COMPOSITIONS AND METHODS FOR TREATMENT OF EAR CANAL INFECTION AND INFLAMMATION

• US 20090111780A1
• Filed: 10/31/2007
• Published: 04/30/2009
• Est. Priority Date: 10/31/2007
• Status: Abandoned Application

• Current Assignee: Everett Laboratories Incorporated (Chemo Iberica, S.A.)
• Original Assignee: Everett Laboratories Incorporated (Chemo Iberica, S.A.)
• Inventors: Giordano, John A
• Application Number:
  US11/932,191
• Publication Number:
  US 20090111780A1
• Time in Patent Office: Days
• US Class Current: 514/171
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/055 the aromatic ring being substituted by halogen
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

The present invention relates to compositions and methods for treatment of ear infections and inflammation. Specifically, the method involves administering to a patient a composition containing an antibacterial, an anti-inflammatory, and an anti-septic that is substantially free of pramoxine to treat the occurrence or negative effects of otic infection and inflammation.

Claims

1. A composition comprising an antibacterial, an anti-inflammatory, and an anti-septic, wherein said composition is substantially free of pramoxine and said composition is for otic use.

2. The composition of claim 1, wherein said composition is substantially free of an anesthetic.

3. The composition of claim 1, wherein said antibacterial is selected from one or more of the group consisting of chloroxylenol (parachlorometaxylenol), acedapsone;

acetosulfone sodium;

alamecin;

alexidine;

amdinocillin;

amdinocillin pivoxil;

amicycline;

amifloxacin;

amifloxacin mesylate;

amikacin;

amikacin sulfate;

aminosalicylic acid;

aminosalicylate sodium;

amoxicillin;

amphomycin;

ampicillin;

ampicillin sodium;

apalcillin sodium;

apramycin;

aspartocin;

astromicin sulfate;

avilamycin;

avoparcin;

azithromycin;

azlocillin;

azlocillin sodium;

bacampicillin hydrochloride;

bacitracin;

bacitracin methylene disalicylate;

bacitracin zinc;

bambermycins;

benzoylpas calcium;

berythromycin;

betamicin sulfate;

biapenem;

biniramycin;

biphenamine hydrochloride;

bispyrithione magsulfex;

butikacin;

butirosin sulfate;

capreomycin sulfate;

carbadox;

carbenicillin disodium;

carbenicillin indanyl sodium;

carbenicillin phenyl sodium;

carbenicillin potassium;

carumonam sodium;

cefaclor;

cefadroxil;

cefamandole;

cefamandole nafate;

cefamandole sodium;

cefaparole;

cefatrizine;

cefazaflur sodium;

cefazolin;

cefazolin sodium;

cefbuperazone;

cefdinir;

cefepime;

cefepime hydrochloride;

cefetecol;

cefixime;

cefmenoxime hydrochloride;

cefmetazole;

cefmetazole sodium;

cefonicid monosodium;

cefonicid sodium;

cefoperazone sodium;

ceforanide;

cefotaxime sodium;

cefotetan;

cefotetan disodium;

cefotiam hydrochloride;

cefoxitin;

cefoxitin sodium;

cefpimizole;

cefpimizole sodium;

cefpiramide;

cefpiramide sodium;

cefpirome sulfate;

cefpodoxime proxetil;

cefprozil;

cefroxadine;

cefsulodin sodium;

ceftazidime;

ceftibuten;

ceftizoxime sodium;

ceftriaxone sodium;

cefuroxime;

cefuroxime axetil;

cefuroxime pivoxetil;

cefuroxime sodium;

cephacetrile sodium;

cephalexin;

cephalexin hydrochloride;

cephaloglycin;

cephaloridine;

cephalothin sodium;

cephapirin sodium;

cephradine;

cetocycline hydrochloride;

cetophenicol;

chloramphenicol;

chloramphenicol palmitate;

chloramphenicol pantothenate complex;

chloramphenicol sodium succinate;

chlorhexidine phosphanilate;

chlortetracycline bisulfate;

chlortetracycline hydrochloride;

cinoxacin;

ciprofloxacin;

ciprofloxacin hydrochloride;

cirolemycin;

clarithromycin;

clinafloxacin hydrochloride;

clindamycin;

clindamycin hydrochloride;

clindamycin palmitate hydrochloride;

clindamycin phosphate;

clofazimine;

cloxacillin benzathine;

cloxacillin sodium;

cloxyquin;

colistimethate sodium;

colistin sulfate;

coumermycin;

coumermycin sodium;

cyclacillin;

cycloserine;

dalfopristin;

dapsone;

daptomycin;

demeclocycline;

demeclocycline hydrochloride;

demecycline;

denofungin;

diaveridine;

dicloxacillin;

dicloxacillin sodium;

dihydrostreptomycin sulfate;

dipyrithione;

dirithromycin;

doxycycline;

doxycycline calcium;

doxycycline fosfatex;

doxycycline hyclate;

droxacin sodium;

enoxacin;

epicillin;

epitetracycline hydrochloride;

erythromycin;

erythromycin acistrate;

erythromycin estolate;

erythromycin ethylsuccinate;

erythromycin gluceptate;

erythromycin lactobionate;

erythromycin propionate;

erythromycin stearate;

ethambutol hydrochloride;

ethionamide;

fleroxacin;

floxacillin;

fludalanine;

flumequine;

fosfomycin;

fosfomycin tromethamine;

fumoxicillin;

furazolium chloride;

furazolium tartrate;

fusidate sodium;

fusidic acid;

ganciclovir and ganciclovir sodium;

gentamicin sulfate;

gloximonam;

gramicidin;

haloprogin;

hetacillin;

hetacillin potassium;

hexedine;

ibafloxacin;

imipenem;

isoconazole;

isepamicin;

isoniazid;

josamycin;

kanamycin sulfate;

kitasamycin;

levofuraltadone;

levopropylcillin potassium;

lexithromycin;

lincomycin;

lincomycin hydrochloride;

lomefloxacin;

lomefloxacin hydrochloride;

lomefloxacin mesylate;

loracarbef;

mafenide;

meclocycline;

meclocycline sulfosalicylate;

megalomicin potassium phosphate;

mequidox;

meropenem;

methacycline;

methacycline hydrochloride;

methenamine;

methenamine hippurate;

methenamine mandelate;

methicillin sodium;

metioprim;

metronidazole hydrochloride;

metronidazole phosphate;

mezlocillin;

mezlocillin sodium;

minocycline;

minocycline hydrochloride;

mirincamycin hydrochloride;

monensin;

monensin sodiumr;

nafcillin sodium;

nalidixate sodium;

nalidixic acid;

natainycin;

nebramycin;

neomycin palmitate;

neomycin sulfate;

neomycin undecylenate;

netilmicin sulfate;

neutramycin;

nifuiradene;

nifuraldezone;

nifuratel;

nifuratrone;

nifurdazil;

nifurimide;

nifiupirinol;

nifurquinazol;

nifurthiazole;

nitrocycline;

nitrofurantoin;

nitromide;

norfloxacin;

novobiocin sodium;

ofloxacin;

onnetoprim;

oxacillin and oxacillin sodium;

oximonam;

oximonam sodium;

oxolinic acid;

oxytetracycline;

oxytetracycline calcium;

oxytetracycline hydrochloride;

paldimycin;

parachlorophenol;

paulomycin;

pefloxacin;

pefloxacin mesylate;

penamecillin;

penicillins such as penicillin g benzathine, penicillin g potassium, penicillin g procaine, penicillin g sodium, penicillin v, penicillin v benzathine, penicillin v hydrabamine, and penicillin v potassium;

pentizidone sodium;

phenyl aminosalicylate;

piperacillin sodium;

pirbenicillin sodium;

piridicillin sodium;

pirlimycin hydrochloride;

pivampicillin hydrochloride;

pivampicillin pamoate;

pivampicillin probenate;

polymyxin b sulfate;

porfiromycin;

propikacin;

pyrazinamide;

pyrithione zinc;

