Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma
First Claim
1. An apparatus for freeze-drying a liquid material, said apparatus comprising:
- a first collapsible container;
a tubing connected to said first collapsible material; and
a permeable membrane in fluid-tight, vapor connection with said tubing, said membrane being separate from said first collapsible container.
4 Assignments
0 Petitions
Accused Products
Abstract
A flexible container receives a liquid material, which is freeze-dried in situ within the flexible container. A gas permeable material that is separate from the flexible container provides gas transport for sublimation during drying and lyophilization. The gas permeable portion of the system can be isolated and removed from the flexible container post-lyophilzation The freeze-dried material is stored in the flexible container until administration is necessary. The flexible container receives a reconstituting liquid for mixing with the freeze-dried material, and conveys the reconstituted freeze-dried material from the flexible container for administration to an individual.
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Citations
34 Claims
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1. An apparatus for freeze-drying a liquid material, said apparatus comprising:
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a first collapsible container; a tubing connected to said first collapsible material; and a permeable membrane in fluid-tight, vapor connection with said tubing, said membrane being separate from said first collapsible container. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of freeze-drying a liquid comprising the steps of:
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providing an apparatus for receiving a liquid, said apparatus comprising; a first flexible container; a tubing connected to said first flexible container; a permeable membrane attached to said tubing, said membrane being separate from said first flexible container; and a first liquid port for receiving said liquid; a second liquid port for receiving a pH adjusting solution; filling said first flexible container with said liquid; and freeze-drying said liquid within said first flexible container. - View Dependent Claims (19, 20)
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21. A method comprising the steps of:
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providing an apparatus for receiving a liquid, said apparatus comprising; a first flexible container; a tubing connected to said flexible container; a separate permeable membrane attached to said tubing; a liquid port for introducing said liquid; a second liquid port for introducing a pH adjusting solution; an administration port; and a reconstitution port; introducing liquid into said apparatus through said liquid port; and freeze-drying said liquid within said first flexible container during a lyophilization process. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification