DEVICE FOR INHALATION OF MEDICINE

• US 20090107495A1
• Filed: 07/21/2006
• Published: 04/30/2009
• Est. Priority Date: 07/21/2005
• Status: Abandoned Application

• Current Assignee: National Institute for Materials Science
• Original Assignee: National Institute for Materials Science
• Inventors: Ni, Henmei, Uchida, Yoshiyuki, Kamimura, Wataru, Tanaka, Junzo
• Application Number:
  US11/996,431
• Publication Number:
  US 20090107495A1
• Time in Patent Office: Days
• US Class Current: 128/203.150
• CPC Class Codes: A61K 9/0075 for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
• CPC Class Codes: A61K 9/1688 resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61K 9/51 Nanocapsules; Nanoparticles; nanotubes A61K9/0092; polymeric micelles A61K9/1075; polymersomes A61K9/1273; pure drug nanoparticles A61K9/14; drug nanoparticles with adsorbed surface modifiers A61K9/141; conjugates, e.g. between drug and non-active nanoparticles, A61K47/50; preparations for in vivo diagnosis A61K49/00; with radioactive substances A61K51/00
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology

Abstract

An object of the present invention is to provide an inhalation device by which nano-sized particles of a medicine are able to be stably present without aggregation even in air or the like where no dispersing solvent is present. A device for inhalation of medicine according to the present invention for solving such a problem is that where medicine particles in a nano- to micron-size are adhered to a matrix comprising a nano fiber to such an extent that the particles are detached by inspiration permeating through the matrix.

Claims

1. A device for inhalation of medicine where medicine particles in a nano- to micron-size are adhered to a matrix comprising a nano fiber to such an extent that the particles are detached by inspiration permeating through the matrix.

2. The device for inhalation of medicine according to claim 1, wherein said nano fiber comprises a macromolecular material.

3. The device for inhalation of medicine according to claim 2, wherein said macromolecular material is polyvinylpyrrolidone or polyvinylalcohol.

4. The device for inhalation of medicine according to any one of claims 1 to 3, wherein said matrix comprising a nano fiber is formed on the surface of a fiber carrier.

5. The device for inhalation of medicine according to claim 4, wherein said fiber carrier is an organic fiber carrier.

6. The device for inhalation of medicine according to claim 5, wherein said organic fiber carrier is a cotton mat.

7. A method for the manufacture of the device for inhalation of medicine where a solution containing a medicine is spray-dried onto a matrix comprising a nano fiber whereby medicine particles in a nano- to micron-size are adhered on the surface of the nano fiber to such an extent that the particles are detached by inspiration permeating through the matrix.

8. The method for the manufacture according to claim 7, wherein an electrospinning by using a solution of macromolecule as a starting material is carried out to form a matrix comprising a nano fiber.

9. The method for the manufacture according to claim 8, wherein, said matrix comprising a nano fiber is formed on the surface of a fiber carrier.

10. The method for the manufacture according to claim 9, wherein said fiber carrier is placed on an electroconductive metal foil and an electrospinning is carried out by applying voltage between a nozzle and the electroconductive metal foil to form a matrix comprising a nano fiber which comprises a macromolecular material on the surface of said fiber carrier.

11. A mask for inhalation of medicine where a device for inhalation of medicine that medicine particles in a nano- to micron-size are adhered to a matrix comprising a nano fiber and formed on the surface of a fiber carrier to such an extent that the particles are detached by inspiration permeating through the matrix is made into a shape of a mask.