quindecamine acetate;

quinupristin;

racephenicol;

ramoplanin;

ranimycin;

relomycin;

repromicin;

rifabutin;

rifametane;

rifamexil;

rifamide;

rifampin;

rifapentine;

rifaximin;

rolitetracycline;

rolitetracycline nitrate;

rosaramicin;

rosaramicin butyrate;

rosaramicin propionate;

rosaramicin sodium phosphate;

rosaramicin stearate;

rosoxacin;

roxarsone;

roxithromycin;

sancycline;

sanfetrinem sodium;

sarmoxicillin;

sarpicillin;

scopafungin;

sisomicin;

sisomicin sulfate;

sparfloxacin;

spectinomycin hydrochloride;

spiramycin;

stallimycin hydrochloride;

steffimycin;

streptomycin sulfate;

streptonicozid;

sulfabenz;

sulfabenzamide;

sulfacetamide;

sulfacetamide sodium;

sulfacytine;

sulfadiazine;

sulfadiazine sodium;

sulfadoxine;

sulfalene;

sulfamerazine;

sulfameter;

sulfamethazine;

sulfamethizole;

sulfamethoxazole;

sulfamonomethoxine;

sulfamoxole;

sulfanilate zinc;

sulfanitran;

sulfasalazine;

sulfasomizole;

sulfathiazole;

sulfazamet;

sulfisoxazole;

sulfisoxazole acetyl;

sulfisboxazole diolamine;

sulfomyxin;

sulopenem;

sultamricillin;

suncillin sodium;

talampicillin hydrochloride;

teicoplanin;

temafloxacin hydrochloride;

temocillin;

tetracycline;

tetracycline hydrochloride;

tetracycline phosphate complex;

tetroxoprim;

thiamphenicol;

thiphencillin potassium;

ticarcillin cresyl sodium;

ticarcillin disodium;

ticarcillin monosodium;

ticlatone;

tiodonium chloride;

tobramycin;

tobramycin sulfate;

tosufloxacin;

trimethoprim;

trimethoprim sulfate;

trisulfapyrimidines;

troleandomycin;

trospectomycin sulfate;

tyrothricin;

vancomycin;

vancomycin hydrochloride;

virginiamycin and zorbamycin;

4. The composition of claim 1, wherein said anti-inflammatory is selected from one or more of the group consisting of hydrocortisone, hydroxyltriamcinolone alphamethyl dexamethasone, dexamethasone-phosphate, beclomethasone dipropionate, clobetasol valerate, desonide, desoxymethasone, desoxycorticosterone acetate, dexamethasone, dichlorisone, diflorasone diacetate, diflucortolone valerate, fluadrenolone, fluclarolone acetonide, fludrocortisone, flumethasone pivalate, fluosinolone acetonide, fluocinonide, flucortine butylester, fluocortolone, fluprednidene (fluprednylidene)acetate, flurandrenolone, halcinonide, hydrocortisone acetate, hydrocortisone butyrate, methylprednisolone, triamcinolone acetonide, cortisone, cortodoxone, flucetonide, fludrocortisone, difluorosone diacetate, fluradrenalone acetonide, medrysone, amc, amcinafide, betamethasone and the balance of its esters, chlorprednisone, chlorprednisone acetate, clocortelone, clescinolone, dichlorisone, difluprednate, flucloronide, flunisolide, fluoromethalone, fluperolone, fluprednisolone, hydrocortisone valerate, hydrocortisone cyclopentylproprionate, hydrocortamate, meprednisone, paramethasone, prednisolone, prednisone, beclomethasone dipropionate, betamethasone dipropionate, triamcinolone prostaglandin H synthetase inhibitors (Cox I or Cox II), flurbiprofen, ketorolac, suprofen, nepafenac, amfenac, indomethacin, naproxen, ibuprofen, bromfenac, ketoprofen, meclofenamate, piroxicam, sulindac, mefanamic acid, diflusinal, oxaprozin, tolmetin, fenoprofen, benoxaprofen, nabumetome, etodolac, phenylbutazone, aspirin, oxyphenbutazone, NCX-4016, HCT-1026, NCX-284, NCX-456, tenoxicam, carprofen, cyclooxygenase type II selective inhibitors, vioxx, celecoxib, P54, etodolac, L-804600, S-33516;

PAF antagonists, A-137491, ABT-299, apafant, bepafant, minopafant, E-6123, BN-50727, nupafant, modipafant, PDE IV inhibitors, ariflo, torbafylline, rolipram, filaminast, piclamilast, cipamfylline, CG-1088, V-11294A, CT-2820, PD-168787, CP-293121, DWP-205297, CP-220629, SH-636, BAY-19-8004, and roflumilast.

5. The composition of claim 1, wherein said anti-septic is selected from one or more of the group consisting of benzalkonium chloride, cetyl trimethylammonium bromide, cetylpyridinium chloride, cetylpyridinium chloride, benzethonium chloride, 2% aqueous iodine, boric acid, chlorhexidine gluconate, hydrogen peroxide, octenidine dihydrochloride, ethanol, isopropanol, n-propanol, phenylethyl alcohol, benzyl alcohol, and phenoxyethyl alcohol.

6. The composition of claim 1, wherein said antibacterial is chloroxylenol, said anti-inflammatory is hydrocortisone and said anti-septic is benzalkonium chloride, and wherein said composition is administrable to a patient.

7. The composition of claim 6, wherein said composition is in range amounts per 1 ml of solution.

15. The composition of claim 7, wherein said chloroxylenol is present in the range of about 1.5 mg to about 0.5 mg.

16. The composition of claim 7, wherein said hydrocortisone is present in the range of about 15 mg to about 5 mg.

17. The composition of claim 7, wherein said benzalkonium chloride is present in the range of about 0.15 mg to about 0.05 mg.

18. The composition of claim 7, wherein said chloroxylenol is present in the range of about 1.25 mg to about 0.75 mg.

19. The composition of claim 7, wherein said hydrocortisone is present in the range of about 12.5 mg to about 7.5 mg.

20. The composition of claim 7, wherein said benzalkonium chloride is present in the range of about 0.125 mg to about 0.075 mg.

21. The composition of claim 7, wherein said chloroxylenol is present in the range of about 1.1 mg to about 0.9 mg.

22. The composition of claim 7, wherein said hydrocortisone is present in the range of about 11 mg to about 9 mg.

23. The composition of claim 7, wherein said benzalkonium chloride is present in the range of about 0.11 mg to about 0.09 mg.

24. The composition of claim 7, wherein said composition comprises about 1.25 mg to about 0.75 mg of chloroxylenol;

about 12.5 mg to about 7.5 mg of hydrocortisone;

about 0.125 mg to about 0.075 mg of benzalkonium chloride.

25. The composition of claim 7, wherein said composition comprises about 1.5 mg to about 0.5 mg of chloroxylenol;

about 15 mg to about 5 mg of hydrocortisone;

about 0.15 mg to about 0.05 mg of benzalkonium chloride.

26. The composition of claim 7, wherein said composition comprises about 1.1 mg to about 0.9 mg of chloroxylenol;

about 11 mg to about 9 mg of hydrocortisone;

about 0.11 mg to about 0.09 mg of benzalkonium chloride.

27. The composition of claim 7, wherein said chloroxylenol is present in the amount of about 1 mg.

28. The composition of claim 7, wherein said hydrocortisone is present in the amount of about 10 mg.

29. The composition of claim 7, wherein said benzalkonium chloride is present in the amount of about 0.1 mg.

30. The composition of claim 7, wherein said chloroxylenol is present in the amount of about 1 mg;

said hydrocortisone is present in the amount of about 10 mg; and

said benzalkonium chloride is present in the amount of about 0.1 mg.

