Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms
First Claim
1. A linker for connecting with one or more dosage form units from a group including capsule compartments and closure caps, the linker being configured to include a drug substance and comprising:
- a solid drug substance in tablet form, the tablet having a longitudinal axis and being substantially cylindrical with opposed axial end faces;
a jacket radially confining the tablet, the jacket having an outer wall with longitudinal ends, at least one of the jacket longitudinal ends being open for dispensing the drug substance from the respective end face,wherein the outer wall further includes a snap-fit element located adjacent at least one jacket longitudinal end.
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Accused Products
Abstract
A linker for multicomponent dosage form has a preformed drug substance tablet and an injection molded jacket including one or both axial jacket ends open for dispensing the preformed drug substances. The jacket has snap-fit connection elements on the outer surface adjacent each end for engagement with complementary snap-fit element on capsule-type and cap-type dosage form units. Another multicomponent drug form linker is injection molded with a raised circumferential band and snap-fit elements between the band and respective ends engageable with complementary snap-fit elements on dosage form units to provide compressive abutting contact between ends of the units and the band. The band can have an axially tapered outer surface to accommodate dosage form units of different diameters. Still another multicomponent dosage form linker has separable male and female parts each engageable with, and separately sealing, respective dosage form units to be linked. Circumferential complementary grooves, groove segments, ridges and ridge segment-type snap-fit elements are disclosed, as are dosage forms using the above-described linkers.
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Citations
41 Claims
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1. A linker for connecting with one or more dosage form units from a group including capsule compartments and closure caps, the linker being configured to include a drug substance and comprising:
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a solid drug substance in tablet form, the tablet having a longitudinal axis and being substantially cylindrical with opposed axial end faces; a jacket radially confining the tablet, the jacket having an outer wall with longitudinal ends, at least one of the jacket longitudinal ends being open for dispensing the drug substance from the respective end face, wherein the outer wall further includes a snap-fit element located adjacent at least one jacket longitudinal end. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A multicomponent dosage form comprising:
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a linker unit including a solid drug substance in tablet form, the tablet having a longitudinal axis and being substantially cylindrical with opposed longitudinal end faces; a jacket radially confining the tablet, the jacket having an outer wall with longitudinal ends and a raised circumferential band between the jacket longitudinal ends, and wherein the outer wall further includes a snap-fit element located adjacent at least one longitudinal end, the element being selected from circumferential grooves, groove segments, ridges and ridge segments; and at least one dosage form unit selected from the group including capsule compartments and closure caps, the dosage form unit having an open end connected to the one jacket longitudinal end, the unit having a snap-fit element complementary to and configured to engage the snap-fit element adjacent the one jacket longitudinal end. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. A multicomponent dosage product comprising:
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a linker unit including a solid drug substance in tablet form, the tablet having a longitudinal axis and being substantially cylindrical with opposed longitudinal end faces; a jacket radially confining the tablet, the jacket having an outer wall with opposed longitudinal ends and a raised circumferential band between the jacket ends, wherein the outer wall further includes a snap-fit element located between the raised circumferential band and one of the longitudinal ends, the snap-fit element being selected from circumferential grooves, groove segments, ridges, and ridge segments; and a first capsule compartment having an open end connected to the linker unit at the one jacket longitudinal end, the first capsule compartment having a snap-fit element complementary to and engaging the snap-fit element of the one jacket longitudinal end, wherein the first capsule compartment contains a first drug substance different in composition and/or in release characteristics from the tablet drug substance. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A linker for connecting two dosage form units from the group including capsule compartments and closure caps, the dosage form units each having an open end, the linker comprising:
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a substantially cylindrical tube having an interior and a longitudinal axis, the tube also having an outer surface and opposed axial ends; a raised band disposed on the tube outer surface, the band being located between the opposed axial tube ends and extending circumferentially around the tube outer surface, the raised band having opposed side surfaces configured for compressive abutting contact with the open ends of the dosage form units; snap-fit elements located on the tube outer surface between the raised band and a respective tube axial end, the snap-fit elements being selected from circumferential grooves, groove segments, ridges, and ridge segments; and a wall configured to close the tube interior, the wall being positioned along the axis at a location at one of, or between, the tube axial ends.
