MEDICAL DEVICE FOR MODIFICATION OF LEFT ATRIAL APPENDAGE AND RELATED SYSTEMS AND METHODS

• US 20090112249A1
• Filed: 10/17/2008
• Published: 04/30/2009
• Est. Priority Date: 10/19/2007
• Status: Active Grant

• Current Assignee: Coherex Medical, Inc. (Johnson & Johnson)
• Original Assignee: Coherex Medical, Inc. (Johnson & Johnson)
• Inventors: Whisenant, Brian K., Edmiston, Daryl R., Miles, Scott D., Davis, Clark C., Linder, Richard J., Fox, DeWayne C.
• Granted Patent: US 8,845,711 B2
• Time in Patent Office: Days
• US Class Current: 606/192
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12122 within the heart for closing a cardiac septal defect A61B17/0057
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/12159 Solid plugs; being solid before insertion
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/00898 expandable upon contact with fluid
• CPC Class Codes: A61B 2017/0412 having anchoring barbs or pins extending outwardly from suture anchor body
• CPC Class Codes: A61B 2017/0427 having anchoring barbs or pins extending outwardly from the anchor body
• CPC Class Codes: A61B 2017/0649 Coils or spirals
• CPC Class Codes: A61B 2017/1205 Introduction devices

Abstract

Several embodiments are set forth of devices, systems and methods for modifying an atrial appendage such as a left atrial appendage (LAA). In one embodiment, a device includes a body that is collapsible and self-expanding. The body includes a textured surface with protruding portions and recessed portions. The body may be formed of a reticulated foam material and may exhibit a substantially spherical geometry or a truncated spherical geometry. The body may be substantially hollow. In one embodiment, portions of the textured surface may be metalized or have a coating placed thereon to enhance frictional engagement of the body with the atrial appendage wall. In another embodiment, a mesh bag is disposed within an LAA and one or more self-expanding bodies are disposed within the mesh bag. The mesh bag is then secured to retain the self-expanding bodies within the bag and the LAA.

Claims

1. A medical device for modifying a left atrial appendage (LAA), comprising:

a body formed of a self-expanding material, the body exhibiting a textured surface including a plurality of protruding portions and a plurality of recesses, each protruding portion being separated from an adjacent protruding portion by a recess of the plurality of recesses.

2. The medical device of claim 1, wherein the body, when in an expanded state, exhibits a substantially spherical geometry.

3. The medical device of claim 2, further comprising a substantially hollow cavity defined within an interior of the body.

4. The medical device of claim 1, wherein the body is formed of a material comprising foam.

5. The medical device of claim 1, wherein the body is formed of a material comprising at least one of a polymer foam, polyurethane, polyester, and polyvinyl acetate.

6. The medical device of claim 1, wherein the body, when in an expanded state, substantially exhibits a geometry of a truncated sphere.

7. The medical device of claim 6, wherein an opening is defined within a surface at the truncated end of the sphere and wherein the opening exposes an internal cavity of the body.

8. The medical device of claim 1, further comprising a coating of metal or graphite on at least some of the protruding portions.

9. The medical device of claim 8, wherein, when in a collapsed state, the protruding portions that are intended to engage a surface of delivery mechanism are substantially devoid of any metal or graphite coating.

10. The medical device of claim 1, further comprising a mesh bag disposed about the body.

11. The medical device of claim 1, further comprising a plurality of ties circumscribing the body, wherein each tie is disposed in a recess of the plurality of recesses.

12. The medical device of claim 1, further comprising at least one radio opaque marker associated with the body.

13. A medical device for modifying a left atrial appendage (LAA), comprising:

a mesh bag;

at least one self-expanding body disposed within the mesh bag.

14. The medical device of claim 13, wherein the at least one self-expanding body includes a plurality of self-expanding bodies.

15. The medical device of claim 14, wherein the mesh bag is formed of a material comprising at least one of nylon, polyester or silicone.

16. The medical device of claim 14, wherein the plurality of self-expanding bodies includes a plurality of foam bodies.

17. The medical device of claim 16, wherein the plurality of foam bodies are formed of a material comprising at least one of a polymer foam, polyurethane, and polyvinyl acetate.

18. The medical device of claim 14, further comprising at least one radio opaque marker associated with the mesh bag or at least one of the plurality of self-expanding bodies.

19. A method of modifying a left atrial appendage (LAA), the method comprising:

providing a body formed of a self-expanding material, the body exhibiting a textured surface including a plurality of protruding portions and a plurality of recesses, each protruding portion being separated from an adjacent protruding portion by a recess of the plurality of recesses;

compressing the body within a delivery vehicle;

positioning a portion of the delivery vehicle adjacent an opening of the LAA;

discharging the body from the delivery vehicle into the LAA; and

expanding the body to engage a side wall of the LAA and substantially occlude an opening of the LAA.

20. A method of modifying a left atrial appendage (LAA), the method comprising:

disposing a mesh bag within the LAA;

disposing at least one self-expanding body within an interior of the mesh bag; and

securely closing the mesh bag to retain the at least one self-expanding body within the bag.

21. The method according to claim 20, wherein disposing at least one self-expanding body within an interior of the mesh bag further includes disposing a plurality of self-expanding bodies within the interior of the mesh bag.

22. A medical device for modifying a left atrial appendage (LAA), comprising:

a first frame member having a first flat configuration and configured to anchor within the LAA;

a second frame member having a second flat configuration, wherein the first and second frame members are non-coplanar;

a spring member connected between the first frame member and the second frame member; and

a tissue in-growth member attached to the second frame member and configured to cover an opening of the LAA.

23. A medical device for modifying a left atrial appendage (LAA), comprising:

a frame member having a substantially flat configuration, the frame member including distal anchor members for anchoring the frame member within the LAA; and

a tissue in-growth member attached to the frame member and configured to cover an opening of the LAA.

24. A medical device for modifying a left atrial appendage (LAA), comprising:

a frame member including an anchoring system configured to anchor the frame member at least partially within the LAA; and

a tissue in-growth member attached to the frame member and configured to prevent potential embolic material from escaping the LAA.