31. The composition of claim 1, wherein said composition is formulated within a vehicle.

32. The composition of claim 31, wherein said vehicle is aqueous, non-aqueous, oleaginous and viscous.

33. The composition of claim 31, wherein said vehicle is selected from one or more of the group consisting of glycols, alcohols, ethanol, isopropanol, glycerol, sorbitol, 2-methoxy ethanol, mannitol, diethyl ether, dipropyl ether, methoxy polyoxyethylenes, polyoxyethylene glycerols, polyoxyethylene sorbitols, stearoyl diacetin glycerin, dehydrated glycerin, mineral oil, water, anhydrous glycerin, glycerol polyvinyl alcohol, polyvinyl pyrrolidone, methyl cellulose, hydroxy propyl methylcellulose, hydroxyethyl cellulose, carboxymethyl cellulose, hydroxy propyl cellulose sorbitol, xylitol, cetrimide alkylaryltrialkylammonium chloride, alkylaryltrimethylammonium chloride, amantanium bromide, benzethonium chloride, benzododecinium bromide, cetalkonium chloride, cethexonium bromide, cetrimonium bromine, and cetyldimethylethylammonium bromide.

34. The composition of claim 33, wherein said glycol is selected from one or more of the group consisting of polyethylene glycol (PEG) 300 or any other molecular weight of PEG, propylene glycol, propylene glycol diacetate, diethylene glycol, ethylene glycol, hexalene glycol and hexenyl glycol.

35. The composition of claim 34, wherein said propylene glycol is present in the concentration range of about 2 percent to 4 percent.

36. The composition of claim 34, wherein said propylene glycol is present in the concentration of about 3 percent.

37. The composition of claim 1, wherein said composition comprises a skin permeation enhancer.

38. The composition of claim 37, wherein said skin permeation enhancer is selected from one or more of the group consisting of ethanol, isopropanol, n-alkanols, limonene, terpenes, dioxolane, propylene glycol, ethylene glycol, glycerol, dimethylsulfoxide (DMSO), dimethylformamide, methyl dodecyl sulfoxide, dimethylacetamide, isopropyl myristate/palmitate, ethyl acetate, butyl acetate, methyl proprionate, capric/caprylic triglycerides;

ketones, acetamides, triolein;

sodium lauryl sulfate, alkanoic acids, caprylic acid, azone, oleyl alcohol and dialkylamino acetates.

39. The composition of claim 1, wherein said composition is administered to said patient to treat and/or alleviate the occurrence or negative effects of otic inflammation.

40. The composition of claim 1, wherein said composition is administered to said patient to treat and/or alleviate the occurrence or negative effects of otic infections.

41. The composition of claim 1, wherein said composition is administered to said patient to treat and/or alleviate the occurrence or negative effects of otitis externa.

42. The composition of claim 41, wherein said otitis externa is from one or more of the group consisting of acute otitis externa, chronic otitis externa.

43. The composition of claim 40, wherein said otic infections is from one or more of the group consisting of furunculosis, otomycosis, acute diffuse otitiss externa, acute localised otitis externa, chronic otitis externa, herpes oticus, dermatoses, malignant otitis externa, perichondritis, acute otitis media, serous otitis media, chronic otitis media, and vestibular neruonitis.

44. The composition of claim 1, wherein said composition is contained within a delivery system comprising a solution in a container that permits the administration of drops.

45. A method comprising administering to a patient the composition of claim 1.

46. A method comprising a patient taking the composition of claim 1.

47. The method of claim 45, wherein said composition is substantially free of an anesthetic.

48. The method of claim 45, wherein said antibacterial is selected from one or more of the group consisting of chloroxylenol (parachlorometaxylenol), acedapsone;

acetosulfone sodium;

alamecin;

alexidine;

amdinocillin;

amdinocillin pivoxil;

amicycline;

amifloxacin;

amifloxacin mesylate;

amikacin;

amikacin sulfate;

aminosalicylic acid;

aminosalicylate sodium;

amoxicillin;

amphomycin;

ampicillin;

ampicillin sodium;

apalcillin sodium;

apramycin;

aspartocin;

astromicin sulfate;

avilamycin;

avoparcin;

azithromycin;

azlocillin;

azlocillin sodium;

bacampicillin hydrochloride;

bacitracin;

bacitracin methylene disalicylate;

bacitracin zinc;

bambermycins;

benzoylpas calcium;

berythromycin;

betamicin sulfate;

biapenem;

biniramycin;

biphenamine hydrochloride;

bispyrithione magsulfex;

butikacin;

butirosin sulfate;

capreomycin sulfate;

carbadox;

carbenicillin disodium;

carbenicillin indanyl sodium;

carbenicillin phenyl sodium;

carbenicillin potassium;

carumonam sodium;

cefaclor;

cefadroxil;

cefamandole;

cefamandole nafate;

cefamandole sodium;

cefaparole;

cefatrizine;

cefazaflur sodium;

cefazolin;

cefazolin sodium;

cefbuperazone;

cefdinir;

cefepime;

cefepime hydrochloride;

cefetecol;

cefixime;

cefmenoxime hydrochloride;

cefmetazole;

cefmetazole sodium;

cefonicid monosodium;

cefonicid sodium;

cefoperazone sodium;

ceforanide;

cefotaxime sodium;

cefotetan;

cefotetan disodium;

cefotiam hydrochloride;

cefoxitin;

cefoxitin sodium;

cefpimizole;

cefpimizole sodium;

cefpiramide;

cefpiramide sodium;

cefpirome sulfate;

cefpodoxime proxetil;

cefprozil;

cefroxadine;

cefsulodin sodium;

ceftazidime;

ceftibuten;

ceftizoxime sodium;

ceftriaxone sodium;

cefuroxime;

cefuroxime axetil;

cefuroxime pivoxetil;

cefuroxime sodium;

cephacetrile sodium;

cephalexin;

cephalexin hydrochloride;

cephaloglycin;

cephaloridine;

cephalothin sodium;

cephapirin sodium;

cephradine;

cetocycline hydrochloride;

cetophenicol;

chloramphenicol;

chloramphenicol palmitate;

chloramphenicol pantothenafe complex;

chloramphenicol sodium succinate;

chlorhexidine phosphanilate;

chlortetracycline bisulfate;

chlortetracycline hydrochloride;

cinoxacin;

ciprofloxacin;

ciprofloxacin hydrochloride;

cirolemycin;

clarithromycin;

clinafloxacin hydrochloride;

clindamycin;

clindamycin hydrochloride;

clindamycin palmitate hydrochloride;

clindamycin phosphate;

clofazimine;

cloxacillin benzathine;

cloxacillin sodium;

cloxyquin;

colistimethate sodium;

colistin sulfate;

coumermycin;

coumermycin sodium;

cyclacillin;

cycloserine;

dalfopristin;

dapsone;

daptomycin;

demeclocycline;

demeclocycline hydrochloride;

demecycline;

denofungin;

diaveridine;

dicloxacillin;

dicloxacillin sodium;

dihydrostreptomycin sulfate;

dipyrithione;

dirithromycin;

doxycycline;

doxycycline calcium;

doxycycline fosfatex;

doxycycline hyclate;

droxacin sodium;

enoxacin;

epicillin;

epitetracycline hydrochloride;

erythromycin;

erythromycin acistrate;

erythromycin estolate;

erythromycin ethylsuccinate;

erythromycin gluceptate;

erythromycin lactobionate;

erythromycin propionate;

erythromycin stearate;

ethambutol hydrochloride;

ethionamide;

fleroxacin;

floxacillin;

fludalanine;

flumequine;

fosfomycin;

fosfomycin tromethamine;

fumoxicillin;

furazolium chloride;

furazolium tartrate;

fusidate sodium;

fusidic acid;

ganciclovir and ganciclovir sodium;

gentamicin sulfate;

gloximonam;

gramicidin;

haloprogin;

hetacillin;

hetacillin potassium;

hexedine;

ibafloxacin;

imipenem;

isoconazole;

isepamicin;

isoniazid;

josamycin;

kanamycin sulfate;

kitasamycin;

levofuraltadone;

levopropylcillin potassium;

lexithromycin;

lincomycin;

lincomycin hydrochloride;

lomefloxacin;

lomefloxacin hydrochloride;

