¹², R²⁸ and R³² each independently denote a linear or branched, saturated or unsaturated, optionally substituted C_1-10 aliphatic group;

R¹⁴, R¹⁶, R¹⁸ and R²⁰ each independently denote

a linear or branched, saturated or unsaturated, optionally substituted C_1-10 aliphatic group;

an unsaturated or saturated, optionally substituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic group which optionally may be bridged with 1 or 2 linear or branched, optionally substituted C_1-5 alkylene groups, or fused with a saturated, unsaturated or aromatic, optionally substituted mono- or bicyclic ring system, or both;

or

an optionally substituted 6- or 10-membered aryl group or optionally substituted 5- to 14-membered heteroaryl group, wherein the aryl or heteroaryl group optionally may be fused with a saturated or unsaturated, optionally substituted mono- or bicyclic ring system; and

R²¹, R²⁷, R²⁹, R³⁰ and R³¹ each independently denote

an unsaturated or saturated, optionally substituted 3-, 4-, 5-, 6-, 7-, 8- or 9-membered cycloaliphatic group which optionally may be bridged with 1 or 2 linear or branched, optionally substituted C_1-5 alkylene groups, or fused with a saturated, unsaturated or aromatic, optionally substituted mono- or bicyclic ring system, or both;

or

an optionally substituted 6- or 10-membered aryl group or optionally substituted 5- to 14-membered heteroaryl group, wherein the aryl or heteroaryl group optionally may be fused with a saturated or unsaturated, optionally substituted mono- or bicyclic ring system;

wherein

the above-stated C_1-10 aliphatic groups each independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

the above-stated cycloaliphatic groups each independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

C_1-5-alkyl, —

NH₂, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

SH, —

S—

C_1-5-alkyl, —

C_1-5-alkyl, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

C_1-5-alkyl, —

(CH₂)—

C(═

O)—

O—

C_1-5-alkyl, —

O—

C(═

O)—

C_1-5-alkyl, —

NH—

C_1-5-alkyl, —

N(—

C_1-5-alkyl)₂, —

NH-phenyl, —

NH-pyridinyl, —

N(—

C_1-5-alkyl)-phenyl, —

N(—

C_1-5-alkyl)-pyridinyl, —

NH—

C(═

O)—

O—

C_1-5-alkyl, —

C(═

O)—

H, —

C(═

O)—

C_1-5-alkyl, —

C(═

O)—

C_1-5-perfluoroalkyl, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

C_1-5-alkyl, C(═

O)—

N—

(—

C_1-5-alkyl)₂, —

S(═

O)₂—

C_1-5-alkyl, —

S(═

O)₂-phenyl, —

NH—

S(═

O)₂—

C_1-5-alkyl, —

S(═

O)₂—

NH—

C_1-5-alkyl, —

S(═

O)₂—

NH₂, —

S(═

O)₂—

NH-phenyl, cyclohexyl, cyclopentyl, pyridinyl, [1,2,5]-thiadiazolyl, pyridazinyl, —

(CH₂)-benzo[b]furanyl, —

O-phenyl, —

O-benzyl, phenyl and benzyl, wherein the cyclic moiety of the groups —

S(═

O)₂—

NH-phenyl, —

NH-phenyl, —

NH-pyridinyl, —

N(—

C_1-5-alkyl)-phenyl, —

N(—

C_1-5-alkyl)-pyridinyl, pyridinyl, cyclopentyl, [1,2,5]-thiadiazolyl, cyclohexyl, pyridazinyl, —

S(═

O)₂-phenyl, —

O-phenyl, —

O-benzyl, phenyl, —

(CH₂)-benzo[b]furanyl and benzyl optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

CN, —

NO₂, —

C_1-5-alkyl, —

O—

C_1-5-alkyl, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl, and

comprise 1, 2, 3, 4 or 5 heteroatom(s) mutually independently selected from the group consisting of oxygen, nitrogen and sulfur;

the above-stated C_1-5-alkylene groups each independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

the rings of the above-stated mono- or polycyclic ring systems each independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

C_1-5-alkyl, —

NH₂, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

SH, —

S—

C_1-5-alkyl, —

C_1-5-alkyl, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH;

—

C(═

O)—

O—

C_1-5-alkyl, —

(CH₂)—

C(═

O)—

O—

C_1-5-alkyl, —

O—

C(═

O)—

C_1-5-alkyl, —

NH—

C_1-5-alkyl, —

N(—

C_1-5-alkyl)₂, —

NH-phenyl, —

NH-pyridinyl, —

N(—

C_1-5-alkyl)-phenyl, —

N(—

C_1-5-alkyl)-pyridinyl, —

NH—

C(═

O)—

O—

C_1-5-alkyl, —

C(═

O)—

H, —

C(═

O)—

C_1-5-alkyl, —

C(═

O)—

C_1-5-perfluoroalkyl, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

C_1-5-alkyl, C(═

O)—

N—

(—

C_1-5-alkyl)₂, —

S(═

O)₂—

C_1-5-alkyl, —

S(═

O)₂-phenyl, —

NH—

S(═

O)₂—

C_1-5-alkyl, —

S(═

O)₂—

NH—

C_1-5-alkyl, —

S(═

O)₂—

NH₂, —

S(═

O)₂—

NH-phenyl, cyclohexyl, cyclopentyl, pyridinyl, [1,2,5]-thiadiazolyl, pyridazinyl, —

(CH₂)-benzo[b]furanyl, —

O-phenyl, —

O-benzyl, phenyl and benzyl, wherein the cyclic moiety of the groups —

S(═

O)₂—

NH-phenyl, —

NH-phenyl, —

NH-pyridinyl, —

N(—

C_1-5-alkyl)-phenyl, —

N(—

C_1-5-alkyl)-pyridinyl, pyridinyl, cyclopentyl, [1,2,5]-thiadiazolyl, cyclohexyl, pyridazinyl, —

S(═

O)₂-phenyl, —

O-phenyl, —

O-benzyl, phenyl, —

(CH₂)-benzo[b]furanyl and benzyl optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

CN, —

NO₂, —

C_1-5-alkyl, —

O—

C_1-5-alkyl, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl;

the rings of the above-stated mono- or bicyclic ring systems are each independently 5-, 6- or 7-membered and each independently may optionally comprise as ring member(s), 1, 2, 3, 4 or 5 heteroatom(s) independently selected from the group consisting of oxygen, nitrogen and sulfur;

the above-stated aryl or heteroaryl groups each independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

C_1-5-alkyl, —

NH₂, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

C_1-5-alkyl, —

C_1-10-alkyl, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

C_1-5-alkyl, —

(CH₂)—

C(═

O)—

O—

C_1-5-alkyl, —

O—

C(═

O)—

C_1-5-alkyl, —

NH—

C_1-5-alkyl, —

N(—

C_1-5-alkyl)₂, —

NH—

C(═

O)—

O—

C_1-5-alkyl, —

NH—

C(═

O)—

C_1-5-alkyl, —

C(═

O)—

H, —

C(═

O)—

C_1-5-alkyl, —

C(═

O)—

C_1-5-perfluoroalkyl, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

C_1-5-alkyl, —

C(═

O)—

N—

(—

C_1-5-alkyl)₂, —

S(═

O)₂—

C_1-5-alkyl, —

S(═

O)₂-phenyl, —

NH—

S(═

O)₂—

C_1-5-alkyl, —

S(═

O)₂—

NH—

C_1-5-alkyl, —

S(═

O)₂—

NH₂, —

S(═

O)₂—

NH-phenyl, cyclohexyl, cyclopentyl, pyridinyl, pyridazinyl, —

(CH₂)-benzo[b]furanyl, —

O-phenyl, —

O-benzyl, phenyl and benzyl, wherein the cyclic moiety of the groups pyridinyl, cyclopentyl, cyclohexyl, pyridazinyl, —

S(═

O)₂-phenyl, —

S(═

O)₂—

NH-phenyl, —

O-phenyl, —

O-benzyl, phenyl, —

(CH₂)-benzo[b]furanyl and benzyl optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, —

C_1-5-alkyl, —

O—

C_1-5-alkyl, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl; and

the above-stated heteroaryl groups each independently may optionally comprise as ring member(s), 1, 2, 3, 4 or 5 heteroatom(s) independently selected from the group consisting of oxygen, nitrogen and sulfur;

or a pharmaceutically acceptable salt or solvate thereof.

