RECOMBINANT EXPRESSED BIOADSORBABLE POLYHYDROXYALKONATE MONOFILAMENT AND MULTI-FILAMENTS SELF-RETAINING SUTURES
First Claim
1. A self-retaining suture comprising at least one filament, wherein the at least one filament includes:
- a recombinant polyhydroxyalkonate (rPHA) polymer; and
at least one tissue retainer, where the tissue retainer is introduced into at least one of the at least one filament to improve retention of the suture in tissue.
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Accused Products
Abstract
The present invention provides polymers made by genetically engineering microorganisms for making a self-retaining suture. In an embodiment of the present invention the genetically engineering microorganisms synthesize polyhydroxyalkanoate (PHA) polymers. In an alternate embodiment of the invention, the genetically engineering microorganisms synthesize polybetahydroxybutyrate (PHB) polymers. In an alternative embodiment of the invention, the self-retaining sutures can be made from a copolymer such as polyhydroxybutyratevalerate (PHBV), where the genetically engineering microorganisms produces PHA polymers as the monofilament base material and a different genetically engineering microorganisms produces polyhydroxybutyratevalerate (PHBV) polymers. In various embodiments of the invention, recombinant expressed self-retaining suture materials have a melting point in the range from between approximately 40° C. to approximately 180° C. In various embodiments of the invention, recombinant expressed self-retaining suture materials have extension-to-break strength of between approximately 8% and approximately 42%.
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Citations
20 Claims
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1. A self-retaining suture comprising at least one filament, wherein the at least one filament includes:
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a recombinant polyhydroxyalkonate (rPHA) polymer; and at least one tissue retainer, where the tissue retainer is introduced into at least one of the at least one filament to improve retention of the suture in tissue. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A self-retaining suture comprising:
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at least one filament, wherein at least one of the filaments includes a recombinant polyhydroxyalkonate (rPHA) copolymer; and at least one tissue retainer, where the tissue retainer is introduced into the at least one rPHA filament to improve retention of the suture in tissue. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification