METHOD FOR THE PRODUCTION OF BIO-IMAGING NANOPARTICLES WITH HIGH YIELD BY EARLY INTRODUCTION OF IRREGULAR STRUCTURE
First Claim
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1. A method of preparing bio-imaging nanoparticles which comprises:
- 1) adding 1 to 30 equivalents of an organic ligand, which contains a thiol group and a hydrophilic group being linked by a hydrocarbon chain of from 8 to 20 carbon atoms, to core or core/shell hydrophobic inorganic nanoparticles protected with surfactants, under conditions effective to partially replace the surfactants with organic ligands and thereby form a metal-thiolate (M-S) bond on the surface of nanoparticles, resulting in preparing hydrophobic nanoparticles whose surface is only partially modified to hydrophilic, while still maintaining their individual dispersibility in a nonpolar organic solvent;
2) bonding functional molecules to the hydrophilic groups introduced onto the surface of nanoparticles prepared in step
1), to afford functionality and an irregular structure to the surface of nanoparticles, while maintaining their individual dispersibility; and
3) replacing the rest of the surfactants remaining on the surface of nanoparticles prepared in step
2) with organic ligands where at least two hydrophilic groups are linked by a hydrocarbon chain of from 1 to 7 carbon atoms, thereby converting the hydrophobic nanoparticles into hydrophilic ones.
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Abstract
Methods of preparing bio-imaging nanoparticles having high dispersibility in an aqueous solution, biocompatibility, and targetability with high yield, by early introduction of an irregular structure are disclosed.
26 Citations
16 Claims
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1. A method of preparing bio-imaging nanoparticles which comprises:
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1) adding 1 to 30 equivalents of an organic ligand, which contains a thiol group and a hydrophilic group being linked by a hydrocarbon chain of from 8 to 20 carbon atoms, to core or core/shell hydrophobic inorganic nanoparticles protected with surfactants, under conditions effective to partially replace the surfactants with organic ligands and thereby form a metal-thiolate (M-S) bond on the surface of nanoparticles, resulting in preparing hydrophobic nanoparticles whose surface is only partially modified to hydrophilic, while still maintaining their individual dispersibility in a nonpolar organic solvent; 2) bonding functional molecules to the hydrophilic groups introduced onto the surface of nanoparticles prepared in step
1), to afford functionality and an irregular structure to the surface of nanoparticles, while maintaining their individual dispersibility; and3) replacing the rest of the surfactants remaining on the surface of nanoparticles prepared in step
2) with organic ligands where at least two hydrophilic groups are linked by a hydrocarbon chain of from 1 to 7 carbon atoms, thereby converting the hydrophobic nanoparticles into hydrophilic ones. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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