25. A compound as claimed in claim 24, wherein said compound contains at least one chiral carbon atom and is present in the form of an isolated or purified stereoisomer.

26. A compound as claimed in claim 24, wherein said compound contains at least one chiral carbon atom and is present in the form of a mixture of stereoisomers in any mixing ratio.

27. A compound as claimed in claim 26, wherein said compound is present in the form of a racemic mixture.

28. A compound as claimed in claim 24, wherein

R¹ denotes a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, benzo[2,1,3]thiadiazolyl, [1,2,3]-benzothiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, [3,4]-dihydro-2H-1,4-benzoxazinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group may in optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, phenyl and benzyl, wherein the cyclic moiety of each phenyl or benzyl group independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

29. A compounds as claimed in claim 24, wherein

R² denotes —

C(═

S)—

NH—

R³;

—

C(═

O)—

NH—

R⁴;

—

S(═

O)₂—

R⁵;

—

(CH₂)—

C(═

O)—

NH—

R⁶;

—

(CH₂)—

O—

R⁷, —

(CH₂)—

S—

R⁷, —

(CH₂)—

NH—

R⁷, —

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

(CH₂)—

O—

R⁷, —

(CH₂)—

(CH₂)—

S—

R⁷, —

(CH₂)—

NH—

R⁷, —

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

O—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

S—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

NH—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

O—

(CH₂)—

R⁷, —

(CH₂)—

S—

(CH₂)—

R⁷;

—

(CH₂)—

NH—

(CH₂)—

R⁷;

—

C(═

O)—

R⁸ or —

S(═

O)₂—

NR⁹R¹⁰.

30. A compound as claimed in claim 24, wherein

R³ denotes

—

(CHR¹¹)—

C(═

O)—

O—

R¹² or —

(CHR¹¹)—

(CH₂)—

C(═

O)—

O—

R¹²;

—

(CHR¹³)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

R¹⁴, —

(CHR¹³)—

O—

R¹⁴, —

(CHR¹³)—

S—

R¹⁴, —

(CHR¹³)—

NH—

R¹⁴, —

(CHR¹³)—

N(CH₃)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

O—

R¹⁴, —

(CHR¹³)—

(CH₂)—

S—

R¹⁴, —

(CHR¹³)—

NH—

R¹⁴, —

(CHR¹³)—

N(CH₃)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

O—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

S—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

NH—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

N(CH₃)—

R¹⁴, —

(CHR¹³)—

O—

(CH₂)—

R¹⁴, —

(CHR¹³)—

S—

(CH₂)—

R¹⁴ or —

(CHR¹³)—

NH—

(CH₂)—

R¹⁴;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl and dithiolanyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃ and —

S(═

O)₂—

NH₂;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

CH₃, —

S—

C₂Hs, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, phenyl and benzyl, wherein the cyclic moiety of each phenyl or benzyl group independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

31. A compound as claimed in claim 24, wherein

R⁴ denotes

—

(CHR¹⁵)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

R¹⁶, —

(CHR¹⁵)—

O—

R¹⁶, —

(CHR¹⁵)—

S—

R¹⁶, —

(CHR¹⁵)—

NH—

R¹⁶, —

(CHR¹⁵)—

N(CH₃)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

O—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

S—

R¹⁶, —

(CHR¹⁵)—

NH—

R¹⁶, —

(CHR¹⁵)—

N(CH₃)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

O—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

S—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

NH—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

N(CH₃)—

R¹⁶, —

(CHR¹⁵)—

O—

(CH₂)—

R¹⁶, —

(CHR¹⁵)—

S—

(CH₂)—

R¹⁶ or —

(CHR¹⁵)—

NH—

(CH₂)—

R¹⁶;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl and dithiolanyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃ and —

S(═

O)₂—

NH₂;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein the said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, phenyl and benzyl, wherein the cyclic moiety of each phenyl or benzyl group independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

32. A compound as claimed in claim 24, wherein

R⁵ denotes

—

(CHR¹⁷)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

R¹⁸, —

(CHR¹⁷)—

O—

R¹⁸, —

(CHR¹⁷)—

S—

R¹⁸, —

(CHR¹⁷)—

NH—

R¹⁸, —

(CHR¹⁷)—

N(CH₃)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

O—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

S—

R¹⁸, —

(CHR¹⁷)—

NH—

R¹⁸, —

(CHR¹⁷)—

N(CH₃)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

O—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

S—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

NH—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

N(CH₃)—

R¹⁸, —

(CHR¹⁷)—

O—

(CH₂)—

R¹⁸, —

(CHR¹⁷)—

S—

(CH₂)—

R¹⁸ or —

(CHR¹⁷)—

NH—

(CH₂)—

R¹⁸;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl and dithiolanyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃ and —

S(═

O)₂—

NH₂;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, phenyl and benzyl, wherein the cyclic moiety of each phenyl or benzyl group independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

33. A compound as claimed in claim 24, wherein

R⁶ denotes

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl and dithiolanyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃ and —

S(═

O)₂—

NH₂;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, —

S(═

O)₂—

NH-phenyl, phenyl and benzyl, wherein in each case the cyclic moiety of the groups —

S(═

O)₂—

NH-phenyl, phenyl and benzyl may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

34. A compound as claimed in claim 24 wherein

R⁸ denotes

—

(CHR¹⁹)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

O—

R²⁰, —

(CHR¹⁹)—

S—

R²⁰, —

(CHR¹⁹)—

NH—

R²⁰, —

(CHR¹⁹)—

N(CH₃)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

S—

R²⁰, —

(CHR¹⁹)—

NH—

R²⁰, —

(CHR¹⁹)—

N(CH₃)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

S—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

NH—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

N(CH₃)—

R²⁰, —

(CHR¹⁹)—

O—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

S—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

NH—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

O—

(CH₂)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

O—

(CH₂)—

(CH₂)—

S—

R²⁰ or —

(CHR¹⁹)—

S—

(CH₂)—

(CH₂)—

S—

R²⁰;

—

(CH═

CH)—

R²¹;

—

(CR²²R²³)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

(CH₂)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

O(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

S—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶ or denotes —

(CR²²R²³)—

NH—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶;

—

(CHR²⁷)—

O—

C(═

O)—

R²⁸;

—

CH[(CH₂)R²⁹][NH—

S(═

O)₂—

R³⁰];

—

CH[(CH₂)R³¹][NH—

C(═

O)—

O—

R³²];

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl, dithiolanyl, adamantyl and bicyclo[2.2.1]heptyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

OH, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, phenyl and —

S(═

O)₂—

NH₂;

wherein the phenyl group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃ and —

O—

CH₂—

CH₂—

CH₂—

CH₃;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, benzo[2,1,3]thiadiazolyl, [1,2,3]-benzothiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

N—

CH₃, —

S(═

O)₂—

NH₂, —

S(═

O)₂—

NH-phenyl, phenyl, —

O-phenyl, —

O-benzyl and benzyl, wherein the cyclic moiety of the groups —

S(═

O)₂—

NH-phenyl, phenyl, —

O-phenyl, —

O-benzyl and benzyl optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

35. A compound as claimed in claim 24 wherein

R⁹ and R¹⁰ each independently denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl.

