APPARATUS AND METHOD FOR FORMING A GAS COMPOSITION GRADIENT BETWEEN FAIMS ELECTRODES

• US 20090108195A1
• Filed: 02/17/2006
• Published: 04/30/2009
• Est. Priority Date: 02/17/2005
• Status: Active Grant

• Current Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Original Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Inventors: Thekkadath, Govindanunny, Guevremont, Roger
• Granted Patent: US 7,714,282 B2
• Time in Patent Office: Days
• US Class Current: 250/282
• CPC Class Codes: H01J 49/42 Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons

Abstract

A method of separating ions includes providing a FAIMS analyzer region for separating ions, the FAIMS analyzer region in fluid communication with an ionization source and with an ion detecting device. The method further includes affecting a gas composition within a first portion of the FAIMS analyzer region to be different from a gas composition within a second portion of the FAIMS analyzer region. The establishment of a gas composition gradient within the FAIMS analyzer region enhances ion focusing and ion transport efficiency.

Claims

1. An apparatus for separating ions, comprising:

a first electrode and a second electrode disposed one relative to the other in a spaced-apart facing arrangement for defining an analyzer region therebetween, the analyzer region including a first end and a second end and having a length extending between the first end and the second end;

a first gas inlet in fluid communication with the analyzer region, for providing a flow of a carrier gas of a first composition;

a second gas inlet in fluid communication with the analyzer region, for providing a flow of a carrier gas of a second composition; and

,

a gas-flow directing element in fluid communication with the first gas inlet and in fluid communication with the second gas inlet, for receiving the flow of the carrier gas of the first composition and the flow of the carrier gas of the second composition, and for providing within a portion of the analyzer region a carrier gas flow having a composition that is non-uniform in space.

2. An apparatus according to claim 1, wherein during use the carrier gas flow within the portion of the analyzer region has substantially the first composition adjacent the first electrode and substantially the second composition adjacent the second electrode.

3. An apparatus according to claim 2, wherein during use the composition of the carrier gas flow varies across the analyzer region between the first electrode and the second electrode along a direction transverse to the length.

4. An apparatus according to claim 1, wherein the gas-flow directing element comprises a plurality of plate structures that are disposed in a stacked, spaced-apart arrangement.

10. An apparatus according to claim 1, wherein the first electrode and the second electrode each comprise a flat-plate electrode body.

11. An apparatus according to claim 1, wherein the gas-flow directing element comprises a diffuser that is disposed for restricting the flow of the carrier gas of the first composition and for restricting the flow of the carrier gas of the second composition.

17. An apparatus according to claim 1, comprising an electrical contact on one of the first electrode and the second electrode for receiving an electrical signal from a power supply for applying an asymmetric waveform voltage to the one of the first electrode and the second electrode, and for providing a direct current voltage difference between the first electrode and the second electrode.

18. An apparatus according to claim 1, wherein the analyzer region is a high field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer region.

19. An apparatus according to claim 1, wherein the gas-flow directing element comprises a plurality of axially aligned, cylindrical plate structures that are disposed in a radially spaced-apart arrangement.

5-9. -9. (canceled)

12-16. -16. (canceled)

20-41. -41. (canceled)

42. A method of separating ions, comprising:

providing a high field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer region for separating ions;

providing a flow of a carrier gas within a portion of the FAIMS analyzer region, the flow of carrier gas having a composition that is non-uniform in space along a direction transverse to the flow of the carrier gas;

introducing ions into the FAIMS analyzer region;

providing electric field conditions within the FAIMS analyzer region for selectively transmitting a subset of the ions through the FAIMS analyzer region; and

,

selectively transmitting the subset of ions along an average ion flow path through the FAIMS analyzer region.

43. A method according to claim 42, wherein providing a flow of carrier gas within a portion of the FAIMS analyzer region comprises providing a flow of a first gas and providing separately a flow of a second gas.

44. A method according to claim 43, wherein a composition of the flow of the first gas is different than a composition of the flow of the second gas.

45. A method according to claim 42, wherein at least one of the flow of the first gas and the flow of the second gas is a flow of a single component gas.

46. A method according to 42, wherein at least one of the flow of the first gas and the flow of the second gas is a flow of a mixed gas.

47. A method according to claim 43, wherein providing a FAIMS analyzer region for separating ions comprises providing a first electrode surface and a second electrode surface that is spaced-apart from the first electrode surface and facing the first electrode surface, the first electrode surface substantially parallel to the second electrode surface.

48. A method according to claim 47, wherein providing a flow of the first gas comprises directing the first gas to flow adjacent and substantially parallel to the first electrode surface.

49. A method according to claim 48, wherein providing a flow of the second gas comprises directing the second gas to flow adjacent and substantially parallel to the second electrode surface.

50. A method according to claim 49, comprising directing the first gas flow and directing the second gas flow absent forming a carrier gas flow having a homogeneous composition.

51. A method according to claim 49, comprising directing the first gas flow and directing the second gas flow absent substantial mixing between the first gas flow and the second gas flow within the portion of the FAIMS analyzer region.

52. A method according to claim 49, comprising providing a gas flow directing element for affecting the first gas flow and the second gas flow prior to introduction into the portion of the analyzer region.

53. A method according to claim 49, comprising providing a gas flow directing element for providing substantially laminar flow of the first gas adjacent the first electrode surface and for providing substantially laminar flow of the second gas adjacent the second electrode surface.

54. A method according to claim 48, comprising providing a diffuser that is disposed between a gas source region and the portion of the analyzer region for restricting the flow of the first gas and for restricting the flow of the second gas.

55. A method according to claim 48, comprising disposing a diffuser between a gas source region and the portion of the analyzer region for equilibrating a pressure of the first gas and equilibrating a pressure of the second gas prior to introduction into the portion of the analyzer region.

58. A method according to claim 43, wherein the carrier gas composition that is non-uniform in space comprises a composition gradient extending between a portion that is enriched in the first gas proximate the first electrode surface and a portion that is enriched in the second gas proximate the second electrode surface.

59. A method according to claim 58, wherein a volume fraction of the first gas in the carrier gas decreases with increasing separation from the first electrode surface.

60. A method according to claim 42, wherein selectively transmitting the subset of ions along an average ion flow path through the analyzer region comprises entraining the subset of ions in the flow of a carrier gas.

61. A method according to claim 42, wherein selectively transmitting the subset of ions along an average ion flow path through the analyzer region comprises providing an electric field gradient directed along a direction opposite the flow of carrier gas for causing the subset of ions to drift along the direction opposite the flow of carrier gas.

56. (canceled)

57. (canceled)

62. A method of separating ions, comprising:

providing a high field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer region for separating ions, the FAIMS analyzer region comprising an ion origin end that is in fluid communication with an ionization source, and an ion exit end that is in fluid communication with an ion detecting device, a length of the FAIMS analyzer region defined along a direction between the ion origin end and the ion detection end;

providing a flow of a first gas into a gas inlet region of the FAIMS analyzer region; and

,

providing separately a flow of a second gas into the gas inlet region of the FAIMS analyzer region, and absent forming a homogeneous carrier gas flow including the first gas and the second gas within the gas inlet region.