CARTRIDGE ELECTRODE DEVICE

• US 20090112205A1
• Filed: 02/01/2008
• Published: 04/30/2009
• Est. Priority Date: 10/31/2007
• Status: Abandoned Application

• Current Assignee: Syneron Medical Limited (Syneron Incorporated)
• Original Assignee: Primaeva Medical, Inc. (Syneron Incorporated)
• Inventors: Knopp, Peter G., McGill, Scott A., Mehta, Bankim H.
• Application Number:
  US12/024,925
• Publication Number:
  US 20090112205A1
• Time in Patent Office: Days
• US Class Current: 606/41
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 18/1402 Probes for open surgery
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 2018/00047 using Peltier effect
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/0047 Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
• CPC Class Codes: A61B 2018/00994 combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound
• CPC Class Codes: A61B 2018/1475 Electrodes retractable in or deployable from a housing

Abstract

The invention provides a system and method for achieving the cosmetically beneficial effects of shrinking collagen tissue in the dermis or other areas of tissue in an effective, non-invasive manner using an array of electrodes. Systems described herein allow for improved treatment of tissue. Additional variations of the system include array of electrodes configured to minimize the energy required to produce the desired effect.

Claims

1. An energy delivery device for applying energy from an energy source to treat a target region beneath a surface of tissue, the device comprising:

a device body having a handle portion, a cartridge receiving surface, an actuator adjacent thereto and a plurality of electrically conductive leads on at least a portion of the cartridge receiving surface and being electrically coupleable to the energy source, where the actuator is moveable relative to the device body;

a cartridge body removably coupled to the device body on the cartridge receiving surface, the cartridge body comprising an electrode assembly in engagement with the actuator, the electrode assembly having a plurality of electrodes arranged in an array and where at least one electrode has a connection portion, the electrode assembly being moveable between a treatment position and a retracted position upon movement of the actuator, such that in the treatment position the at least one electrode extends from the cartridge body and the respective connection portion engages one electrically conductive lead, and in the retracted position, the at least one electrode retracts into the cartridge and the respective connection portion moves out of engagement with the electrically conductive lead preventing delivery of energy.

2. The energy delivery device of claim 1, the cartridge body further comprising a tissue, engaging surface, where a plane of the tissue engaging surface forms an oblique angle relative to a plane of the array of the electrodes, such that when extended the from the cartridge body the electrodes extend at the oblique angle relative to the tissue engaging surface, where placement of the tissue engaging surface against tissue allows for entry of the electrodes into the tissue at the oblique angle.

3. The energy delivery device of claim 1, the plurality of electrodes comprises a first plurality of electrodes arranged in a first array, and a second plurality of electrodes arranged in a second array.

4. The energy delivery device of claim 3, where the first plurality of electrodes comprise a first length, and the second plurality of electrodes comprise a second length, where the first and second length are not equal such that upon insertion into tissue, each plurality of needles extends a same vertical length into the tissue.

5. The energy delivery device of claim 3, where at least one of the first plurality of electrodes are offset from the second plurality of electrodes such that upon insertion into tissue, the plurality of electrodes does not create a continuous line of insertion points along the plurality of electrodes.

6. The energy delivery device of claim 1, the plurality of electrodes comprises a plurality of electrode pairs, where at least one electrode pair is vertically offset from an adjacent electrode pair so that insertion of electrode pairs into the tissue does not create a continuous line of insertion points.

7. The energy delivery device of claim 6, where at least one of the electrode pairs is axially offset from an adjacent electrode pair.

8. The energy delivery device of claim 1, where the actuator is coupled to a spring means and is spring loaded.

9. The energy delivery device of claim 8, where the spring means comprises a spring force when restrained and when unrestrained applies the spring force to the actuator to drive electrode assembly from the retracted position to the treatment position with sufficient force for the electrodes to penetrate the surface of the tissue.

10. The energy delivery device of claim 1, where the actuator is slidable or rotatable relative to the device body.

11. The energy delivery device of claim 1, where the device body is configured to allow single handed deployment of the actuator.

12. The energy delivery device of claim 1, where the actuator is coupled to a compressed fluid cylinder, having a valve for driving the actuator.

13. The energy delivery device of claim 1, where a number of the conductive leads is greater than a number of the electrodes.

14. The energy delivery device of claim 1, where at least one of the electrodes comprises a temperature detecting element.

15. The energy delivery device of claim 14, where the plurality of electrically conductive leads comprise a first set of energy leads and a second set of temperature detecting leads, and where the energy leads and the temperature detecting leads are electrically isolated from each other.