36. A compound as claimed in claim 24 wherein

R¹¹, R¹³, R¹⁵, R¹⁷, R¹⁹, R²², R²³, R²⁴, R²⁵ and R²⁶ each independently denote hydrogen or a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl.

37. A compound as claimed in claim 24 wherein

R¹², R²⁸ and R³² each independently denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl.

38. A compound as claimed in claim 24 wherein

R¹⁴, R¹⁶, R¹⁸ and R²⁰ each independently denote

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl, dithiolanyl, adamantyl and bicyclo[2.2.1]heptyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

OH, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃ and —

S(═

O)₂—

NH₂;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, benzo[2,1,3]thiadiazolyl, [1,2,3]-benzothiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

SH, —

S—

CH₃, —

S—

C₂Hs, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅) and S(═

O)₂—

NH₂.

39. A compound as claimed in claim 24 wherein

R²¹, R²⁷, R²⁹, R³⁰ and R³¹ each independently denote a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, benzo[2,1,3]thiadiazolyl, [1,2,3]-benzothiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅) and S(═

O)₂—

NH₂.

40. A compound as claimed in claim 24 wherein

n is 1, 2 or 3;

R¹ denotes a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, phenyl and benzyl, wherein the cyclic moiety of the phenyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃ and —

O—

C(CH₃)₃;

R² denotes

—

C(═

S)—

NH—

R³;

—

C(═

O)—

NH—

R⁴;

—

S(═

O)₂—

R⁵;

—

(CH₂)—

C(═

O)—

NH—

R⁶;

—

(CH₂)—

O—

R⁷, —

(CH₂)—

S—

R⁷, —

(CH₂)—

NH—

R⁷, —

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

(CH₂)—

O—

R⁷, —

(CH₂)—

(CH₂)—

S—

R⁷, —

(CH₂)—

NH—

R⁷, —

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

O—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

S—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

NH—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

O—

(CH₂)—

R⁷, —

(CH₂)—

S—

(CH₂)—

R⁷, or —

(CH₂)—

NH—

(CH₂)—

R⁷;

—

C(═

O)—

R⁸, or

—

S(═

O)₂—

NR⁹R¹⁰;

R³ denotes

—

(CHR¹¹)—

C(═

O)—

O—

R¹² or —

(CHR¹¹)—

(CH₂)—

C(═

O)—

O—

R¹²;

—

(CHR¹³)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

R¹⁴, —

(CHR¹³)—

O—

R¹⁴, —

(CHR¹³)—

(CH₂)—

O—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

O—

R¹⁴ or —

(CHR¹³)—

O—

(CH₂)—

R¹⁴;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃ and —

C(═

O)—

C₂F₅;

R⁴ denotes

—

(CHR¹⁵)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

R¹⁶ or —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

R¹⁶;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃ and —

C(═

O)—

C₂F₅;

R⁵ denotes

—

(CHR¹⁷)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

R¹⁸ or —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

R¹⁸;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl and —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃);

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

S(═

O)₂—

CH₃ and —

S(═

O)₂—

C₂H₅;

R⁶ denotes a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CF₃, —

CN, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

S(═

O)₂—

NH-phenyl, phenyl and benzyl, wherein the cyclic moiety of the —

S(═

O)₂—

NH-phenyl, phenyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl and Br;

R⁷ denotes a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,4]-oxadiazolyl, [1,2,3]-thiadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, phenyl and benzyl, wherein the cyclic moiety of the phenyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃ and —

O—

CH₂—

CH₂—

CH₂—

CH₃;

R⁸ denotes

—

(CHR¹⁹)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

O—

(CH₂)—

R²⁰ or —

(CHR¹⁹)—

O—

(CH₂)—

(CH₂)—

O—

R²⁰;

—

(CH═

CH)—

R²¹;

—

(CR²²R²³)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

(CH₂)—

C(═

O)—

O—

R²⁶ or —

(CR²²R²³)—

O—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶;

—

(CHR²⁷)—

O—

C(═

O)—

R²⁸;

—

CH[(CH₂)R²⁹][NH—

S(═

O)₂—

R³⁰];

—

CH[(CH₂)R³¹][NH—

C(═

O)—

O—

R³²];

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl, dithiolanyl, adamantyl and bicyclo[2.2.1]heptyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃ and phenyl;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, benzo[2,1,3]thiadiazolyl, [1,2,3]-benzothiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

S—

CH₃, —

S—

C₂H₅, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

S(═

O)₂—

NH₂, phenyl, —

O-phenyl, —

O-benzyl and benzyl, wherein the cyclic moiety of the phenyl, —

O-phenyl, —

O-benzyl, and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl;

R⁹ and R¹⁰ each independently denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl;

R¹¹, R¹³, R¹⁵, R¹⁷, R¹⁹, R²², R²³, R²⁴, R²⁵ and R²⁶ each independently denote hydrogen or a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R¹², R²⁸ and R³² each independently denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R¹⁴, R¹⁶, R¹⁸ and R²⁰ each independently denote

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, tetrahydrofuranyl, tetrahydrothiophenyl, tetrahydropyranyl and bicyclo[2.2.1]heptyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

(CH₂)—

C(═

O)—

OH and —

C(═

O)—

OH;

or

a group selected from the group consisting of phenyl, and naphthyl, wherein said phenyl or naphthyl group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl and n-heptyl; and

R²¹, R²⁷, R²⁹, R³⁰ and R³¹ each independently denote a group selected from the group consisting of phenyl, naphthyl, indolyl and isoindolyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl and n-heptyl.

41. A compound as claimed in claim 24 wherein

n is 1 or 2;

R¹ denotes a group selected from the group consisting of phenyl and naphthyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, phenyl and benzyl;

R² denotes

—

C(═

S)—

NH—

R³;

—

C(═

O)—

NH—

R⁴;

—

S(═

O)₂—

R⁵;

—

(CH₂)—

C(═

O)—

NH—

R⁶;

—

(CH₂)—

O—

R⁷, —

(CH₂)—

(CH₂)—

O—

R⁷ or —

(CH₂)—

(CH₂)—

(CH₂)—

O—

R⁷;

—

C(═

O)—

R⁸, or

—

S(═

O)₂—

NR⁹R¹⁰;

R³ denotes

—

(CHR¹¹)—

(CH₂)—

C(═

O)—

O—

R¹²;

—

(CHR¹³)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

R¹⁴ or denotes —

(CHR¹³)—

(CH₂)—

O—

R¹⁴;

a group selected from the group consisting of vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl;

or

a phenyl group, wherein said phenyl group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃ and —

C(═

O)—

C₂F₅;

R⁴ denotes

—

(CHR¹⁵)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

R¹⁶ or —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

R¹⁶;

or

a group selected from the group consisting of phenyl and naphthyl, wherein said phenyl or naphthyl group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

NO₂, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃ and —

C(═

O)—

C₂F₅;

