Electrophysiological assessment of the integrity of cerebral vasculature
First Claim
1. A method for monitoring blood flow in at least one region of cerebral vasculature of a subject, the method comprising:
- a. determining an electrophysiological activity in the at least one region of the cerebral vasculature using a non-invasive technique;
b. determining a deviation of the electrophysiological activity from a baseline of electrophysiological activity attributed to the at least one region of the cerebral vasculature; and
c. determining the blood flow in specific branches of the at least one region of the cerebral vasculature based on the deviation.
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Abstract
The present invention discloses a method for monitoring the blood flow in the cerebral vasculature of a subject. The method includes measuring the electrophysiological activity of different regions in the brain in the excited or unexcited state. The measured electrophysiological activity of each region is then compared with the baseline of the electrophysiological activity of that region for the corresponding state. External stimuli or the performance of specific tasks by the subject can be used to excite different regions of the brain. Any deviation in the measured electrophysiological activity from the baseline indicates an altered blood flow in that region of the brain. Identification of this particular region of the brain which has altered activity can be carried out based on the external stimuli that resulted in the altered activity. Specific branches of the cerebral vasculature with an altered blood flow may also be determined based on the regions of the brain showing altered electrophysiological activity.
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Citations
25 Claims
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1. A method for monitoring blood flow in at least one region of cerebral vasculature of a subject, the method comprising:
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a. determining an electrophysiological activity in the at least one region of the cerebral vasculature using a non-invasive technique; b. determining a deviation of the electrophysiological activity from a baseline of electrophysiological activity attributed to the at least one region of the cerebral vasculature; and c. determining the blood flow in specific branches of the at least one region of the cerebral vasculature based on the deviation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for monitoring blood flow in at least one region of a cerebral vasculature of a subject, the method comprising:
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a. instructing the subject to perform at least one specific task, wherein the subject performs the at least one specific task; b. determining an electrophysiological activity in the at least one region of the cerebral vasculature using a non-invasive technique; c. determining a deviation of the electrophysiological activity from a baseline of electrophysiological activity attributed to the at least one region of the cerebral vasculature; and d. determining the blood flow in specific branches of the at least one region of the cerebral vasculature based on the deviation. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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23. A computer program product for use with a computer stored program, the computer program product comprising a computer readable medium having a computer readable program code embodied therein for monitoring blood flow in at least one region of cerebral vasculature of a subject, the computer readable program code including instructions for:
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a. determining an electrophysiological activity in the at least one region of the cerebral vasculature using a non-invasive technique; b. determining a deviation of the electrophysiological activity from a baseline of electrophysiological activity attributed to the at least one region of the cerebral vasculature; and c. determining the blood flow in specific branches of the at least one region of the cerebral vasculature based on the deviation.
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24. A computer program product for use with a computer stored program, the computer program product comprising a computer readable medium having a computer readable program code embodied therein for monitoring blood flow in at least one region of cerebral vasculature of a subject, the computer readable program code including instructions for:
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a. instructing the subject to perform at least one specific task, wherein the subject performs the at least one specific task; b. determining an electrophysiological activity in the at least one region of the cerebral vasculature using a non-invasive technique; c. determining a deviation of the electrophysiological activity from a baseline of electrophysiological activity attributed to the at least one region of the cerebral vasculature; and d. determining the blood flow in specific branches of the at least one region of the cerebral vasculature based on the deviation.
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25. A computer program product for use with a computer stored program, the computer program product comprising a computer readable medium having a computer readable program code embodied therein for monitoring blood flow in at least one region of cerebral vasculature of a subject, the computer readable program code including instructions for:
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a. providing at least one external stimulus to the subject; b. determining an electrophysiological activity in the at least one region of the cerebral vasculature using a non-invasive technique; c. determining a deviation of the electrophysiological activity from a baseline of electrophysiological activity attributed to the at least one region of the cerebral vasculature; and d. determining the blood flow in specific branches of the at least one region of the cerebral vasculature based on the deviation.
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Specification