lomefloxacin mesylate;

loracarbef;

mafenide;

meclocycline;

meclocycline sulfosalicylate;

megalomicin potassium phosphate;

mequidox;

meropenem;

methacycline;

methacycline hydrochloride;

methenamine;

methenamine hippurate;

methenamine mandelate;

methicillin sodium;

metioprim;

metronidazole hydrochloride;

metronidazole phosphate;

mezlocillin;

mezlocillin sodium;

minocycline;

minocycline hydrochloride;

mirincamycin hydrochloride;

monensin;

monensin sodiumr;

nafcillin sodium;

nalidixate sodium;

nalidixic acid;

natainycin;

nebramycin;

neomycin palmitate;

neomycin sulfate;

neomycin undecylenate;

netilmicin sulfate;

neutramycin;

nifuiradene;

nifuraldezone;

nifuratel;

nifuratrone;

nifurdazil;

nifurimide;

nifiupirinol;

nifurquinazol;

nifurthiazole;

nitrocycline;

nitrofurantoin;

nitromide;

norfloxacin;

novobiocin sodium;

ofloxacin;

onnetoprim;

oxacillin and oxacillin sodium;

oximonam;

oximonam sodium;

oxolinic acid;

oxytetracycline;

oxytetracycline calcium;

oxytetracycline hydrochloride;

paldimycin;

parachlorophenol;

paulomycin;

pefloxacin;

pefloxacin mesylate;

penamecillin;

penicillins such as penicillin g benzathine, penicillin g potassium, penicillin g procaine, penicillin g sodium, penicillin v, penicillin v benzathine, penicillin v hydrabamine, and penicillin v potassium;

pentizidone sodium;

phenyl aminosalicylate;

piperacillin sodium;

pirbenicillin sodium;

piridicillin sodium;

pirlimycin hydrochloride;

pivampicillin hydrochloride;

pivampicillin pamoate;

pivampicillin probenate;

polymyxin b sulfate;

porfiromycin;

propikacin;

pyrazinamide;

pyrithione zinc;

quindecamine acetate;

quinupristin;

racephenicol;

ramoplanin;

ranimycin;

relomycin;

repromicin;

rifabutin;

rifametane;

rifamexil;

rifamide;

rifampin;

rifapentine;

rifaximin;

rolitetracycline;

rolitetracycline nitrate;

rosaramicin;

rosaramicin butyrate;

rosaramicin propionate;

rosaramicin sodium phosphate;

rosaramicin stearate;

rosoxacin;

roxarsone;

roxithromycin;

sancycline;

sanfetrinem sodium;

sarmoxicillin;

sarpicillin;

scopafungin;

sisomicin;

sisomicin sulfate;

sparfloxacin;

spectinomycin hydrochloride;

spiramycin;

stallimycin hydrochloride;

steffimycin;

streptomycin sulfate;

streptonicozid;

sulfabenz;

sulfabenzamide;

sulfacetamide;

sulfacetamide sodium;

sulfacytine;

sulfadiazine;

sulfadiazine sodium;

sulfadoxine;

sulfalene;

sulfamerazine;

sulfameter;

sulfamethazine;

sulfamethizole;

sulfamethoxazole;

sulfamonomethoxine;

sulfamoxole;

sulfanilate zinc;

sulfanitran;

sulfasalazine;

sulfasomizole;

sulfathiazole;

sulfazamet;

sulfisoxazole;

sulfisoxazole acetyl;

sulfisboxazole diolamine;

sulfomyxin;

sulopenem;

sultamricillin;

suncillin sodium;

talampicillin hydrochloride;

teicoplanin;

temafloxacin hydrochloride;

temocillin;

tetracycline;

tetracycline hydrochloride;

tetracycline phosphate complex;

tetroxoprim;

thiamphenicol;

thiphencillin potassium;

ticarcillin cresyl sodium;

ticarcillin disodium;

ticarcillin monosodium;

ticlatone;

tiodonium chloride;

tobramycin;

tobramycin sulfate;

tosufloxacin;

trimethoprim;

trimethoprim sulfate;

trisulfapyrimidines;

troleandomycin;

trospectomycin sulfate;

tyrothricin;

vancomycin;

vancomycin hydrochloride;

virginiamycin and zorbamycin.

49. The method of claim 45, wherein said anti-inflammatory is selected from one or more of the group consisting hydrocortisone, hydroxyltriamcinolone alphamethyl dexamethasone, dexamethasone-phosphate, beclomethasone dipropionate, clobetasol valerate, desonide, desoxymethasone, desoxycorticosterone acetate, dexamethasone, dichlorisone, diflorasone diacetate, diflucortolone valerate, fluadrenolone, fluclarolone acetonide, fludrocortisone, flumethasone pivalate, fluosinolone acetonide, fluocinonide, flucortine butylester, fluocortolone, fluprednidene (fluprednylidene)acetate, flurandrenolone, halcinonide, hydrocortisone acetate, hydrocortisone butyrate, methylprednisolone, triamcinolone acetonide, cortisone, cortodoxone, flucetonide, fludrocortisone, difluorosone diacetate, fluradrenalone acetonide, medrysone, amc, amcinafide, betamethasone and the balance of its esters, chlorprednisone, chlorprednisone acetate, clocortelone, clescinolone, dichlorisone, difluprednate, flucloronide, flunisolide, fluoromethalone, fluperolone, fluprednisolone, hydrocortisone valerate, hydrocortisone cyclopentylproprionate, hydrocortamate, meprednisone, paramethasone, prednisolone, prednisone, beclomethasone dipropionate, betamethasone dipropionate, triamcinolone prostaglandin H synthetase inhibitors (Cox I or Cox II), flurbiprofen, ketorolac, suprofen, nepafenac, amfenac, indomethacin, naproxen, ibuprofen, bromfenac, ketoprofen, meclofenamate, piroxicam, sulindac, mefanamic acid, diflusinal, oxaprozin, tolmetin, fenoprofen, benoxaprofen, nabumetome, etodolac, phenylbutazone, aspirin, oxyphenbutazone, NCX-4016, HCT-1026, NCX-284, NCX-456, tenoxicam and carprofen, cyclooxygenase type II selective inhibitors, vioxx, celecoxib, P54, etodolac, L-804600, S-33516;

PAF antagonists, A-137491, ABT-299, apafant, bepafant, minopafant, E-6123, BN-50727, nupafant and modipafant, PDE IV inhibitors, ariflo, torbafylline, rolipram, filaminast, piclamilast, cipamfylline, CG-1088, V-11294A, CT-2820, PD-168787, CP-293121, DWP-205297, CP-220629, SH-636, BAY-19-8004, and roflumilast.

50. The method of claim 45, wherein said anti-septic is selected from one or more of the group consisting of benzalkonium chloride, cetyl trimethylammonium bromide, cetylpyridinium chloride, cetylpyridinium chloride, benzethonium chloride, 2% aqueous iodine, boric acid, chlorhexidine gluconate, hydrogen peroxide, octenidine dihydrochloride, ethanol, isopropanol, n-propanol, phenylethyl alcohol, benzyl alcohol, and phenoxyethyl alcohol.

51. The method of claim 45, wherein said antibacterial is chloroxylenol, said anti-inflammatory is hydrocortisone and said anti-septic is benzalkonium, and wherein said composition is administrable to a patient.