R⁵ denotes

—

(CHR¹⁷)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

R¹⁸ or —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

R¹⁸;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl and —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃);

or

a group selected from the group consisting of phenyl, naphthyl, pyrazolyl, thiophenyl, [1,2,3,4]-tetrahydroquinolinyl and [1,2,3,4]-tetrahydroisoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

S(═

O)₂—

CH₃ and —

S(═

O)₂—

C₂H₅;

R⁶ denotes a group selected from the group consisting of phenyl, naphthyl, pyrazolyl, thiophenyl and thiazolyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CF₃, —

CN, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

S(═

O)₂—

NH-phenyl, phenyl and benzyl, wherein the cyclic moiety of the —

S(═

O)₂—

NH-phenyl, phenyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl and Br;

R⁷ denotes a group selected from the group consisting of phenyl, naphthyl, benzo[b]furanyl, benzo[b]thiophenyl and [1,2,4]-oxadiazolyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, phenyl and benzyl, wherein the cyclic moiety of the phenyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃ and —

O—

CH₂—

CH₂—

CH₂—

CH₃;

R⁸ denotes

—

(CHR¹⁹)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

O—

(CH₂)—

R²⁰ or —

(CHR¹⁹)—

O—

(CH₂)—

(CH₂)—

O—

R²⁰;

—

(CH═

CH)—

R²¹;

—

(CR²²R²³)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

(CH₂)—

C(═

O)—

O—

R²⁶ or —

(CR²²R²³)—

O—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶;

—

(CHR²⁷)—

O—

C(═

O)—

R²⁸;

—

CH[(CH₂)R²⁹][NH—

S(═

O)₂—

R³⁰];

—

CH[(CH₂)R³¹][NH—

C(═

O)—

O—

R³²];

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, pyrrolidinyl, piperidinyl and adamantyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃ and phenyl;

or

a group selected from the group consisting of phenyl, naphthyl, 2H-chromenyl, thiophenyl, furanyl, pyrazolyl, triazolyl, pyridinyl, [1,2,3]-thiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, oxazolyl and isoxazolyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

S—

CH₃, —

S—

C₂H₅, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

N—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

S(═

O)₂—

NH₂, phenyl, —

O-phenyl, —

O-benzyl and benzyl;

wherein the cyclic moiety of the phenyl, —

O-phenyl, —

O-benzyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl and Br;

R⁹ and R¹⁰ each independently denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R¹¹, R¹³, R¹⁵, R¹⁷, R¹⁹, R²², R²³, R²⁴, R²⁵ and R²⁶ each independently denote hydrogen or a group selected from the group consisting of methyl, ethyl and n-propyl;

R¹², R²⁸ and R³², mutually independently, in each case denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R¹⁴ denotes

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, tetrahydrofuranyl, tetrahydrothiophenyl and tetrahydropyranyl;

or

a phenyl group which may be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl and Br;

R¹⁶ denotes a group selected from the group consisting of phenyl and naphthyl, wherein the group may in each case be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of F, Cl and Br;

R¹⁸ denotes a 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl group;

R²⁰ denotes

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl;

wherein the group may in each case be substituted with a substituent selected from the group consisting of —

(CH₂)—

C(═

O)—

OH and —

C(═

O)—

OH;

or

a phenyl group which optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃ and —

O—

CH₂—

CH₂—

CH₂—

CH₃;

R²¹ denotes a phenyl group which may be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl, and Br;

R²⁷ denotes a phenyl group;

R²⁹ denotes a phenyl group;

R³⁰ denotes a phenyl group which optionally may be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, and tert-butyl; and

R³¹ denotes an indolyl group.

42. A compound as claimed in claim 24 selected from the group consisting of

[1] 3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid pentafluorophenylamide

[2] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (2,5-dichlorophenyl)amide

[3] 2-oxo-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid benzylamide

[4] 3-(3,5-dimethylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (tetrahydrofuran-2-ylmethyl)amide

[5] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (2-methoxyethyl)amide

[6] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (2-methoxyphenyl)amide

[7] 3-(3,5-dimethylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (3-acetylphenyl)amide

[8] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid o-tolylamide

[9] 3-{[3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioyl]amino}butanoic acid ethyl ester

[10] 3-naphthalen-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid allylamide

[11] 3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid benzylamide

[12] 3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (1-phenylethyl)amide

[13] 3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (4-ethoxyphenyl)amide

[14] 3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (3,5-dichlorophenyl)amide

[15] 3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (3-trifluoromethylphenyl)amide

[16] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid benzylamide

[17] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (tetrahydrofuran-2-ylmethyl)amide

[18] 3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-carbothioic acid phenylamide

[19] 3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid cyclohexylmethylamide

[20] 3-(2-fluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (3-acetylphenyl)amide

[21] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid cyclohexylmethylamide

[22] 3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid 4-chlorobenzylamide

[23] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid benzylamide

[24] 3-(2-fluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-ethoxyphenyl)amide

[25] 3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (2,5-dichlorophenyl)amide

[26] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (2,5-difluorophenyl)amide

[27] 3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methyl-3-nitrophenyl)amide

[28] 3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid 4-fluorobenzylamide

[29] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (2,5-difluorophenyl)amide

[30] 4-[(3-naphthalen-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl)amino]benzoic acid ethyl ester

[31] 2-oxo-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-chloro-3-trifluoromethylphenyl)amide

[32] 3-(2-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (2,5-difluorophenyl)amide

[33] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-cyanophenyl)amide

[34] 3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methyl-3-nitrophenyl)amide

[35] 3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-methoxyphenyl)amide

[36] 3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid 3,4-dichlorobenzylamide

[37] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-chloro-3-trifluoromethylphenyl)amide

[38] 2-oxo-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-cyanophenyl)amide

[39] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methoxyphenyl)amide

[40] 2-oxo-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methyl-3-nitrophenyl)amide

[41] 3-(4-iodobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-butoxyphenyl)amide

[42] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid 3,4-dichlorobenzylamide

[43] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (1-phenylethyl)amide

[44] 3-naphthalen-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid 3,4-dichlorobenzylamide

[45] 3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid phenethylamide

[46] 2-oxo-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-methoxyphenyl)amide

[47] 3-(4-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methoxyphenyl)amide

[48] 2-oxo-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (1-naphthalen-1-yl-ethyl)amide

[49] 2-oxo-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid phenethylamide

[50] 3-(4-iodobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methyl-3-nitrophenyl)amide

[51] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-cyanophenyl)amide

[52] 3-naphthalen-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methoxyphenyl)amide

[53] 3-{[3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]amino}benzoic acid ethyl ester

[54] 2-oxo-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (1-naphthalen-1-yl-ethyl)amide

[55] 3-naphthalen-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (2,5-dimethoxyphenyl)amide

[56] 3-(4-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-acetylphenyl)amide

[57] 3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid phenethylamide

[58] 3-(4-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (5-chloro-2-methoxyphenyl)amide

[59] 3-{[2-oxo-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]amino}benzoic acid ethyl ester

[60] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-fluorophenyl)amide

[61] 3-{[3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]amino}benzoic acid ethyl ester

[62] 3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-methoxyphenyl)amide

[63] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (1-naphthalen-1-yl-ethyl)amide

[64] {2-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-2-oxoethoxy}acetic acid

[65] 4-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-3,3-dimethyl-4-oxobutanoic acid

[66] [2-[3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]carbamic acid tert-butyl ester

[67] 5-[3-(2-fluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-3-methyl-5-oxopentanoic acid

[68] 3,3-dimethyl-5-[3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid

[69] 5-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-3-methyl-5-oxopentanoic acid

