Mitochondrial selection

• US 20090111764A1
• Filed: 10/25/2007
• Published: 04/30/2009
• Est. Priority Date: 10/25/2007
• Status: Abandoned Application

• Current Assignee: Searete LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Myhrvold, Nathan P., Langer, Robert, Hillis, W. Daniel, Jung, Edward K.Y., Wood, Lowell L. JR., Hyde, Roderick A.
• Application Number:
  US11/977,528
• Publication Number:
  US 20090111764A1
• Time in Patent Office: Days
• US Class Current: 514/44.R
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047

Abstract

Systems, methods, compositions and apparatus relating to genome, chromosome, and mitochondria selection are disclosed.

Claims

1. A method comprising:

selecting one or more variants of mitochondrial chromosomes at least partially based on one or more genetic characteristics of the one or more variants;

providing the one or more selected mitochondrial chromosome variants to one or more female germ line cells.

2. The method of claim 1, further comprising:

obtaining the one or more variants of mitochondrial chromosomes.

3. The method of claim 2, wherein obtaining the one or more variants of mitochondrial chromosomes comprises:

obtaining the one or more mitochondrial chromosome variants from one or more second germ line cells.

4. The method of claim 3, wherein the one or more germ line cells are one or more haploid germ cells.

5. The method of claim 3, wherein the one or more germ line cells are one or more spermatogonia.

6. The method of claim 3, wherein the one or more germ line cells are one or more oocytes.

7. The method of claim 3, wherein the one or more germ line cells are one or more stem cells.

8. The method of claim 2, wherein obtaining the one or more variants of mitochondrial chromosomes comprises:

obtaining the one or more mitochondrial chromosome variants from one or more somatic cells.

9. The method of claim 8, wherein the one or more somatic cells are one or more stem cells.

10. The method of claim 8, wherein the one or more somatic cells are one or more progenitor cells.

11. The method of claim 8, wherein the one or more somatic cells are one or more lymphocytes.

12. The method of claim 1, wherein the one or more female germ line cells are one or more oocytes.

13. The method of claim 1, wherein the one or more female germ line cells are one or more stem cells.

14. The method of claim 1, selecting one or more variants of mitochondrial chromosomes at least partially based on one or more genetic characteristics of the one or more variants comprises:

selecting the one or more mitochondrial chromosome variants at least partially based on one or more alleles of one or more genes of the one or more mitochondrial chromosome variants.

15. The method of claim 1, selecting one or more variants of mitochondrial chromosomes at least partially based on one or more genetic characteristics of the one or more variants comprises:

selecting one or more second mitochondrial chromosome variants at least partially based on the one or more genetic characteristics of the one or more selected mitochondrial chromosome variants.

16. The method of claim 15, wherein selecting the one or more second mitochondrial chromosome variants at least partially based on the one or more genetic characteristics of the one or more selected mitochondrial chromosome variants comprises:

selecting the one or more second mitochondrial chromosome variants at least partially based on one or more alleles of one or more genes of the one or more selected mitochondrial chromosome variants.

17. The method of claim 1, selecting one or more variants of mitochondrial chromosomes at least partially based on one or more genetic characteristics of the one or more variants comprises:

selecting the one or more mitochondrial chromosome variants at least partially based on one or more genetic characteristics of one or more reference mitochondrial chromosomes.

18. The method of claim 1, wherein selecting one or more variants of mitochondrial chromosomes at least partially based on one or more genetic characteristics of the one or more variants comprises:

selecting the one or more mitochondrial chromosome variants at least partially based on one or more genetic characteristics of one or more target mitochondrial chromosomes.

19. The method of claim 1, wherein selecting one or more variants of mitochondrial chromosomes at least partially based on one or more genetic characteristics of the one or more variants comprises:

selecting the one or more mitochondrial chromosome variants at least partially based on one or more genetic characteristics of the one or more female germ line cells.

20. The method of claim 19, wherein the one or more genetic characteristics of the one or more female germ line cells include one or more genetic characteristics of one or more mitochondrial chromosome variants of the one or more female germ line cells.

21. The method of claim 1, selecting one or more variants of mitochondrial chromosomes at least partially based on one or more genetic characteristics of the one or more variants comprises:

selecting the one or more mitochondrial chromosome variants at least partially based on one or more genetic characteristics of one or more somatic cells, wherein the one or more somatic cells and the one or more female germ line cells are from a single donor.

22. The method of claim 21, wherein the one or more genetic characteristics of the one or more somatic cells include one or more genetic characteristics of one or more mitochondrial chromosome variants of the one or more somatic cells.

23. The method of claim 1, wherein selecting one or more variants of mitochondrial chromosomes at least partially based on one or more genetic characteristics of the one or more variants comprises:

selecting the one or more mitochondrial chromosome variants at least partially based on one or more genetic characteristics of one or more male germ line cells.

24. The method of claim 23, wherein the one or more genetic characteristics of the one or more male germ line cells include one or more genetic characteristics of one or more mitochondrial chromosome variants of the one or more male germ line cells.

25. The method of claim 23, wherein the one or more male germ line cells are one or more stem cells.

26. The method of claim 23, wherein the one or more male germ line cells are one or more haploid germ cells.

27. The method of claim 23, wherein the one or more male germ line cells are one or more spermatozoa.

28. The method of claim 23, further comprising:

providing the one or more male germ line cells to the one or more female germ line cells for fertilization.

29. A method of optimizing one or more oocytes comprising:

selecting one or more variants of mitochondrial chromosomes at least partially based on one or more genetic characteristics of the variants;

providing one or more of the selected mitochondrial chromosome variants to the one or more oocytes.

30. The method of claim 29, further comprising:

obtaining the one or more mitochondrial chromosome variants.

31. A method of treating or preventing one or more genetic disease comprising:

selecting one or more variants of mitochondrial chromosome at least partially based on one or more genetic characteristics of the variants;

wherein one or more unselected mitochondrial chromosome variants have been associated with the one or more genetic diseases; and

providing the one or more selected mitochondrial chromosome variants to one or more oocytes.

32. A method of treating or preventing one or more genetic disease comprising:

selecting one or more variants of mitochondrial chromosome at least partially based on one or more genetic characteristics of the variants;

wherein a combination of one or more nuclear genomes and one or more unselected mitochondrial chromosome variants have been associated with the one or more genetic diseases; and

providing the one or more selected mitochondrial chromosome variants to one or more oocytes.

33. A composition of matter comprising:

one or more optimized germ cells, the optimized germ cells having one or more variants of one or more mitochondrial chromosomes selected based on one or more genetic characteristics of the one or more variants.