52. The method of claim 51, wherein said composition is in range amounts per 1 ml of solution.

53. The method of claim 45, wherein said composition is substantially free of other added active ingredients.

54. The method of claim 53, wherein said other active ingredient is another antibacterial.

55. The method of claim 53, wherein said other active ingredient is another anti-inflammatory.

56. The method of claim 53, wherein said other active ingredient is another anti-septic.

57. The method of claim 54, wherein said antibacterial is selected from one or more of the group consisting of acedapsone;

acetosulfone sodium;

alamecin;

alexidine;

amdinocillin;

amdinocillin pivoxil;

amicycline;

amifloxacin;

amifloxacin mesylate;

amikacin;

amikacin sulfate;

aminosalicylic acid;

aminosalicylate sodium;

amoxicillin;

amphomycin;

ampicillin;

ampicillin sodium;

apalcillin sodium;

apramycin;

aspartocin;

astromicin sulfate;

avilamycin;

avoparcin;

azithromycin;

azlocillin;

azlocillin sodium;

bacampicillin hydrochloride;

bacitracin;

bacitracin methylene disalicylate;

bacitracin zinc;

bambermycins;

benzoylpas calcium;

berythromycin;

betamicin sulfate;

biapenem;

biniramycin;

biphenamine hydrochloride;

bispyrithione magsulfex;

butikacin;

butirosin sulfate;

capreomycin sulfate;

carbadox;

carbenicillin disodium;

carbenicillin indanyl sodium;

carbenicillin phenyl sodium;

carbenicillin potassium;

carumonam sodium;

cefaclor;

cefadroxil;

cefamandole;

cefamandole nafate;

cefamandole sodium;

cefaparole;

cefatrizine;

cefazaflur sodium;

cefazolin;

cefazolin sodium;

cefbuperazone;

cefdinir;

cefepime;

cefepime hydrochloride;

cefetecol;

cefixime;

cefmenoxime hydrochloride;

cefmetazole;

cefmetazole sodium;

cefonicid monosodium;

cefonicid sodium;

cefoperazone sodium;

ceforanide;

cefotaxime sodium;

cefotetan;

cefotetan disodium;

cefotiam hydrochloride;

cefoxitin;

cefoxitin sodium;

cefpimizole;

cefpimizole sodium;

cefpiramide;

cefpiramide sodium;

cefpirome sulfate;

cefpodoxime proxetil;

cefprozil;

cefroxadine;

cefsulodin sodium;

ceftazidime;

ceftibuten;

ceftizoxime sodium;

ceftriaxone sodium;

cefuroxime;

cefuroxime axetil;

cefuroxime pivoxetil;

cefuroxime sodium;

cephacetrile sodium;

cephalexin;

cephalexin hydrochloride;

cephaloglycin;

cephaloridine;

cephalothin sodium;

cephapirin sodium;

cephradine;

cetocycline hydrochloride;

cetophenicol;

chloramphenicol;

chloramphenicol palmitate;

chloramphenicol pantothenate complex;

chloramphenicol sodium succinate;

chlorhexidine phosphanilate;

chlortetracycline bisulfate;

chlortetracycline hydrochloride;

cinoxacin;

ciprofloxacin;

ciprofloxacin hydrochloride;

cirolemycin;

clarithromycin;

clinafloxacin hydrochloride;

clindamycin;

clindamycin hydrochloride;

clindamycin palmitate hydrochloride;

clindamycin phosphate;

clofazimine;

cloxacillin benzathine;

cloxacillin sodium;

cloxyquin;

colistimethate sodium;

colistin sulfate;

coumermycin;

coumermycin sodium;

cyclacillin;

cycloserine;

dalfopristin;

dapsone;

daptomycin;

demeclocycline;

demeclocycline hydrochloride;

demecycline;

denofungin;

diaveridine;

dicloxacillin;

dicloxacillin sodium;

dihydrostreptomycin sulfate;

dipyrithione;

dirithromycin;

doxycycline;

doxycycline calcium;

doxycycline fosfatex;

doxycycline hyclate;

droxacin sodium;

enoxacin;

epicillin;

epitetracycline hydrochloride;

erythromycin;

erythromycin acistrate;

erythromycin estolate;

erythromycin ethylsuccinate;

erythromycin gluceptate;

erythromycin lactobionate;

erythromycin propionate;

erythromycin stearate;

ethambutol hydrochloride;

ethionamide;

fleroxacin;

floxacillin;

fludalanine;

flumequine;

fosfomycin;

fosfomycin tromethamine;

fumoxicillin;

furazolium chloride;

furazolium tartrate;

fusidate sodium;

fusidic acid;

ganciclovir and ganciclovir sodium;

gentamicin sulfate;

gloximonam;

gramicidin;

haloprogin;

hetacillin;

hetacillin potassium;

hexedine;

ibafloxacin;

imipenem;

isoconazole;

isepamicin;

isoniazid;

josamycin;

kanamycin sulfate;

kitasamycin;

levofuraltadone;

levopropylcillin potassium;

lexithromycin;

lincomycin;

lincomycin hydrochloride;

lomefloxacin;

lomefloxacin hydrochloride;

lomefloxacin mesylate;

loracarbef;

mafenide;

meclocycline;

meclocycline sulfosalicylate;

megalomicin potassium phosphate;

mequidox;

meropenem;

methacycline;

methacycline hydrochloride;

methenamine;

methenamine hippurate;

methenamine mandelate;

methicillin sodium;

metioprim;

metronidazole hydrochloride;

metronidazole phosphate;

mezlocillin;

mezlocillin sodium;

minocycline;

minocycline hydrochloride;

mirincamycin hydrochloride;

monensin;

monensin sodiumr;

nafcillin sodium;

nalidixate sodium;

nalidixic acid;

natainycin;

nebramycin;

neomycin palmitate;

neomycin sulfate;

neomycin undecylenate;

netilmicin sulfate;

neutramycin;

nifuiradene;

nifuraldezone;

nifuratel;

nifuratrone;

nifurdazil;

nifurimide;

nifiupirinol;

nifurquinazol;

nifurthiazole;

nitrocycline;

nitrofurantoin;

nitromide;

norfloxacin;

novobiocin sodium;

ofloxacin;

onnetoprim;

oxacillin and oxacillin sodium;

oximonam;

oximonam sodium;

oxolinic acid;

oxytetracycline;

oxytetracycline calcium;

oxytetracycline hydrochloride;

paldimycin;

parachlorophenol;

paulomycin;

pefloxacin;

pefloxacin mesylate;

penamecillin;

penicillins such as penicillin g benzathine, penicillin g potassium, penicillin g procaine, penicillin g sodium, penicillin v, penicillin v benzathine, penicillin v hydrabamine, and penicillin v potassium;

pentizidone sodium;

phenyl aminosalicylate;

piperacillin sodium;

pirbenicillin sodium;

piridicillin sodium;

pirlimycin hydrochloride;

pivampicillin hydrochloride;

pivampicillin pamoate;

pivampicillin probenate;

polymyxin b sulfate;

porfiromycin;

propikacin;

pyrazinamide;

pyrithione zinc;

quindecamine acetate;

quinupristin;

racephenicol;

ramoplanin;

ranimycin;

relomycin;

repromicin;

rifabutin;

rifametane;

rifamexil;

rifamide;

rifampin;

rifapentine;

rifaximin;

rolitetracycline;

rolitetracycline nitrate;

rosaramicin;

rosaramicin butyrate;

rosaramicin propionate;

rosaramicin sodium phosphate;

rosaramicin stearate;

rosoxacin;

roxarsone;

roxithromycin;

sancycline;

sanfetrinem sodium;

sarmoxicillin;

sarpicillin;

scopafungin;

sisomicin;

sisomicin sulfate;

sparfloxacin;

spectinomycin hydrochloride;

spiramycin;

stallimycin hydrochloride;

steffimycin;

streptomycin sulfate;

streptonicozid;

sulfabenz;

sulfabenzamide;

sulfacetamide;

sulfacetamide sodium;

sulfacytine;

sulfadiazine;

sulfadiazine sodium;

sulfadoxine;

sulfalene;

sulfamerazine;

sulfameter;

sulfamethazine;

sulfamethizole;

sulfamethoxazole;

sulfamonomethoxine;

sulfamoxole;

sulfanilate zinc;

sulfanitran;

sulfasalazine;

sulfasomizole;

sulfathiazole;

sulfazamet;

sulfisoxazole;

sulfisoxazole acetyl;

sulfisboxazole diolamine;

sulfomyxin;

sulopenem;

sultamricillin;

suncillin sodium;

talampicillin hydrochloride;

teicoplanin;

temafloxacin hydrochloride;

temocillin;

tetracycline;

tetracycline hydrochloride;

tetracycline phosphate complex;

tetroxoprim;

thiamphenicol;

thiphencillin potassium;

ticarcillin cresyl sodium;

ticarcillin disodium;

ticarcillin monosodium;

ticlatone;

tiodonium chloride;

tobramycin;

tobramycin sulfate;

tosufloxacin;

trimethoprim;

trimethoprim sulfate;

trisulfapyrimidines;

troleandomycin;

trospectomycin sulfate;

tyrothricin;

vancomycin;

vancomycin hydrochloride;

virginiamycin and zorbamycin.

