Delivery of Active Agents
First Claim
1. A method of providing an active agent to a patient in need thereof comprising:
- selecting an active agent subject to degradation in said patient wherein the effectiveness of said active agent is reduced by said degradation;
associating said active agent with a diketopiperazine to produce a pharmaceutical composition suitable for pulmonary inhalation; and
providing said pharmaceutical composition to said patient.
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Accused Products
Abstract
A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site.
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Citations
19 Claims
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1. A method of providing an active agent to a patient in need thereof comprising:
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selecting an active agent subject to degradation in said patient wherein the effectiveness of said active agent is reduced by said degradation; associating said active agent with a diketopiperazine to produce a pharmaceutical composition suitable for pulmonary inhalation; and providing said pharmaceutical composition to said patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of treating disease comprising:
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selecting a patient being treated with or a patient with a condition treatable by a labile active agent; providing a composition comprising said labile active agent in association with a diketopiperazine; and administering said composition to said patient via pulmonary inhalation; thereby treating said disease or condition. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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Specification