[70] {2-oxo-2-[2-oxo-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]ethoxy}acetic acid

[71] (1-{2-[3-(2-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-2-oxoethyl}cyclopentyl)acetic acid

[72] (1-{2-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-2-oxoethyl}cyclopentyl)acetic acid

[73] 5-(3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl)-3-methyl-5-oxopentanoic acid

[75] N-[4-(3,5-dichlorophenylsulfamoyl)phenyl]-2-[3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]acetamide

[76] N-(2,5-dimethyl-2H-pyrazol-3-yl)-2-[3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]acetamide

[80] N-(3-cyano-4-methylthiophen-2-yl)-2-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]acetamide

[85] 2-[2-oxo-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-N-(4-phenyl-5-trifluoromethylthiophen-3-yl)acetamide

[86] 2-[3-(2-fluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-N-(4-phenyl-thiazolyl-2-yl)acetamide

[87] 2-[2-oxo-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-N-(4-trifluoromethoxyphenyl)acetamide

[91] N-{4-[3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]phenyl}acetamide

[92] 8-(4-ethoxybenzoyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[93] 3-[3-(4-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-3-oxopropionic acid methyl ester

[94] 2-[8-(2,4-difluorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[95] 8-(3-dimethylaminobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[96] N-{4-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]phenyl}acetamide

[97] 8-(4-bromobenzoyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[98] 4-[8-(adamantane-1-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[99] 3-(3,5-dimethylbenzyl)-8-(2-ethylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[100] 3-(3-bromobenzyl)-8-(4-chlorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[101] 8-[3-(2-chlorophenyl)-5-methylisoxazole-4-carbonyl]-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[102] 3-(3-bromobenzyl)-8-(4-ethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[103] 8-(4-butoxybenzylsulfonyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[104] 8-(biphenyl-4-carbonyl)-3-(3-bromobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[105] acetic acid 2-[3-(3,5-dimethylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-2-oxo-1-phenylethyl ester

[106] 4-[2-oxo-8-(2-phenylcyclopropanecarbonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[107] 8-(2,5-dimethoxybenzylsulfonyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[108] 8-(2-chlorobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[109] 3-(3-bromobenzyl)-8-(4-nitrobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[110] N-{1-benzyl-2-[3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-2-oxoethyl}-4-methylbenzylsulfonamide

[111] 8-(2-ethylsulfanylpyridine-3-carbonyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[112] 8-(2,4-dimethoxybenzoyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[113] 3-(3,5-dimethylbenzyl)-8-[2-(3-methoxyphenyl)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[114] 3-(3,5-dimethylbenzyl)-8-(4-methoxy-2,3,6-trimethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[115] 4-[8-(biphenyl-4-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[116] 8-(2-chlorobenzylsulfonyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[117] 8-(benzo[1,2,5]oxadiazole-5-carbonyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[118] 8-(biphenyl-4-carbonyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[119] 3-(3,5-dimethylbenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[120] 8-(6-chloropyridine-3-carbonyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[121] 3-(3-bromobenzyl)-8-(2-ethylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[122] 3-(3,5-dimethylbenzyl)-8-(5-methylisoxazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[123] 3-(2-methoxy-5-nitrobenzyl)-8-pentanoyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[124] 8-(4-bromobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[125] 8-(5-tert-butyl-2-methylfuran-3-carbonyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[126] 8-(3-chlorobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[127] 8-(2-ethylsulfanylpyridine-3-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[128] 3-(3,5-dimethylbenzyl)-8-(isoxazole-5-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[129] 3-(3-bromobenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[130] 3-(3,5-dimethylbenzyl)-8-(thiophene-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[131] 8-(3-chloro-4-fluorobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[132] 8-(2,6-difluoro-3-methylbenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[133] 4-[3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-4-oxobutanoic acid methyl ester

[134] 3-[8-(2-ethylbutyryl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[135] 3-[8-(3-bromobenzylsulfonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[136] 3-(3,4-difluorobenzyl)-8-(4-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[137] 3-(3-bromobenzyl)-8-(3,5-dimethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[138] 8-(3-dimethylaminobenzoyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[139] 8-(2,6-dichlorobenzoyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[140] 3-(2-methoxy-5-nitrobenzyl)-8-(2-phenoxypyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[141] 8-[2-(3-methoxyphenyl)acetyl]-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[142] 4-{2-oxo-8-[2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl]-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl}benzonitrile

[143] 8-(3,5-bis-trifluoromethylbenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[144] 3-(3-bromobenzyl)-8-(2-phenoxypyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[145] 3-(2-methoxy-5-nitrobenzyl)-8-[2-(3-methoxyphenyl)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[146] 3-(3,4-difluorobenzyl)-8-(2-phenoxypyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[147] 3-[8-(4-bromo-3-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[148] 3-(3-bromobenzyl)-8-(4-propylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[149] 3-biphenyl-2-ylmethyl-8-(3-chlorobenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[150] 8-[2-(3,4-dimethoxyphenyl)acetyl]-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[151] 2-[8-(2-chloro-4-nitrobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[152] 3-[2-oxo-8-(2,4,6-trimethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[153] 3-benzyl-8-(4-fluorobenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[154] 3-(4-fluorobenzyl)-8-(toluene-4-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[155] 4-[2-oxo-8-(toluene-4-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[156] 3-(2-fluorobenzyl)-8-(toluene-4-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[157] 3-(3,4-difluorobenzyl)-8-(toluene-4-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[158] 3-(4-tert-butylbenzyl)-8-(toluene-4-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[159] 8-(toluene-4-sulfonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[160] 2-[3-(4-fluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-sulfonyl]benzoic acid methyl ester

[161] 2-[3-(3-methoxybenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-sulfonyl]benzoic acid methyl ester

[162] 2-[3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-sulfonyl]benzoic acid methyl ester

[163] 3-benzyl-8-(2-methanesulfonylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[164] 8-(2-methanesulfonylbenzylsulfonyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[165] 3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-sulfonic acid dimethylamide

[166] 4-[8-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[167] 3-(4-fluorobenzyl)-8-(4-methoxybenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[168] 3-(4-methylbenzyl)-8-(4-trifluoromethoxybenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[169] 8-(4-trifluoromethoxybenzylsulfonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[170] 8-(propane-1-sulfonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[171] 3-(2-methoxy-5-nitrobenzyl)-8-(4-propylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[172] 3-biphenyl-2-ylmethyl-8-(4-propylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[173] 8-(3-bromobenzylsulfonyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[174] 8-(3-bromobenzylsulfonyl)-3-(3-bromobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[175] 2-{8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl}benzonitrile