16. The energy delivery device of claim 14, where each connection portion of the electrode comprises a energy connection portion and a temperature detecting connection portion, and where in the treatment position, the energy connection portion contacts at least one energy lead and the temperature detecting portion contacts one temperature detecting lead.

17. The energy delivery device of claim 16, where the temperature detecting portion also contacts the temperature detecting, lead in the retracted portion.

18. The energy delivery device of claim 14, where the temperature detecting element is configured to detect a temperature of the electrode in both the retracted position and the treated position.

19. The energy delivery device of claim 1, where the device body further comprises a cooling surface removably coupled adjacent to the cartridge receiving surface such that when the electrode array is in the treatment position and the electrodes are inserted into tissue, the cooling surface is positioned to engage an area of the tissue surface directly above the electrodes, and where the cooling surface is adapted to maintain a temperature at, below, or slightly above body temperature.

20. The energy delivery device of claim 19, where the cooling surface is visually transparent.

21. The energy delivery device of claim 19, where the cooling surface is visually translucent.

22. The energy delivery device of claim 19, where the cooling surface comprises a material selected from the group consisting of steel, aluminum, and copper.

23. The energy delivery device of claim 19, where the plurality of electrodes pass through a portion of the cooling surface when advanced from the device body.

24. The energy delivery device of claim 19, further comprising a thermoelectric cooling device coupled to the power supply and in contact with the cooling surface, where the thermoelectric cooling device maintains the temperature.

25. The energy delivery device of claim 24, where the plurality of electrodes pass through a portion of the thermoelectric cooling device when advanced from the device body.

26. The energy delivery device of claim 24, where the thermoelectric cooling device comprises a Peltier cooling device.

27. The energy delivery device of claim 19 further comprising a fluid source coupled to the cooling surface, where the fluid source is adapted to maintain the temperature.

28. The energy deliver), device of claim 1, where each of the electrodes has a respective impedance along a respective active region, and wherein the impedance of at least one of the electrodes varies along its respective active region.

29. The energy delivery device of claim 28, where the impedance of each of the plurality of electrodes varies along the respective active region.

30. The energy delivery device of claim 1, where at least one electrode in the plurality of electrodes comprises a section of insulation over a portion of an active region.

31. The energy delivery device of claim 1, where the device body further comprises an ink-pad having ink and located on an exterior surface, where the ink pad marks tissue upon contact therewith.

32. The energy delivery device of claim 1, where the device body further comprises a marking lumen for spraying an ink on an exterior surface of the tissue.

33. The energy delivery device of claim 1, where the cartridge body further comprises a marking lumen for spraying an ink on an exterior surface of the tissue.

34. The energy delivery device of claim 1, where the tissue engaging surface further comprises at least one sensor for detecting contact with the surface of tissue.

35. A kit for applying therapeutic energy to tissue, the kit comprising:

a device body having a handle portion, a cartridge receiving surface, an actuator adjacent thereto and a plurality of electrically conductive leads on at, least a portion of the cartridge receiving surface and being electrically coupleable to the energy source;

a plurality of cartridge bodies, each cartridge body capable of being removably coupled to the device body on the cartridge receiving surface, each cartridge body comprising an electrode assembly in engagement with the actuator, the electrode assembly having a plurality of electrodes having an active region and arranged in an array and at least one electrode having a connection portion, the electrode assembly being moveable between a treatment position and a retracted position upon movement of the actuator, such that in the treatment position the at least one electrode extends from the cartridge body and the respective connection portion contacts one electrically conductive lead, and in the retracted position the at least one electrode retracts into the cartridge and the respective connection portion moves out of engagement with the electrically conductive lead preventing delivery of energy, and

where the electrode assembly on each respective cartridge body has a different configuration.

36. The kit of claim 35, where a number of electrodes in a first cartridge body is different from a length of the electrodes in a second cartridge body.

37. The kit of claim 35, where a length of the electrodes in a first cartridge body is different from a length of the electrodes in a second cartridge body.

38. The kit of claim 35, where a gauge of the electrodes in a first cartridge body is different from a gauge of the electrodes in a second cartridge body.

39. The kit of claim 35, where the active region of the electrodes in a first cartridge body is different from the active region of the electrodes in a second cartridge body.

40. The kit of claim 35, where the plurality of electrodes in at least a first cartridge body comprises a first plurality of electrodes arranged in a first array, and a second plurality of electrodes arranged in a second array.

41. The kit of claim 40, where at least one of the first plurality of electrodes are offset from the second plurality of electrodes such that upon insertion into tissue, the plurality of electrodes does not create a continuous line of insertion points along the plurality of electrodes.

