Method for the Production of Polymerized Nanoparticles and Microparticles by Ternary Agent Concentration and Temperature Alteration Induced Immiscibility

• US 20090117189A1
• Filed: 01/09/2009
• Published: 05/07/2009
• Est. Priority Date: 09/15/2004
• Status: Abandoned Application

• Current Assignee: Adrian T. Raiche, Jeffrey G. Linhardt, Joseph C. Salamone
• Original Assignee: Adrian T. Raiche, Jeffrey G. Linhardt, Joseph C. Salamone
• Inventors: Linhardt, Jeffrey G., Salamone, Joseph C., Raiche, Adrian T.
• Application Number:
  US12/351,222
• Publication Number:
  US 20090117189A1
• Time in Patent Office: Days
• US Class Current: 514/1.100
• CPC Class Codes: A61K 9/1682 Processes
• CPC Class Codes: A61K 9/5089 Processes
• CPC Class Codes: C08F 2/22 Emulsion polymerisation

Abstract

Polymerized drug delivery devices are described. Additionally, methods are described for producing and for using polymerized particles for use as drug delivery devices.

Claims

1-3. -3. (canceled)

4. A method for the production of a drug delivery system comprising:

combining;

(a) a non-solvent;

(b) a ternary agent;

(c) a surfactant;

(d) a monomer, a macromonomer, or a combination thereof; and

(e) an initiator, to produce a non-solvent solution;

combining;

(a) a solvent that is miscible with said non-solvent; and

(b) a polymer, a matrix material, or a combination thereof that is miscible in said solvent, to produce a solvent solution;

combining;

(a) an agent solvent; and

(b) a therapeutically active agent, to produce an agent solution, wherein said agent solvent is miscible in said non-solvent, is not a good solvent for said ternary agent, and has a temperature-dependent miscibility in said non-solvent solution;

combining said non-solvent solution, said solvent solution and said agent solution to produce a mixture;

changing a temperature of said mixture to produce emulsions as a result of said changing said temperature, said emulsions resulting in polymerized particles containing said therapeutically active agent.

5. The method of claim 4, wherein said non-solvent comprises water;

said ternary agent comprises sodium chloride or sodium bromide;

said surfactant is selected from the group consisting of poly(N-vinylpyrrolidone), poly(ethylene oxide)/poly(propylene oxide) triblock copolymers, Tweens, Sorbitans, and triacyl glycerols;

said solvent comprises acetone or acetonitrile solvent;

said polymer comprises polyurethane or polysaccharide;

said matrix material comprises trehalose, dextrose or triethanolamine; and

said agent solvent comprises ethyl acetate.

31. The method of claim 4 or 5, wherein said therapeutically active agent is selected from the group consisting of beta-blockers, anti-glaucoma agents, anti-cataract agents, anti-diabetic retinopathy agents, anti-cancer agents, anti-clotting agents, anti-tissue damage agents, proteins, nucleic acids, steroids, non-steroidal anti-inflammatory agents, antibiotics, anti-pathogens, anti-viral agents, cycloplegic agents, mydriatic agents, anticholinergics, anticoagulants, antifibrinolytics, antihistamines, antimalarials, antitoxins, chelating agents, hormones, immunosuppressives, thrombolytics, vitamins, salts, desensitizers, prostaglandins, amino acids, metabolites and antiallergenics.

6-30. -30. (canceled)

32-42. -42. (canceled)