[176] 3-benzyl-8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[177] 8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[178] 8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[179] 8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[180] 3-biphenyl-2-ylmethyl-8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[181] 8-(4,5-dichlorothiophene-2-sulfonyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[182] 8-(4,5-dichlorothiophene-2-sulfonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[183] 3-(3-bromobenzyl)-8-(4,5-dichlorothiophene-2-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[184] 2-[8-(4-methoxy-2,3,6-trimethylbenzylsulfonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[185] 3-(2-fluorobenzyl)-8-(4-methoxy-2,3,6-trimethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[186] 3-(4-tert-butylbenzyl)-8-[2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[187] 8-(butane-1-sulfonyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[188] 3-(4-methylbenzyl)-8-(thiophene-2-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[189] 8-(4-chloro-2,5-dimethylbenzylsulfonyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[190] 3-benzyl-8-(4-chloro-2,5-dimethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[191] 8-(4-chloro-2,5-dimethylbenzylsulfonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[192] 3-biphenyl-2-ylmethyl-8-(4-chloro-2,5-dimethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[193] 8-(4-chloro-2,5-dimethylbenzylsulfonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[194] 3-(4-fluorobenzyl)-8-(2-trifluoromethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[195] 3-(3-methoxybenzyl)-8-(2-trifluoromethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[196] 3-benzyl-8-(2-methyl-5-nitrobenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[197] 3-(4-tert-butylbenzyl)-8-(2-methyl-5-nitrobenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[198] 3-(4-tert-butylbenzyl)-8-(toluene-3-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[199] 8-(furan-2-carbonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[200] 3-(3-bromobenzyl)-8-(furan-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[201] 4-[8-(naphthalene-1-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[202] 3-(3,4-difluorobenzyl)-8-(naphthalene-1-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[203] 3-(3-bromobenzyl)-8-(naphthalene-1-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[204] 2-[8-(3-nitrobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[205] 4-[8-(3-nitrobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[206] 3-(3-bromobenzyl)-8-(3,5-difluorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[207] 8-(2-benzyloxy-acetyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[208] 8-(2-chlorobenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[209] 8-(2-chlorobenzoyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[210] 8-(2-chlorobenzoyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[211] 3-biphenyl-2-ylmethyl-8-(2-chlorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[212] 8-(2,6-dichlorobenzoyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[213] 3-(4-tert-butylbenzyl)-8-(2,6-dichlorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[214] 3-(3-bromobenzyl)-8-(2,6-dichlorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[215] 8-(2,6-dichlorobenzoyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[216] 2-[8-(2-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[217] 8-(2-methylbenzoyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[218] 8-(2-methylbenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[219] 3-(2-methoxy-5-nitrobenzyl)-8-(2-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[220] 3-(3,4-difluorobenzyl)-8-(2-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[221] 8-(2-methylbenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[222] 8-(2-methylbenzoyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[223] 8-(3-bromobenzoyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[224] 8-(3-bromobenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[225] 8-(3-bromobenzoyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[226] 8-(3-bromobenzoyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[227] 8-(3-bromobenzoyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[228] 8-(3-bromobenzoyl)-3-(4-tert-butylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[229] 3-benzyl-8-(3-fluorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[230] 8-(3-fluorobenzoyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[231] 3-(3,4-difluorobenzyl)-8-(3-fluorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[232] 8-(3-fluorobenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[233] 3-(3-bromobenzyl)-8-(3-fluorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[234] 8-(3-chlorobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[235] 3-benzyl-8-(3-chlorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[236] 4-[8-(3,4-dichlorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[237] 3-(4-iodobenzyl)-8-(3-methoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[238] 3-(2-fluorobenzyl)-8-(3-methoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[239] 3-(4-tert-butylbenzyl)-8-(3-methoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[240] 3-benzyl-8-(3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[241] 3-(2-methoxy-5-nitrobenzyl)-8-(3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[242] 3-(4-tert-butylbenzyl)-8-(3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[243] 8-(3-methylbenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[244] 3-(3,4-difluorobenzyl)-8-(2-phenyl-butyryl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[245] 3-benzyl-8-[3-(2-chlorophenyl)-5-methylisoxazole-4-carbonyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[246] 4-[8-(2,3-dichlorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[247] 8-[2-(4-chlorophenyl)acetyl]-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[248] 3-biphenyl-2-ylmethyl-8-[2-(4-chlorophenyl)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[249] 8-[2-(4-chlorophenyl)acetyl]-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[250] 3-(4-tert-butylbenzyl)-8-[3-(2-chlorophenyl)acryloyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[251] 3-biphenyl-2-ylmethyl-8-[3-(2-chlorophenyl)acryloyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[252] 3-(3-bromobenzyl)-8-[3-(2-chlorophenyl)acryloyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[253] 4-[8-(2,3-difluorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[254] 8-(2,3-difluorobenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[255] 8-(2,3-difluorobenzoyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[256] 2-[2-oxo-8-(2-propylpentanoyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[257] 3-(3,4-difluorobenzyl)-8-(2-propylpentanoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[258] 8-(2-chloro-4-nitrobenzoyl)-3I-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[259] 8-(2-chloro-4-nitrobenzoyl)-3I-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[260] 3-(4-tert-butylbenzyl)-8-(2-chloro-4-nitrobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[261] 8-(2-chloro-4-nitrobenzoyl)-3I-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[262] 3-biphenyl-2-ylmethyl-8-(2-chloro-4-nitrobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[263] 3-(3-bromobenzyl)-8-(2-chloro-4-nitrobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[264] 8-(2-chloro-4-nitrobenzoyl)-3I-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[265] 8-(2-chloropyridine-3-carbonyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[266] 2-[8-(2-chloropyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[267] 8-(2-chloropyridine-3-carbonyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[268] 8-(2-chloropyridine-3-carbonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[269] 3-(3-methoxybenzyl)-8-(2-methylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[270] 3-(4-methylbenzyl)-8-(2-methylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[271] 3-(4-iodobenzyl)-8-(2-methylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[272] 3-(3,4-difluorobenzyl)-8-(2-methylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[273] 3-(4-tert-butylbenzyl)-8-(2-methylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[274] 8-(2-methylsulfanylpyridine-3-carbonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[275] 8-(2-ethylsulfanylpyridine-3-carbonyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[276] 3-[8-(2-ethylsulfanylpyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[277] 2-[8-(2-ethylsulfanylpyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[278] 8-(2-ethylsulfanylpyridine-3-carbonyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[279] 3-benzyl-8-(2-ethylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[280] 8-(2-ethylsulfanylpyridine-3-carbonyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[281] 4-[8-(6-chloropyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[282] 8-(6-chloropyridine-3-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[283] 8-(6-chloropyridine-3-carbonyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[284] 3-(4-tert-butylbenzyl)-8-(6-chloropyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[285] 3-biphenyl-2-ylmethyl-8-(6-chloropyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[286] 3-(3-methoxybenzyl)-8-(4-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[287] 3-(3,4-difluorobenzyl)-8-(4-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[288] 8-[3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl]-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[289] 8-[3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl]-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[290] 8-[3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl]-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[291] 8-[3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl]-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[292] 3-(4-methylbenzyl)-8-(3-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[293] 3-(4-iodobenzyl)-8-(3-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[294] 3-(3,4-difluorobenzyl)-8-(3-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[295] 3-naphthalen-2-ylmethyl-8-(3-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[296] 4-[8-(isoxazole-5-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[297] 8-(isoxazole-5-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[298] 8-(isoxazole-5-carbonyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[299] 3-(3-bromobenzyl)-8-(isoxazole-5-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[300] 2-[8-(2-chloro-6-fluorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[301] 4-[8-(2-chloro-6-fluorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[302] 8-(2-chloro-6-fluorobenzoyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[303] 3-biphenyl-2-ylmethyl-8-(2-chloro-6-fluorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[304] 8-(2,5-dimethylfuran-3-carbonyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[305] 4-[8-(2,5-dimethylfuran-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[306] 4-[8-(4-bromo-3-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[307] 8-(4-bromo-3-methylbenzoyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[308] 3-benzyl-8-(4-bromo-3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[309] 8-(4-bromo-3-methylbenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[310] 8-(4-bromo-3-methylbenzoyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[311] 8-(4-bromo-3-methylbenzoyl)-3-(4-tert-butylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[312] 3-biphenyl-2-ylmethyl-8-(4-bromo-3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[313] 8-(4-bromo-3-methylbenzoyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[314] 8-(2,6-difluoro-3-methylbenzoyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[315] 2-[8-(2,6-difluoro-3-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[316] 4-[8-(2,6-difluoro-3-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[317] 8-(2,6-difluoro-3-methylbenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[318] 8-(2,6-difluoro-3-methylbenzoyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[319] 8-(2-chloro-6-fluoro-3-methylbenzoyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[320] 8-(2-chloro-6-fluoro-3-methylbenzoyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[321] 8-(2-chloro-6-fluoro-3-methylbenzoyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[322] 3-biphenyl-2-ylmethyl-8-(6-chloro-2-fluoro-3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[323] 3-benzyl-8-(3-difluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[324] 8-(3-difluoromethylsulfanylbenzoyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[325] 8-(3-difluoromethylsulfanylbenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[326] 3-(3-bromobenzyl)-8-(3-difluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[327] 3-[8-(3-chloro-2-fluorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[328] 8-(3-chloro-2-fluorobenzoyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[329] 8-(3-chloro-2-fluorobenzoyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[330] 3-(3-methoxybenzyl)-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[331] 2-[2-oxo-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[332] 4-[2-oxo-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[333] 3-(4-iodobenzyl)-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[334] 3-naphthalen-2-ylmethyl-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[335] 3-(4-trifluoromethylbenzyl)-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[336] 8-(2-chloro-5-trifluoromethylbenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[337] 8-(2-chloro-5-trifluoromethylbenzoyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[338] 8-(2-chloro-5-trifluoromethylbenzoyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[339] 8-(2,3-difluoro-4-methylbenzoyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[340] 4-[8-(2,3-difluoro-4-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[341] 3-benzyl-8-(2,3-difluoro-4-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[342] 8-(2,3-difluoro-4-methylbenzoyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[343] 3-(3,4-difluorobenzyl)-8-(2,3-difluoro-4-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[344] 8-(2,3-difluoro-4-methylbenzoyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[345] 3-biphenyl-2-ylmethyl-8-(2,3-difluoro-4-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[346] 3-(3-bromobenzyl)-8-(2,3-difluoro-4-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[347] 3-benzyl-8-[2-(2-methoxyethoxy)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[348] 3-(2-fluorobenzyl)-8-[2-(2-methoxyethoxy)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[349] 3-(3,4-difluorobenzyl)-8-[2-(2-methoxyethoxy)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[350] 3-(4-tert-butylbenzyl)-8-[2-(2-methoxyethoxy)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[351] 8-[2-(2-methoxyethoxy)acetyl]-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[352] 8-(1-acetylpiperidine-4-carbonyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[353] 4-{8-[2-(3-chlorophenoxy)acetyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl}benzonitrile