58. The method of claim 55, wherein said anti-inflammatory is selected from one or more of the group consisting hydroxyltriamcinolone alphamethyl dexamethasone, dexamethasone-phosphate, beclomethasone dipropionate, clobetasol valerate, desonide, desoxymethasone, desoxycorticosterone acetate, dexamethasone, dichlorisone, diflorasone diacetate, diflucortolone valerate, fluadrenolone, fluclarolone acetonide, fludrocortisone, flumethasone pivalate, fluosinolone acetonide, fluocinonide, flucortine butylester, fluocortolone, fluprednidene (fluprednylidene)acetate, flurandrenolone, halcinonide, hydrocortisone acetate, hydrocortisone butyrate, methylprednisolone, triamcinolone acetonide, cortisone, cortodoxone, flucetonide, fludrocortisone, difluorosone diacetate, fluradrenalone acetonide, medrysone, amc, amcinafide, betamethasone and the balance of its esters, chlorprednisone, chlorprednisone acetate, clocortelone, clescinolone, dichlorisone, difluprednate, flucloronide, flunisolide, fluoromethalone, fluperolone, fluprednisolone, hydrocortisone valerate, hydrocortisone cyclopentylproprionate, hydrocortamate, meprednisone, paramethasone, prednisolone, prednisone, beclomethasone dipropionate, betamethasone dipropionate, triamcinolone prostaglandin H synthetase inhibitors (Cox I or Cox II), flurbiprofen, ketorolac, suprofen, nepafenac, amfenac, indomethacin, naproxen, ibuprofen, bromfenac, ketoprofen, meclofenamate, piroxicam, sulindac, mefanamic acid, diflusinal, oxaprozin, tolmetin, fenoprofen, benoxaprofen, nabumetome, etodolac, phenylbutazone, aspirin, oxyphenbutazone, NCX-4016, HCT-1026, NCX-284, NCX-456, tenoxicam, carprofen, cyclooxygenase type II selective inhibitors, vioxx, celecoxib, P54, etodolac, L-804600, S-33516;

PAF antagonists, A-137491, ABT-299, apafant, bepafant, minopafant, E-6123, BN-50727, nupafant and modipafant, PDE IV inhibitors, ariflo, torbafylline, rolipram, filaminast, piclamilast, cipamfylline, CG-1088, V-11294A, CT-2820, PD-168787, CP-293121, DWP-205297, CP-220629, SH-636, BAY-19-8004, and roflumilast.

59. The method of claim 56, wherein said anti-septic is selected from one or more of the group consisting of cetyl trimethylammonium bromide, cetylpyridinium chloride, cetylpyridinium chloride, benzethonium chloride, 2% aqueous iodine, boric acid, Chlorhexidine Gluconate, Hydrogen peroxide, Octenidine dihydrochloride, ethanol, isopropanol, n-propanol, phenylethyl alcohol, benzyl alcohol, and phenoxyethyl alcohol.

60. The method of claim 51, wherein said chloroxylenol is present in the range of about 1.5 to about 0.5 mg.

61. The method of claim 51, wherein said hydrocortisone is present in the range of about 15 mg to about 5 mg.

62. The method of claim 51, wherein said benzalkonium chloride is present in the range of about 0.15 mg to about 0.05 mg.

63. The method of claim 51, wherein said chloroxylenol is present in the range of about 1.25 to about 0.75 mg.

64. The method of claim 51, wherein said hydrocortisone is present in the range of about 12.5 mg to about 7.5 mg.

65. The method of claim 51, wherein said benzalkonium chloride is present in the range of about 0.125 mg to about 0.075 mg.

66. The method of claim 51, wherein said chloroxylenol is present in the range of about 1.1 mg to about 0.9 mg.

67. The method of claim 51, wherein said hydrocortisone is present in the range of about 11 mg to about 9 mg.

68. The method of claim 51, wherein said benzalkonium chloride is present in the range of about 0.11 mg to about 0.09 mg.

69. The method of claim 51, wherein said composition comprises about 1.25 mg to about 0.75 mg of chloroxylenol;

about 12.5 mg to about 7.5 mg of hydrocortisone;

about 0.125 mg to about 0.075 mg of benzalkonium chloride.

70. The method of claim 51, wherein said composition comprises about 1.5 mg to about 0.5 mg of chloroxylenol;

about 15 mg to about 5 mg of hydrocortisone;

about 0.15 mg to about 0.05 mg of benzalkonium chloride.

71. The method of claim 51, wherein said composition comprises about 1.1 mg to about 0.9 mg of chloroxylenol;

about 11 mg to about 9 mg of hydrocortisone;

about 0.11 mg to about 0.09 mg of benzalkonium chloride.

72. The method of claim 51, wherein said chloroxylenol is present in the amount of about 1 mg.

73. The method of claim 51, wherein said hydrocortisone is present in the amount of about 10 mg.

74. The method of claim 51, wherein said benzalkonium chloride is present in the amount of about 0.1 mg.

75. The method of claim 45, wherein said antibacterial, anti-inflammatory an anti-septic are formulated into a vehicle.

76. The method of claim 75, wherein said vehicle is aqueous, non-aqueous, oleaginous or viscous.

77. The method of claim 76, wherein said vehicle is selected from one or more of the group consisting of glycols, alcohols, ethanol, isopropanol, glycerol, sorbitol, 2-methoxy ethanol, mannitol, diethyl ether, dipropyl ether, methoxy polyoxyethylenes, polyoxyethylene glycerols, polyoxyethylene sorbitols, stearoyl diacetin glycerin, dehydrated glycerin, mineral oil, water, anhydrous glycerin, glycerol polyvinyl alcohol, polyvinyl pyrrolidone, methyl cellulose, hydroxy propyl methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, hydroxy propyl cellulose sorbitol, xylitol, cetrimide alkylaryltrialkylammonium chloride, alkylaryltrimethylammonium chloride, amantanium bromide, benzethonium chloride, benzododecinium bromide, cetalkonium chloride, cethexonium bromide, cetrimonium bromine, and cetyldimethylethylammonium bromide.

78. The method of claim 77, wherein said glycol is selected from one or more of the group consisting of polyethylene glycol (PEG) 300 or any other molecular weight of PEG, propylene glycol, propylene glycol diacetate, diethylene glycol, ethylene glycol, hexalene glycol and hexenyl glycol.

79. The method of claim 78, wherein said propylene glycol is present in the concentration range of about 2 percent to 4 percent.

80. The method of claim 78, wherein said propylene glycol is present in the concentration of about 3 percent.

81. The method of claim 45, wherein said composition comprises a skin permeation enhancer.

82. The method of claim 81, wherein said skin permeation enhancer is selected from one or more of the group consisting of ethanol, isopropanol, n-alkanols, limonene, terpenes, dioxolane, propylene glycol, ethylene glycol, glycerol, dimethylsulfoxide (DMSO), dimethylformamide, methyl dodecyl sulfoxide, dimethylacetamide, isopropyl myristate/palmitate, ethyl acetate, butyl acetate, methyl proprionate, capric/caprylic triglycerides;

ketones, acetamides, triolein;

sodium lauryl sulfate, alkanoic acids, caprylic acid, azone, oleyl alcohol and dialkylamino acetates.

83. The method of claim 45, wherein said composition is administered to said patient to treat and/or alleviate the occurrence or negative effects of otic inflammation.

