INJECTABLE BIODEGRADABLE PARTICLES
First Claim
1. Injectable polymeric particles comprising a copolymer that comprises(a) a hydroxy-acid-based repeat unit selected from a mono(hydroxy acid) unit and a poly(hydroxy acid) unit,(b) an alkyl-ether-based repeat unit selected from a mono(alkyl ether) unit and a poly(alkyl ether) unit, and(c) an acid-based repeat unit selected from a unit comprising multiple carboxylic acid groups, a unit comprising multiple acid chloride groups, and a cyclic acid anhydride unit, wherein 95 vol % of the particles have a longest linear cross-sectional dimension between 40 μ
- m and 5000 μ
m.
0 Assignments
0 Petitions
Accused Products
Abstract
According to an aspect of the invention, injectable polymeric particles are provided that contain a copolymer that contains a hydroxy-acid-based repeat unit selected from a mono(hydroxy acid) unit and a poly(hydroxy acid) unit, an alkyl-ether-based repeat unit selected from a mono(alkyl ether) unit and a poly(alkyl ether) unit, and an acid-based repeat unit selected from a unit comprising multiple carboxylic acid groups and a derivative thereof Other aspects of the invention pertain to methods of making such particles. Still other aspects of the invention pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions.
72 Citations
25 Claims
-
1. Injectable polymeric particles comprising a copolymer that comprises
(a) a hydroxy-acid-based repeat unit selected from a mono(hydroxy acid) unit and a poly(hydroxy acid) unit, (b) an alkyl-ether-based repeat unit selected from a mono(alkyl ether) unit and a poly(alkyl ether) unit, and (c) an acid-based repeat unit selected from a unit comprising multiple carboxylic acid groups, a unit comprising multiple acid chloride groups, and a cyclic acid anhydride unit, wherein 95 vol % of the particles have a longest linear cross-sectional dimension between 40 μ
Specification