Infusion sets for the delivery of a therapeutic substance to a patient

• US 20090105658A1
• Filed: 12/28/2005
• Published: 04/23/2009
• Est. Priority Date: 12/28/2005
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Jennewine, R. Curtis
• Granted Patent: US 8,353,881 B2
• Time in Patent Office: Days
• US Class Current: 604/175
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150503 Single-ended needles hollow piercing element tip design A61B5/150396, needle sets for catheters A61M25/06, needles for bringing media into the body A61M5/32
• CPC Class Codes: A61B 5/15087 short range, e.g. between console and disposable using implanted devices A61B5/150877
• CPC Class Codes: A61B 5/150969 Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
• CPC Class Codes: A61B 5/15105 Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices
• CPC Class Codes: A61B 5/15142 Devices intended for single use, i.e. disposable
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2005/3201 Coaxially assembled needle cannulas placed on top of another, e.g. needles having different diameters
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2205/0205 : Materials having antiseptic or antimicrobial properties, e.g. silver compounds, rubber with sterilising agent
• CPC Class Codes: A61M 2205/3523 : using telemetric means
• CPC Class Codes: A61M 2205/3569 : sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2209/088 : on the body
• CPC Class Codes: A61M 2230/005 : Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/201 : Glucose concentration
• CPC Class Codes: A61M 37/00 : Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 5/142 : Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/14244 : adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/158 : Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: B05D 5/00 : Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures

Abstract

Devices and methods for delivering a therapeutic substance to a patient are provided. Embodiments include infusion sets that include an active agent. Also provided are systems and kits.

Claims

1. An infusion set for delivering insulin to a patient, the infusion set comprising an antimicrobial agent or anti-scarring agent or an antimicrobial agent and an anti-scarring agent, wherein the infusion set includes a first cannula and a second cannula, said first cannula including a first portion substantially disposed within the second cannula.

2. The infusion set of claim 1, wherein the infusion set includes tubing and the tubing comprises the antimicrobial agent or anti-scarring agent or antimicrobial agent and anti-scarring agent.

3. The infusion set of claim 1, wherein the first cannula, or the second cannula, or first and second cannulas comprises the antimicrobial agent or anti-scarring agent or antimicrobial agent and anti-scarring agent.

4. The infusion set of claim 1, wherein the infusion set includes an insertion element for inserting the first and second cannulas into a patient and the insertion element comprises the antimicrobial agent or anti-scarring agent or antimicrobial agent and anti-scarring agent.

5. The infusion set of claim 1, wherein the infusion set includes a securement element for securing the infusion set to the patient and the securement element comprises the antimicrobial agent or anti-scarring agent or antimicrobial agent and anti-scarring agent.

6. The infusion set of claim 1, wherein the antimicrobial agent or anti-scarring agent or antimicrobial agent and an anti-scarring agent is a coating.

7. The infusion set of claim 1, wherein the antimicrobial agent or anti-scarring agent or antimicrobial agent and an anti-scarring agent is integrated into the material of the infusion set.

8. The infusion set of claim 1, further comprising a housing for containing insulin, and which is connectable to the infusion set.

9. The infusion set of claim 1, wherein the infusion set comprises an antimicrobial agent.

10. The infusion set of claim 9, wherein the antimicrobial agent comprises at least one of penicillin, mupirocin, erthromycin, polymyxin, silver sulfadiazine, cephalosporins, bacitracin, tetracycline, doxycycline, gentamycin, quinolines, neomycin, clindamycin, kanamycin, metronidazole, iodine, Povidine-iodine, benzalkonium chloride, benzoic acid, chlorhexidine, nitrofurazone, benzoyl peroxide, hydrogen peroxide, hexachlorophene, phenol, resorcinol, and cetylpyridinium chloride, nystatin, ciclopirox, chloroxylenol, triacetin, sulconazole, undecylenic acid, tolnaftate, miconizole, clotrimazole, oxiconazole, griseofulvin, econazole, ketoconozole, and amphotericin B, acyclovir, ribarivin, interferons, nitrofurazone, iodine, silver nitrate, silver sulfadiazine, zinc oxide, or combinations thereof.

11. The infusion set of claim 1, wherein the infusion set includes an anti-scarring agent.

12. A system for delivering insulin to a patient, the system comprising:

an insulin delivery device comprising an infusion set according to claim 1; and

a glucose sensor.

13. The system of claim 12, wherein at least a portion of the glucose sensor is adapted to be positioned below the skin of the patient.

14. The system of claim 12, wherein the system is adapted so that glucose information from the sensor is communicated to the insulin delivery device.

15. The system of claim 12, wherein the system is adapted so that the glucose information is automatically communicated to the insulin delivery device.

16. The system of claim 12, wherein the insulin delivery device is adapted to determine an amount of insulin to be delivered based on glucose information from the sensor.

17. The system of claim 12, wherein the antimicrobial agent or anti-scarring agent or antimicrobial agent and an anti-scarring agent is a coating.

18. The system of claim 12, wherein the antimicrobial agent or anti-scarring agent or antimicrobial agent and an anti-scarring agent is integrated into the material of the infusion set.

19. The system of claim 12, further comprising a securement element for securing the infusion set to the patient and the securement element comprises an antimicrobial agent or anti-scarring agent or antimicrobial agent and anti-scarring agent.

21. The infusion set of claim 1 wherein the first cannula and the second cannula are simultaneously inserted through a skin layer of the patient.

22. The infusion set of claim 1 wherein the first cannula and the second cannula are positioned at a respective first location and a second location under the skin layer.

23. The infusion set of claim 22 wherein the first location of the first cannula and the second location of the second cannula are different.

24. The infusion set of claim 1 wherein the first cannula and the second cannula are withdrawn from the patient at a respective different times.

20. An infusion set for delivering insulin to a patient, the infusion set comprising a needle having provided thereon an antimicrobial agent or anti-scarring agent or an antimicrobial agent and an anti-scarring agent.