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37. A dosage form comprising:
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a linker comprising a substantially cylindrical tube having an interior and a longitudinal axis, the tube also having an outer surface and opposed axial ends; a raised band positioned on the outer surface, the band being located between the opposed axial tube ends and extending circumferentially around the tube outer surface, the raised band having opposed side surfaces oriented substantially perpendicular to the axis; snap-fit elements located on the tube outer surface between the raised band and a respective tube axial end, the snap-fit elements being selected from circumferential grooves, groove segments, ridges, and ridge segments; a wall configured and dimensioned to close the tube, the wall being positioned along the axis one of, or between, the tube axial ends; and a pair of dosage form units selected from capsule compartments and closure caps connected to the linker axial ends, each of said units having a complementary snap-fit element formed on a respective inner unit surface adjacent an open end and being engaged with a respective snap-fit element on the linker, wherein the configuration of the snap-fit elements and spacing from the raised band on the linker and the configuration of the complementary snap-fit elements and spacing from the open ends on the dosage form units provides a compressive abutting contact between the open ends of the dosage form units and the respective sides of the raised band.
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38. A linker for connecting and separately sealing first and second capsule compartments, the linker comprising:
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a first generally cylindrical linker part having an axis and opposed longitudinal ends, the first part also having an outer surface with a diameter, an inner surface with a diameter, and a closed wall, the outer surface including a first snap-fit element configured for engaging a complementary snap-fit element on the first capsule compartment, and the inner surface including another snap-fit element, the first snap-fit element and the another snap-fit element being selected from circumferential grooves, groove segments, ridges, and ridge segments; and a second generally cylindrical linker part having an axis and opposed longitudinal ends, the second linker part having a large diameter portion adjacent a first end of the second part and a small diameter portion adjacent and extending axially from a second end of the second part, the large and small diameter portions having respective outer surfaces, the second part also having a closed wall, wherein the outer surface of the large diameter portion includes a second snap-fit element configured for engaging a complementary snap-fit element on the second capsule compartment, the second snap-fit element being selected from circumferential grooves, groove segments, ridges, and ridge segments, wherein the outer surface of the small diameter portion contains a snap-fit element selected from circumferential grooves, groove segments, ridges, and ridge segments complementary to the another snap-fit element on the inner surface of the first linker part.
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39. A linker for connecting and substantially separately sealing a first and a second capsule compartment comprising:
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a first linker part including a first axial end and a second axial end and including first and second snap-fit elements disposed adjacent a respective one of the first and second axial ends thereof; a second linker part include a first axial end and a second axial end and including third and fourth snap-fit elements disposed adjacent a respective one of the first and second axial ends thereof; wherein the first snap-fit element is configured to selectively engage a complementary snap-fit element on the first capsule compartment, the fourth snap-fit element is configured to selectively engage a complementary snap-fit element on the second capsule compartment, and the second snap-fit element is configured to be complementary to and selectively engageable with the third snap-fit element.
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40. An apparatus for containing a drug substance comprising:
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a linker element having a generally cylindrical outer wall, a first snap-fit element disposed on an outer surface thereof and at least one closed axial end wall; and a capsule compartment having a generally cylindrical outer wall, a first complementary snap-fit element disposed on an inner surface thereof, a closed axial end and an open axial end; wherein the first snap fit element and first complementary snap-fit element are selectively engageable; and wherein the linker element is configured to substantially seal the drug substance within a region defined by at least the linker outer wall and the closed axial end of the capsule compartment and the closed axial end wall of the linker element when the first snap-fit element and the first complementary snap-fit element are engaged.
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41. A dosage form comprising:
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a first generally cylindrical capsule compartment having an axis, a closed end, and an open end, the open end including an integral, annular linker member extending axially outward of the open end and having an outer surface with a first snap-fit element located a distance L1 from the capsule compartment open end; a second generally cylindrical capsule compartment having an axis, a closed end, and an open end with an inner surface, the second capsule compartment having a second snap-fit element complementary to the first snap-fit element, the second snap-fit element being located on the inner surface and spaced a distance of L2 from the second capsule open end, wherein L2>
L1 and the first and second snap-fit elements are engageable to connect the first and second capsule compartments with the respective open ends being in compressive abutting contact with each other.
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Specification