[354] 8-[2-(3-chlorophenoxy)acetyl]-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[355] 3-(3-bromobenzyl)-8-[2-(3-chlorophenoxy)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[356] 8-[2-(3-chlorophenoxy)acetyl]-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[357] 4-[3-(3-methoxybenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]benzylsulfonamide

[358] N-{4-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]phenyl}acetamide

[359] 8-(3-dimethylaminobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[360] 3-(4-tert-butylbenzyl)-8-(3-dimethylaminobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[361] 3-(3-bromobenzyl)-8-(3-dimethylaminobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[362] 3-(4-methylbenzyl)-8-(4-phenoxybutyryl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[363] 8-(4-phenoxybutyryl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[364] 3-(2-fluorobenzyl)-8-(4-phenoxybutyryl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[365] 8-(2,3-dimethylbenzoyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[366] 3-[8-(2,3-dimethylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[367] 8-(2,3-dimethylbenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[368] 8-(2,3-dimethylbenzoyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[369] 8-(2,3-dimethylbenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[370] 8-(2,3-dimethylbenzoyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[371] 8-(2,3-dimethylbenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[372] 3-biphenyl-2-ylmethyl-8-(2,3-dimethylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[373] 4-[8-(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[374] 3-benzyl-8-(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[375] 3-(3,4-difluorobenzyl)-8-(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[376] 8-(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbonyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[377] 3-biphenyl-2-ylmethyl-8-(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[378] 3-(4-tert-butylbenzyl)-8-[3-(2,6-dichlorophenyl)-5-methylisoxazole-4-carbonyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[379] 3-[2-oxo-8-(2-phenoxypyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[380] 2-[2-oxo-8-(2-phenoxypyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[381] 3-(4-fluorobenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[382] 3-(3-methoxybenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[383] 3-(3,5-dimethylbenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[384] 2-[2-oxo-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[385] 3-(2-fluorobenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[386] 3-(3,4-difluorobenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[387] 3-biphenyl-2-ylmethyl-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[388] 4-[8-(3-chlorothiophene-2-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[389] 8-(3-chlorothiophene-2-carbonyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[390] 3-biphenyl-2-ylmethyl-8-(3-chlorothiophene-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[391] 8-[1-(4-chlorophenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl]-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[392] 8-[1-(4-chlorophenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl]-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[393] 8-[1-(4-chlorophenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl]-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[394] 3-(4-tert-butylbenzyl)-8-(5-tert-butyl-2-methyl-2H-pyrazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[395] 3-[8-(5-methylisoxazole-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[396] 3-(3,5-dimethylbenzyl)-8-(5-methylisoxazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[397] 2-[8-(5-methylisoxazole-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[398] 4-[8-(5-methylisoxazole-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[399] 3-benzyl-8-(5-methylisoxazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[400] 3-(3,4-difluorobenzyl)-8-(5-methylisoxazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[401] 3-biphenyl-2-ylmethyl-8-(5-methylisoxazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[402] 8-(4-methyl[1,2,3]thiadiazole-5-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[403] 3-(4-tert-butylbenzyl)-8-(4-methyl[1,2,3]thiadiazole-5-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[404] 8-(4-methyl[1,2,3]thiadiazole-5-carbonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[405] 4-[2-oxo-8-(1-phenyl-5-propyl-1H-pyrazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[406] 3-(3,4-difluorobenzyl)-8-(1-phenyl-5-propyl-1H-pyrazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[407] 3-naphthalen-2-ylmethyl-8-(1-phenyl-5-propyl-1H-pyrazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[408] 8-(1-phenyl-5-propyl-1H-pyrazole-4-carbonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[409] 3-[8-(2-chloropyridine-4-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[410] 8-(2-chloropyridine-4-carbonyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[411] 8-(5-tert-butyl-2-methylfuran-3-carbonyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[412] 3-[8-(5-tert-butyl-2-methylfuran-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[413] 2-[8-(5-tert-butyl-2-methylfuran-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[414] 4-[8-(5-tert-butyl-2-methylfuran-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[415] 8-(5-tert-butyl-2-methylfuran-3-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[416] 8-(5-tert-butyl-2-methylfuran-3-carbonyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[417] 3-biphenyl-2-ylmethyl-8-(5-tert-butyl-2-methylfuran-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[418] 3-(3-bromobenzyl)-8-(5-tert-butyl-2-methylfuran-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[419] 8-(benzo[1,2,5]oxadiazole-5-carbonyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[420] 8-(benzo[1,2,5]oxadiazole-5-carbonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[421] 3-[8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[422] 2-[8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[423] 4-[8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[424] 8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[425] 3-(3,4-difluorobenzyl)-8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[426] 3-(3-bromobenzyl)-8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[427] 8-(6-chloro-2H-chromene-3-carbonyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[428] 8-(2-chloropyridine-4-carbonyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[429] 8-(2-chloropyridine-4-carbonyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[430] 8-acetyl-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[431] 8-acetyl-3-(3-bromobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one and

[432] 3-(2-methoxy-5-nitrobenzyl)-8-(3-phenoxypropyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one;

and pharmaceutically acceptable salts thereof.