42. The kit of claim 41, where a second cartridge body comprises a first plurality and a second plurality of electrodes where the first and second plurality of electrodes are offset, and where the offset of the first cartridge body is different from the offset of the second cartridge body.

43. The kit of claim 35, where the plurality of electrodes on a first cartridge body comprises a plurality of electrode pairs, where at least one electrode pair is vertically offset from an adjacent electrode pair so that insertion of electrode pairs into the tissue does not create a continuous line of insertion points.

44. The kit of claim 43, where at least one of the electrode pairs is axially offset from an adjacent electrode pair.

45. The kit of claim 35, where a spacing between the electrodes in a first cartridge body is different from the spacing between the electrodes in a second cartridge body.

46. A method for applying energy to a region of tissue from a energy source, comprising:

placing a tissue engaging surface of an electrode device against a surface of the tissue, where the electrode device comprises a plurality of electrodes having a retracted position within the electrode device and a treatment position in which the electrodes extend from the treatment, device at an oblique angle relative to the tissue engaging surface, at least one electrode including an active region at a distal portion thereof, wherein the electrodes are decoupled from the energy source when in the retracted position;

deploying the electrodes to the treatment positions in which the electrodes are coupled to the energy source;

applying energy to tissue at the active region of the electrode.

47. The method of claim 46, where at least a portion of the electrodes are offset from an adjacent electrode such that insertion of the electrodes into tissue does not create a continuous line of insertion points.

48. The method of claim 46, where the plurality of electrodes comprise a set of electrodes and where the set of electrodes are detachable from the electrode device.

49. The method of claim 48, further comprising replacing the plurality of electrodes with a second set of electrodes, where at least one feature of the second set of electrodes is chosen based on the region of tissue

50. The method of claim 46, further comprising placing a cooling surface adjacent to an entry point of the electrodes, where the cooling surface directly cools the exterior surface of the tissue directly above the active region of the electrode.

51. The method of claim 46, where the cooling surface is visually transparent.

52. The method of claim 46, where the cooling surface is visually translucent.

53. The method of claim 46, where the cooling surface comprises a material selected from the group consisting of steel, aluminum, and copper.

54. The method of claim 46, where the plurality of electrodes pass through a portion of the cooling surface when inserting the electrodes into the tissue.

55. The method of claim 46, where inserting the plurality of electrodes comprises first applying an impact force to the electrodes such that the electrodes penetrate the tissue and subsequently, advancing the electrodes farther into the tissue.

56. The method of claim 46, further comprising:

placing a portion of the surface, of the tissue that is adjacent to each electrode in a state of traction as the electrodes are inserted into the tissue;

advancing at least one of the electrodes through the surface layer;

applying energy to at least one of the electrodes to create a thermal injury to tissue beneath the surface layer.

57. The method of claim 56, where each electrode extends through an opening in an introducer member, where pressing the introducer member against the surface layer places the surface layer in traction.

58. The method of claim 56, further comprising a power supply configured to energize adjacent electrodes at different times.

59. The method of claim 46, where the region of tissue comprises tissue selected from the dermis, a tumor, a hair follicle, sebaceous gland, a skin anomaly such as acne, wart or other structure or blemish, and a blood vessel.

60. An energy delivery device for applying energy from an energy source to treat a target region beneath a surface of tissue, the device comprising:

a device body having a handle portion, a cartridge receiving surface, a spring-loaded actuator adjacent thereto and a plurality of electrically conductive leads on at least a portion of the cartridge receiving surface and being electrically coupleable to the energy source;

a cartridge body removably coupled to the device body on the cartridge receiving surface, the cartridge body comprising an electrode assembly in engagement with the actuator, the electrode assembly having a plurality of electrodes arranged in an array and each electrode having a connection portion, the electrode assembly being moveable between a treatment position and a retracted position upon movement of the actuator, such that in the treatment position each electrode extends from the cartridge body and the respective connection portion contacts one electrically conductive lead, and in the retracted position, each electrode retracts into the cartridge and the respective connection portion moves out of engagement with the electrically conductive lead preventing delivery of energy.

61. The energy delivery device of claim 60, the cartridge body further comprising a tissue engaging surface, where a plane of the tissue engaging surface forms an oblique angle relative to a plane of the array of the electrodes, such that when extended the form the cartridge body the electrodes extend at the oblique angle relative to the tissue engaging surface, where placement of the tissue engaging surface against tissue allows for entry of the electrodes into the tissue at the oblique angle.