System and method for identification of individual samples from a multiplex mixture
First Claim
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1. An identifier element for identifying an origin of a template nucleic acid molecule, comprising:
- a nucleic acid element comprising a sequence composition that enables detection of an introduced error in sequence data generated from the nucleic acid element and correction of the introduced error, wherein the nucleic acid element is constructed to couple with the end of a template nucleic acid molecule and identifies an origin of the template nucleic acid molecule.
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Abstract
An embodiment of an identifier element for identifying an origin of a template nucleic acid molecule is described that comprises a nucleic acid element comprising a sequence composition that enables detection of an introduced error in sequence data generated from the nucleic acid element and correction of the introduced error, where the nucleic acid element is constructed to couple with the end of a template nucleic acid molecule and identifies an origin of the template nucleic acid molecule.
510 Citations
51 Claims
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1. An identifier element for identifying an origin of a template nucleic acid molecule, comprising:
a nucleic acid element comprising a sequence composition that enables detection of an introduced error in sequence data generated from the nucleic acid element and correction of the introduced error, wherein the nucleic acid element is constructed to couple with the end of a template nucleic acid molecule and identifies an origin of the template nucleic acid molecule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for identifying an origin of a template nucleic acid molecule, comprising the steps of:
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identifying a first identifier sequence from sequence data generated from a template nucleic acid molecule; detecting an introduced error in the first identifier sequence; correcting the introduced error in the first identifier sequence; associating the corrected first identifier sequence with a first identifier element coupled to the template molecule; and identifying an origin of the template molecule using the association of the corrected first identifier sequence with the first identifier element. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A kit for identifying an origin of a template nucleic acid molecule comprising:
a set of nucleic acid elements each comprising a distinctive sequence composition that enables detection of an introduced error in sequence data generated from each nucleic acid element and correction of the introduced error, wherein each of the nucleic acid elements is constructed to couple with the end of a template nucleic acid molecule and identifies the origin of the template nucleic acid molecule. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42)
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43. A computer, comprising executable code stored thereon, wherein the executable code performs a method for identifying an origin of a template nucleic acid molecule, comprising the steps of:
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identifying an identifier sequence from sequence data generated from a template nucleic acid molecule; detecting an introduced error in the identifier sequence; correcting the introduced error in the identifier sequence; associating the corrected identifier sequence with an identifier element coupled with the template molecule; and identifying an origin of the template molecule using the association of the corrected identifier sequence with the identifier element. - View Dependent Claims (44, 45, 46, 48, 49, 50, 51)
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Specification