84. The method of claim 45, wherein said composition is administered to said patient to treat and/or alleviate the occurrence or negative effects of otic infections.

85. The method of claim 45, wherein said composition is administered to said patient to treat and/or alleviate the occurrence or negative effects of otitis externa.

86. The method of claim 85, wherein said otitis externa is from one or more of the group consisting of acute otitis externa, chronic otitis externa.

87. The method of claim 84, wherein said otic infections is from one or more of the group consisting of furunculosis, otomycosis, acute diffuse otitis externa, acute localised otitis externa, chronic otitis externa, herpes oticus, dermatoses, malignant otitis externa, perichondritis, acute otitis media, serous otitis media, chronic otitis media, and vestibular neruonitis.

88. The method of claim 45, wherein said composition is contained within a delivery system comprising a solution in a container that permits the administration of drops.

89. The method of claim 45, wherein said composition is administered to said patient at a frequency selected from the group consisting of once a day, twice a day, three times a day, four times a day, five times a day, six times a day, seven times a day, eight times a day, nine times a day, ten times a day, eleven times a day and twelve times a day.

90. The method of claim 46, wherein said patient takes said composition at a frequency selected from the group consisting of once a day, twice a day, three times a day, four times a day, five times a day, six times a day, seven times a day, eight times a day, nine times a day, ten times a day, eleven times a day and twelve times a day.

91. The method of claim 45, wherein said composition is administered to said patient at a frequency selected from the group consisting of once every hour, once every two hours, once every three hours, once every four hours, once every five hours, once every six hours, once every seven hours, once every eight hours, once every nine hours, once every ten hours, once every eleven hours, once every twelve hours, once every thirteen hours, once every fourteen hours, once every fifteen hours, once every sixteen hours, once every seventeen hours, once every eighteen hours, once every nineteen hours, once every twenty hours, once every twenty one hours, once every twenty two hours, once every twenty three hours and once every twenty four hours.

92. The method of claim 46, wherein said patient takes said composition at a frequency selected from the group consisting of once every hour, once every two hours, once every three hours, once every four hours, once every five hours, once every six hours, once every seven hours, once every eight hours, once every nine hours, once every ten hours, once every eleven hours, once every twelve hours, once every thirteen hours, once every fourteen hours, once every fifteen hours, once every sixteen hours, once every seventeen hours, once every eighteen hours, once every nineteen hours, once every twenty hours, once every twenty one hours, once every twenty two hours, once every twenty three hours and once every twenty four hours.

93. The method of claim 45, wherein said composition is administered to said patient in a dose selected from the group consisting of 1 drop, 2 drops, 3 drops, 4 drops, 5 drops, 6 drops, 7 drops and 8 drops.

8. The composition of claim, wherein said composition is substantially free of other added active ingredients.

9. The composition of claim 8, wherein said other active ingredient is another antibacterial.

10. The composition of claim 8, wherein said other active ingredient is another anti-inflammatory.

11. The composition of claim 8, wherein said other active ingredient is another anti-septic.

12. The composition of claim 9, wherein said antibacterial is selected from one or more of the group consisting of acedapsone;

acetosulfone sodium;

alamecin;

alexidine;

amdinocillin;

amdinocillin pivoxil;

amicycline;

amifloxacin;

amifloxacin mesylate;

amikacin;

amikacin sulfate;

aminosalicylic acid;

aminosalicylate sodium;

amoxicillin;

amphomycin;

ampicillin;

ampicillin sodium;

apalcillin sodium;

apramycin;

aspartocin;

astromicin sulfate;

avilamycin;

avoparcin;

azithromycin;

azlocillin;

azlocillin sodium;

bacampicillin hydrochloride;

bacitracin;

bacitracin methylene disalicylate;

bacitracin zinc;

bambermycins;

benzoylpas calcium;

berythromycin;

betamicin sulfate;

biapenem;

biniramycin;

biphenamine hydrochloride;

bispyrithione magsulfex;

butikacin;

butirosin sulfate;

capreomycin sulfate;

carbadox;

carbenicillin disodium;

carbenicillin indanyl sodium;

carbenicillin phenyl sodium;

carbenicillin potassium;

carumonam sodium;

cefaclor;

cefadroxil;

cefamandole;

cefamandole nafate;

cefamandole sodium;

cefaparole;

cefatrizine;

cefazaflur sodium;

cefazolin;

cefazolin sodium;

cefbuperazone;

cefdinir;

cefepime;

cefepime hydrochloride;

cefetecol;

cefixime;

cefmenoxime hydrochloride;

cefmetazole;

cefmetazole sodium;

cefonicid monosodium;

cefonicid sodium;

cefoperazone sodium;

ceforanide;

cefotaxime sodium;

cefotetan;

cefotetan disodium;

cefotiam hydrochloride;

cefoxitin;

cefoxitin sodium;

cefpimizole;

cefpimizole sodium;

cefpiramide;

cefpiramide sodium;

cefpirome sulfate;

cefpodoxime proxetil;

cefprozil;

cefroxadine;

cefsulodin sodium;

ceftazidime;

ceftibuten;

ceftizoxime sodium;

ceftriaxone sodium;

cefuroxime;

cefuroxime axetil;

cefuroxime pivoxetil;

cefuroxime sodium;

cephacetrile sodium;

cephalexin;

cephalexin hydrochloride;

cephaloglycin;

cephaloridine;

cephalothin sodium;

cephapirin sodium;

cephradine;

cetocycline hydrochloride;

cetophenicol;

chloramphenicol;

chloramphenicol palmitate;

chloramphenicol pantothenate complex;

chloramphenicol sodium succinate;

chlorhexidine phosphanilate;

chlortetracycline bisulfate;

chlortetracycline hydrochloride;

cinoxacin;

ciprofloxacin;

ciprofloxacin hydrochloride;

cirolemycin;

clarithromycin;

clinafloxacin hydrochloride;

clindamycin;

clindamycin hydrochloride;

clindamycin palmitate hydrochloride;

clindamycin phosphate;

clofazimine;

cloxacillin benzathine;

cloxacillin sodium;

cloxyquin;

colistimethate sodium;

colistin sulfate;

coumermycin;

coumermycin sodium;

cyclacillin;

cycloserine;

dalfopristin;

dapsone;

daptomycin;

demeclocycline;

demeclocycline hydrochloride;

demecycline;

denofungin;

diaveridine;

dicloxacillin;

dicloxacillin sodium;

dihydrostreptomycin sulfate;

dipyrithione;

dirithromycin;

doxycycline;

doxycycline calcium;

doxycycline fosfatex;

doxycycline hyclate;

droxacin sodium;

enoxacin;

epicillin;

epitetracycline hydrochloride;

erythromycin;

erythromycin acistrate;

erythromycin estolate;

erythromycin ethylsuccinate;

erythromycin gluceptate;

erythromycin lactobionate;

erythromycin propionate;

erythromycin stearate;

ethambutol hydrochloride;

ethionamide;

fleroxacin;

floxacillin;

fludalanine;

flumequine;

fosfomycin;

fosfomycin tromethamine;

fumoxicillin;

furazolium chloride;

furazolium tartrate;

fusidate sodium;

fusidic acid;

ganciclovir, ganciclovir sodium;

gentamicin sulfate;

gloximonam;

gramicidin;

haloprogin;

hetacillin;

hetacillin potassium;

hexedine;

ibafloxacin;

imipenem;

isoconazole;

isepamicin;

isoniazid;

josamycin;

kanamycin sulfate;

kitasamycin;

levofuraltadone;

levopropylcillin potassium;

lexithromycin;

lincomycin;

lincomycin hydrochloride;

lomefloxacin;

lomefloxacin hydrochloride;

lomefloxacin mesylate;

loracarbef;

mafenide;

meclocycline;

meclocycline sulfosalicylate;

megalomicin potassium phosphate;

mequidox;

meropenem;

methacycline;

methacycline hydrochloride;

methenamine;

methenamine hippurate;

methenamine mandelate;

methicillin sodium;

