Chromosome selection

• US 20090111184A1
• Filed: 10/24/2007
• Published: 04/30/2009
• Est. Priority Date: 10/24/2007
• Status: Abandoned Application

• Current Assignee: Searete LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Myhrvold, Nathan P., Langer, Robert, Hillis, W. Daniel, Jung, Edward K.Y., Wood, Lowell L. JR., Hyde, Roderick A.
• Application Number:
  US11/977,529
• Publication Number:
  US 20090111184A1
• Time in Patent Office: Days
• US Class Current: 435/455
• CPC Class Codes: C12N 15/873 Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
• CPC Class Codes: C12Q 1/6883 for diseases caused by alterations of genetic material

Abstract

Systems, methods, compositions and apparatus relating to genome, chromosome, and mitochondria selection are disclosed.

Claims

1. A method comprising:

selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more homologues; and

providing the one or more selected chromosomal homologues to one or more germ line cells.

2. The method of claim 1, further comprising:

obtaining the one or more homologues of the one or more chromosomes.

3. The method of claim 2, wherein obtaining the one or more homologues of the one or more chromosomes comprises:

obtaining the one or more homologues of the one or more chromosomes from one or more second germ line cells.

4. The method of claim 3, wherein the one or more germ line cells are one or more haploid germ cells.

5. The method of claim 3, wherein the one or more germ line cells are one or more spermatogonia.

6. The method of claim 3, wherein the one or more germ line cells are one or more oocytes.

7. The method of claim 3, wherein the one or more germ line cells are one or more polar bodies.

8. The method of claim 3, wherein the one or more germ line cells are one or more stem cells.

9. The method of claim 2, wherein obtaining the one or more homologues of the one or more chromosomes comprises:

obtaining the one or more homologues of at least one chromosome.

10. The method of claim 2, wherein obtaining the one or more homologues of the one or more chromosomes comprises:

obtaining at least one homologue of the one or more chromosomes.

11. The method of claim 2, wherein obtaining the one or more homologues of the one or more chromosomes comprises:

obtaining at most two homologues of the one or more chromosomes.

12. The method of claim 2, wherein obtaining the one or more homologues of the one or more chromosomes comprises:

obtaining the one or more homologues of the one or more chromosomes from one or more somatic cells.

13. The method of claim 12, wherein the one or more somatic cells are one or more stem cells.

14. The method of claim 12, wherein the one or more somatic cells are one or more progenitor cells.

15. The method of claim 1, wherein the one or more chromosomes are one or more autosomal chromosomes.

16. The method of claim 1, wherein the one or more chromosomes are one or more gonosomal chromosomes.

17. The method of claim 1, wherein the one or more chromosomes are human chromosomes selected from the group consisting of chromosome I, chromosome II, chromosome IIII, chromosome IV, chromosome V, chromosome VI, chromosome VII, chromosome VIII, chromosome IX, chromosome X, chromosome XI, chromosome XII, chromosome XIII, chromosome XIV, chromosome XV, chromosome XVI, chromosome XVII, chromosome XVIII, chromosome XIX, chromosome XX, chromosome XXI, chromosome XXII, and XXIII.

18. The method of claim 1, wherein the one or more germ line cells are one or more haploid germ cells.

19. The method of claim 1, wherein the one or more germ line cells are one or more spermatogonia.

20. The method of claim 1, wherein the one or more germ line cells are one or more oocytes.

21. The method of claim 1, wherein the one or more germ line cells are one or more stem cells.

22. The method of claim 1, wherein selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more homologues comprises:

selecting the one or more chromosomal homologues at least partially based on one or more alleles of one or more genes of the one or more chromosomal homologues.

23. The method of claim 1, wherein selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more homologues comprises:

selecting one or more homologues of one or more second chromosomes at least partially based on one or more genetic characteristics of the one or more selected chromosomal homologues.

24. The method of claim 23, wherein selecting one or more homologues of one or more second chromosomes at least partially based on one or more genetic characteristics of the one or more selected chromosomal homologues comprises:

selecting the one or more second chromosomal homologues at least partially based on one or more alleles of one or more genes of the one or more selected chromosomal homologues.

25. The method of claim 1, wherein selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more homologues comprises:

selecting the one or more chromosomal homologues at least partially based on one or more genetic characteristics of one or more reference chromosomes.

26. The method of claim 1, wherein selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more homologues comprises:

selecting the one or more chromosomal homologues at least partially based on one or more genetic characteristics of one or more target chromosomes.

27. The method of claim 1, wherein selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more homologues comprises:

selecting the one or more chromosomal homologues at least partially based on one or more genetic characteristics of the one or more germ line cells.

28. The method of claim 1, wherein selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more homologues comprises:

selecting the one or more chromosomal homologues at least partially based on one or more genetic characteristics of one or more related germ line cells.

29. The method of claim 28, wherein the one or more related germ line cells are selected from the group consisting of one or more related polar bodies and one or more related spermatids.

30. The method of claim 1, wherein selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more homologues comprises:

selecting the one or more chromosomal homologues at least partially based on one or more genetic characteristics of one or more second germ line cells, wherein the one or more second germ line cells and the one or more germ line cells are from a single donor.

31. The method of claim 1, wherein selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more homologues comprises:

selecting the one or more chromosomal homologues at least partially based on one or more genetic characteristics of one or more somatic cells, wherein the one or more somatic cells and the one or more germ line cells are from a single donor.

32. The method of claim 1, wherein selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more homologues comprises:

selecting the one or more chromosomal homologues at least partially based on one or more genetic characteristics of one or more second germ line cells, wherein the one or more second germ line cells and the one or more germ line cells are from a different donor.

33. The method of claim 32, further comprising:

providing the one or more germ line cells to the one or more second germ line cells for fertilization.

34. The method of claim 32, further comprising:

combining the one or more germ line cells with the one or more second germ line cells for fertilization.

35. The method of claim 1, wherein selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more homologues comprises:

selecting the one or more chromosomal homologues at least partially based on one or more genetic characteristics of mitochondrial DNA.

36. The method of claim 35, wherein selecting the one or more chromosomal homologues at least partially based on one or more genetic characteristics of mitochondrial DNA comprises:

selecting the one or more chromosomal homologues at least partially based on the one or more genetic characteristics of mitochondrial DNA in the one or more germ line cells.

37. The method of claim 35, wherein selecting the one or more chromosomal homologues at least partially based on one or more genetic characteristics of mitochondrial DNA comprises:

selecting the one or more chromosomal homologues at least partially based on the one or more genetic characteristics of mitochondrial DNA in one or more second germ line cells, wherein the one or more second germ line cells and the one or more germ line cells are from a different donor.

38. A method for optimizing one or more germ cells comprising:

selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more chromosomal homologues; and

providing the one or more selected chromosomal homologues to the one or more germ cells.

39. The method of claim 38, further comprising:

obtaining the one or more homologues of the one or more chromosomes.

40. A method for treating or preventing one or more genetic diseases comprising:

selecting one or more homologues of one or more chromosomes at least partially based on one or more genetic characteristics of the one or more chromosomal homologues;

wherein one or more unselected homologues of the one or more selected chromosomal homologues have been associated with the one or more genetic diseases; and

providing the one or more selected chromosomal homologues to one or more germ line cells.

41. The method of claim 40, further comprising:

removing the one or more chromosomal homologues from the one or more germ line cells.

42. A composition of matter comprising:

one or more optimized germ line cells, the optimized germ cells having one or more homologues of one or more chromosomes individually selected at least partially based on one or more genetic characteristics of the one or more chromosomal homologues.