Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma

• US 20090107001A1
• Filed: 09/16/2008
• Published: 04/30/2009
• Est. Priority Date: 03/19/2007
• Status: Abandoned Application

• Current Assignee: Hemcon Life Sciences, Inc.
• Original Assignee: Hemcon Medical Technologies Inc. (Tricol International Group Ltd.)
• Inventors: McCarthy, Simon J.
• Application Number:
  US12/283,885
• Publication Number:
  US 20090107001A1
• Time in Patent Office: Days
• US Class Current: 34/284
• CPC Class Codes: A61B 50/10 Furniture specially adapted for surgical or diagnostic appliances or instruments
• CPC Class Codes: A61B 50/13 Trolleys, e.g. carts
• CPC Class Codes: A61B 50/30 Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments for wound clamps A61B17/10; for ligaturing clips A61B17/122; packages or dispensers for surgical gloves or finger-stalls A61B42/40
• CPC Class Codes: A61B 90/96 using barcodes
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 1/1475 Inlet or outlet ports
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2027 having frangible parts
• CPC Class Codes: A61J 1/2037 having valve means
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: A61M 2039/1061 Break-apart tubing connectors or couplings
• CPC Class Codes: A61P 7/08 Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock artificial tears A61P27/04
• CPC Class Codes: F26B 5/06 the process involving freezing

Abstract

Single unit human plasma is dispensed from a source transfer bag into a receptacle in which the plasma under goes freeze-drying. During the dispensing of the plasma from the source transfer container into the freeze-drying receptacle, an inline treatment device treats the plasma prior to freeze-drying, e.g., by the removal of cellular blood components, or by the removal of pathogens or viral or bacterial agents, or by the removal or neutralization of blood group specific antibodies.

Claims

1. A method of freeze-drying a plasma comprising the steps of:

providing a source of single unit Type A plasma,

treating the single unit Type A plasma by exposing the plasma to an antigen for removing or neutralizing B antibodies from the type A plasma,

after the treating, transferring the treated single unit Type A plasma from the source into a receptacle; and

freeze-drying the treated plasma within the receptacle.

2. A method according to claim 1

wherein the single unit Type A plasma comprises single donor plasma.

3. A system comprising

a source of single unit Type A plasma,

a freeze-drying receptacle for the single unit Type A plasma, and

a path for transferring the single unit Type A plasma from the source into the receptacle, the path including a treatment device comprising an antigen for removing or neutralizing B antibodies from the type A plasma.

4. A system according to claim 3

wherein the single unit Type B plasma comprises single donor plasma.

5. A method of freeze-drying a plasma comprising the steps of:

providing a source of single unit Type B plasma,

treating the single unit Type B plasma by exposing the plasma to an antigen for removing or neutralizing A antibodies from the type B plasma,

after the treating, transferring the treated single unit Type B plasma from the source into a receptacle; and

freeze-drying the treated plasma within the receptacle.

6. A method according to claim 5

wherein the single unit Type B plasma comprises single donor plasma.

7. A system comprising

a source of single unit Type B plasma,

a freeze-drying receptacle for the single unit Type B plasma, and

a path for transferring the single unit Type B plasma from the source into the receptacle, the path including a treatment device comprising an antigen for removing or neutralizing A antibodies from the type B plasma.

8. A system according to claim 7

wherein the single unit Type B plasma comprises single donor plasma.

9. A method of freeze-drying a plasma comprising the steps of:

providing a source of single unit plasma,

treating the single unit plasma by removal of a targeted material from the plasma,

after the treating, transferring the treated single unit plasma from the source into a receptacle; and

freeze-drying the treated plasma within the receptacle.

10. A method according to claim 9

wherein the single unit plasma comprises single donor plasma.

11. A system comprising

a source of single unit plasma carrying an undesired material,

a freeze-drying receptacle for the single unit plasma, and

a path for transferring the single unit plasma from the source into the receptacle, the path including a treatment device for removing the undesired material from the plasma.

12. A system according to claim 11

wherein the single unit plasma comprises single donor plasma.