43. A pharmaceutical composition comprising a compound as claimed in claim 24 and at least one physiologically acceptable auxiliary substance.

44. A method for producing a substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one compound corresponding to formula I according to claim 24 comprising:

reacting a compound corresponding to formula II

wherein PG denotes a protective group,

in a reaction medium in the presence of a base,

with at least one compound corresponding to the formula

R¹—

(CH₂)_n—

X

wherein

R¹ and n have the meanings given in claim 24, and

X denotes a leaving group,

to yield a compound corresponding to formula III

wherein R¹, PG and n have the meanings given above, and

reacting the compound of formula III in a reaction medium to eliminate the protective group,

to yield a compound corresponding to formula IV,

wherein R¹ and n have the meanings given above; and

reacting a compound corresponding to formula IV in a reaction medium

with an isothiocyanate corresponding to the formula

R³—

N═

C═

S

wherein R³ has the meaning given in claim 24,

to yield at least one compound of formula I, wherein

R¹ and n have the meanings given above, and

R² denotes —

C(═

S)—

NH—

R³, wherein R³ has the meaning given above;

or

reacting a compound of formula IV in a reaction medium

with an isocyanate corresponding to the formula

R⁴—

N═

C═

O

wherein R⁴ has the meaning given in claim 24,

to yield a compound of formula I, wherein

R¹ and n have the meanings given above, and

R² denotes —

C(═

O)—

NH—

R⁴, wherein R⁴ has the meaning given above, or

reacting a compound of formula IV in a reaction medium,

with at least one sulfonic acid derivative corresponding to the formula

R⁵—

S(═

O)₂—

X

wherein R⁵ has the meaning given in claim 24, and

X denotes a leaving group

to yield a compound of formula I, wherein

R¹ and n have the meanings given above and

R² denotes —

S(═

O)₂—

R⁵, wherein R⁵ has the meaning given above, or

reacting a compound of formula IV in a reaction medium,

with a compound corresponding to the formula

X—

(CH₂)—

C(═

O)—

NHR⁶

wherein R⁶ has the meaning given in claim 24, and X denotes a leaving group,

to yield a compound of formula I, wherein R¹ and n have the meanings given above and R² denotes —

(CH₂)—

C(═

O)—

NH—

R⁶, wherein R⁶ has the meaning given above or

reacting a compound of formula IV in a reaction medium,

with a compound corresponding to the formula

X—

(CH₂)-D_aa-(CH₂)_bb-E_cc-(CH₂)_dd—

R⁷

wherein R⁷, D, E, aa, bb, cc and dd have the meanings given in claim 24, and

X denotes a leaving group,

to yield a compound of formula I, wherein R¹ and n have the meanings given above, and R² denotes —

(CH₂)-D_aa-(CH₂)_bb-E_cc-(CH₂)_dd—

R⁷, wherein R⁷, D, E, aa, bb, cc and dd have the meanings given above;

or

reacting a compound of formula IV in a reaction medium,

with a carboxylic acid derivative corresponding to the formula

R⁸—

C(═

O)—

X

wherein R⁸ has the meaning given in claim 24, and X denotes a leaving group,

to yield a compound of formula I, wherein R¹ and n have the meanings given above and R² denotes —

C(═

O)—

R⁸, wherein R⁸ has the meaning given above;

or

reacting a compound of formula IV in the presence of a coupling reagent in a reaction medium,

with a carboxylic acid corresponding to the formula

R⁸—

C(═

O)—

OH

wherein R⁸ has the meaning given in claim 24,

to yield a compound of formula I, wherein R¹ and n have the meanings given above, and R² denotes —

C(═

O)—

R⁸, wherein R⁸ has the meaning given above;

or

reacting a compound of formula IV in a reaction medium,

with a sulfonic acid derivative corresponding to the formula

X—

S(═

O)₂—

NR⁹R¹⁰

wherein R⁹ and R¹⁰ have the meanings given in claim 24, and X denotes a leaving group,

to yield a compound of formula I, wherein R¹ and n have the meanings given above, and R² denotes —

S(═

O)₂—

NR⁹R¹⁰, wherein R⁹ and R¹⁰ have the meanings given above;

and optionally purifying or isolating the produced compound of formula I.

45. A method as claimed in claim 44 wherein:

PG denotes a tert-butyloxycarbonyl or benzyloxycarbonyl protective group;

a compound of formula II is reacted in the presence of a metal hydride base selected from the group consisting of potassium hydride and sodium hydride;

X denotes a halogen leaving group selected from the group consisting of chlorine and bromine;

the elimination of the protective group is effected in the presence of an acid or in the presence of a base or in the presence of hydrogen and a palladium on carbon catalyst;

the compound of formula IV is obtained in the form of a hydrochloride salt,

the compound of formula IV is reacted with the isothiocyanate of formula R³—

N═

C═

S or with the isocyanate of formula R⁴—

N═

C═

O or with the sulfonic acid derivative of formula R⁵—

S(═

O)₂—

X or with the compound of formula X—

(CH₂)—

C(═

O)—

NHR⁶ or with the compound of formula X—

(CH₂)-D_aa-(CH₂)_bb-E_cc-(CH₂)_dd—

R⁷ or with the carboxylic acid derivative of formula R⁸—

C(═

O)—

X or with the carboxylic acid of formula R⁸—

C(═

O)—

OH or with the sulfonic acid derivative of formula X—

S(═

O)₂—

NR⁹R¹⁰ in the presence of a base selected from the group consisting of triethylamine, (4,4)-dimethylaminopyridine, pyridine, diisopropylethylamine and N-methylmorpholine,

46. A method of treating or inhibiting pain in a subject in need thereof, said method comprising administering to said subject a pharmacologically effective amount of a compound as claimed in claim 24

47. A method as claimed in claim 24 wherein said pain is selected from the group consisting of acute pain, chronic pain, visceral pain and neuropathic pain.

48. A method of treating or inhibiting a disorder or disease state selected from the group consisting of eating disorders selected from the group consisting of bulimia, anorexia, obesity and cachexia;

water retention conditions;

migraine;

chronic paroxysmal hemicrania;

depression;

urinary incontinence;

coughing;

asthma;

glaucoma;

tinnitus;

inflammation;

neurodegenerative diseases selected from the group consisting of Parkinson'"'"'s disease, Huntington'"'"'s chorea, Alzheimer'"'"'s disease and multiple sclerosis;

cognitive dysfunction;

memory disorders;

cognitive deficiency states;

attention deficit syndrome;

epilepsy;

catalepsy;

narcolepsy;

diarrhoea;

gastritis;

stomach ulcer;

pruritus;

anxiety states;

panic attacks;

schizophrenia;

cerebral ischaemic episodes;

muscle spasms;

cramps;

gastro-oesophageal reflux syndrome;

alcohol and/or drug abuse or dependency, withdrawal symptoms associated with alcohol and/or drug dependency;

development of tolerance to opioids;

or for regulating food intake;

modulating locomotor activity, suppressing the urinary reflex;

regulating the cardiovascular system, effecting local anaesthesia;

increasing vigilance;

increasing libido;

effecting diuresis, or for antinatriuresis in a subject in need thereof, said method comprising administering to said subject a pharmacologically effective amount of a compound as claimed in claim 24