metioprim;

metronidazole hydrochloride;

metronidazole phosphate;

mezlocillin;

mezlocillin sodium;

minocycline;

minocycline hydrochloride;

mirincamycin hydrochloride;

monensin;

monensin sodiumr;

nafcillin sodium;

nalidixate sodium;

nalidixic acid;

natainycin;

nebramycin;

neomycin palmitate;

neomycin sulfate;

neomycin undecylenate;

netilmicin sulfate;

neutramycin;

nifuiradene;

nifuraldezone;

nifuratel;

nifuratrone;

nifurdazil;

nifurimide;

nifiupirinol;

nifurquinazol;

nifurthiazole;

nitrocycline;

nitrofurantoin;

nitromide;

norfloxacin;

novobiocin sodium;

ofloxacin;

onnetoprim;

oxacillin and oxacillin sodium;

oximonam;

oximonam sodium;

oxolinic acid;

oxytetracycline;

oxytetracycline calcium;

oxytetracycline hydrochloride;

paldimycin;

parachlorophenol;

paulomycin;

pefloxacin;

pefloxacin mesylate;

penamecillin;

penicillins such as penicillin g benzathine, penicillin g potassium, penicillin g procaine, penicillin g sodium, penicillin v, penicillin v benzathine, penicillin v hydrabamine, and penicillin v potassium;

pentizidone sodium;

phenyl aminosalicylate;

piperacillin sodium;

pirbenicillin sodium;

piridicillin sodium;

pirlimycin hydrochloride;

pivampicillin hydrochloride;

pivampicillin pamoate;

pivampicillin probenate;

polymyxin b sulfate;

porfiromycin;

propikacin;

pyrazinamide;

pyrithione zinc;

quindecamine acetate;

quinupristin;

racephenicol;

ramoplanin;

ranimycin;

relomycin;

repromicin;

rifabutin;

rifametane;

rifamexil;

rifamide;

rifampin;

rifapentine;

rifaximin;

rolitetracycline;

rolitetracycline nitrate;

rosaramicin;

rosaramicin butyrate;

rosaramicin propionate;

rosaramicin sodium phosphate;

rosaramicin stearate;

rosoxacin;

roxarsone;

roxithromycin;

sancycline;

sanfetrinem sodium;

sarmoxicillin;

sarpicillin;

scopafungin;

sisomicin;

sisomicin sulfate;

sparfloxacin;

spectinomycin hydrochloride;

spiramycin;

stallimycin hydrochloride;

steffimycin;

streptomycin sulfate;

streptonicozid;

sulfabenz;

sulfabenzamide;

sulfacetamide;

sulfacetamide sodium;

sulfacytine;

sulfadiazine;

sulfadiazine sodium;

sulfadoxine;

sulfalene;

sulfamerazine;

sulfameter;

sulfamethazine;

sulfamethizole;

sulfamethoxazole;

sulfamonomethoxine;

sulfamoxole;

sulfanilate zinc;

sulfanitran;

sulfasalazine;

sulfasomizole;

sulfathiazole;

sulfazamet;

sulfisoxazole;

sulfisoxazole acetyl;

sulfisboxazole diolamine;

sulfomyxin;

sulopenem;

sultamicillin;

suncillin sodium;

talampicillin hydrochloride;

teicoplanin;

temafloxacin hydrochloride;

temocillin;

tetracycline;

tetracycline hydrochloride;

tetracycline phosphate complex;

tetroxoprim;

thiamphenicol;

thiphencillin potassium;

ticarcillin cresyl sodium;

ticarcillin disodium;

ticarcillin monosodium;

ticlatone;

tiodonium chloride;

tobramycin;

tobramycin sulfate;

tosufloxacin;

trimethoprim;

trimethoprim sulfate;

trisulfapyrimidines;

troleandomycin;

trospectomycin sulfate;

tyrothricin;

vancomycin;

vancomycin hydrochloride;

virginiamycin and zorbamycin

13. The composition of claim 10, wherein said anti-inflammatory is selected from one of more of the group consisting of hydroxyltriamcinolone alphamethyl dexamethasone, dexamethasone-phosphate, beclomethasone dipropionate, clobetasol valerate, desonide, desoxymethasone, desoxycorticosterone acetate, dexamethasone, dichlorisone, diflorasone diacetate, diflucortolone valerate, fluadrenolone, fluclarolone acetonide, fludrocortisone, flumethasone pivalate, fluosinolone acetonide, fluocinonide, flucortine butylester, fluocortolone, fluprednidene (fluprednylidene)acetate, flurandrenolone, halcinonide, hydrocortisone acetate, hydrocortisone butyrate, methylprednisolone, triamcinolone acetonide, cortisone, cortodoxone, flucetonide, fludrocortisone, difluorosone diacetate, fluradrenalone acetonide, medrysone, amc, amcinafide, betamethasone and the balance of its esters, chlorprednisone, chlorprednisone acetate, clocortelone, clescinolone, dichlorisone, difluprednate, flucloronide, flunisolide, fluoromethalone, fluperolone, fluprednisolone, hydrocortisone valerate, hydrocortisone cyclopentylproprionate, hydrocortamate, meprednisone, paramethasone, prednisolone, prednisone, beclomethasone dipropionate, betamethasone dipropionate, triamcinolone prostaglandin H synthetase inhibitors (Cox I or Cox II), flurbiprofen, ketorolac, suprofen, nepafenac, amfenac, indomethacin, naproxen, ibuprofen, bromfenac, ketoprofen, meclofenamate, piroxicam, sulindac, mefanamic acid, diflusinal, oxaprozin, tolmetin, fenoprofen, benoxaprofen, nabumetome, etodolac, phenylbutazone, aspirin, oxyphenbutazone, NCX-4016, HCT-1026, NCX-284, NCX-456, tenoxicam, carprofen, cyclooxygenase type II selective inhibitors, vioxx, celecoxib, P54, etodolac, L-804600, S-33516;

PAF antagonists, A-137491, ABT-299, apafant, bepafant, minopafant, E-6123, BN-50727, nupafant, modipafant, PDE IV inhibitors, ariflo, torbafylline, rolipram, filaminast, piclamilast, cipamfylline, CG-1088, V-11294A, CT-2820, PD-168787, CP-293121, DWP-205297, CP-220629, SH-636, BAY-19-8004, and roflumilast.

14. The composition of claim 11, wherein said anti-septic is selected from one or more of the group consisting of cetyl trimethylammonium bromide, cetylpyridinium chloride, cetylpyridinium chloride, benzethonium chloride, 2% aqueous iodine, boric acid, chlorhexidine gluconate, hydrogen peroxide, octenidine dihydrochloride, ethanol, isopropanol, n-propanol, phenylethyl alcohol, benzyl alcohol, and phenoxyethyl alcohol.

94. A composition consisting of chloroxylenol, hydrocortisone, benzalkonium chloride and one or more excipients.

95. The composition of claim 94, wherein said composition has about 1.5 mg to about 0.5 mg chloroxylenol per 1 ml of solution, about 15 mg to about 5 mg hydrocortisone per 1 ml of solution, and about 0.15 mg to about 0.05 mg benzalkonium chloride per 1 ml of solution.

96. The composition of claim 95, wherein said composition has about 1.0 mg chloroxylenol per 1 ml of solution, about 10 mg hydrocortisone per 1 ml of solution, and about 0.10 mg benzalkonium chloride per 1 ml of solution.

97. A method consisting of administering to a patient the composition of claim 94.

98. The method of claim 97, wherein said composition has about 1.5 mg to about 0.5 mg chloroxylenol per 1 ml of solution, about 15 mg to about 5 mg hydrocortisone per 1 ml of solution, and about 0.15 mg to about 0.05 mg benzalkonium chloride per 1 ml of solution.

99. The method of claim 98, wherein said composition has about 1.0 mg chloroxylenol per 1 ml of solution, about 10 mg hydrocortisone per 1 ml of solution, and about 0.10 mg benzalkonium chloride per 1 ml of solution.