CAROTENOID-CONTAINING COMPOSITIONS AND METHODS

• US 20090118229A1
• Filed: 09/09/2008
• Published: 05/07/2009
• Est. Priority Date: 11/07/2007
• Status: Abandoned Application

• Current Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Original Assignee: Bristol-Myers Squibb Company
• Inventors: Jouni, Zeina, Makhoul, Zeina
• Application Number:
  US12/206,856
• Publication Number:
  US 20090118229A1
• Time in Patent Office: Days
• US Class Current: 514/54
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23L 33/26 Polyol polyesters, e.g. sucrose polyesters; Synthetic sugar polymers, e.g. polydextrose
• CPC Class Codes: A23L 5/44 using carotenoids or xanthophylls
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/306 having an effect on bone mass, e.g. osteoporosis prevention
• CPC Class Codes: A23V 2200/3202 Prebiotics, ingredients fermented in the gastrointestinal tract by beneficial microflora
• CPC Class Codes: A23V 2200/332 Promoters of weight control and weight loss
• CPC Class Codes: A23V 2250/1882 Polyunsaturated fatty acids
• CPC Class Codes: A23V 2250/211 Carotene, carotenoids
• CPC Class Codes: A23V 2250/213 Lycopene
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents

Abstract

The present invention is directed to carotenoid-containing compositions and methods for improving bone or respiratory health in a subject comprising administering to the subject a combination of lycopene, beta-carotene, and beta-cryptoxanthin.

Claims

1. A nutritional composition comprising lycopene, beta-carotene, beta-cryptoxanthin, galacto-oligosaccharide, and polydextrose.

2. The nutritional composition of claim 1 wherein the nutritional composition contains each of lycopene, beta-carotene, and beta-cryptoxanthin in an amount within the range of from about 50 to about 1150 mcg/L.

3. The nutritional composition of claim 1 wherein the nutritional composition contains each of galacto-oligosaccharide and polydextrose in an amount within the range of from about 1.0 g/L to about 4.0 g/L.

4. The nutritional composition of claim 1 additionally comprising at least one long-chain polyunsaturated fatty acid selected from the group consisting of docosahexaenoic acid, arachidonic acid, eicosapentaenoic acid, and combinations thereof.

5. The nutritional composition of claim 1 wherein the nutritional composition is in a form selected from those consisting of an infant formula, human milk fortifier, and children'"'"'s nutritional product.

6. The nutritional composition of claim 1 wherein the nutritional composition is in a form selected from those consisting of powder and liquid.

7. A method for improving bone health in a subject comprising administering to the subject a combination of lycopene, beta-carotene, and beta-cryptoxanthin.

8. The method of claim 7 wherein the improvement of bone health is selected from the group consisting of an increased bone mineral content, an increased bone mineral density, a decreased risk of osteoporosis, a decrease in the formation of osteoclasts, the induction of apoptosis of osteoclasts, and increased bone formation.

9. The method of claim 8 wherein the increased bone formation occurs via a method selected from the group consisting of increased alkaline phosphatase, increased calcium absorption, increased calcium content, increased bone DNA content, increased hormones in bone formation, increased collagen, increased transcription factors involved in bone formation, and increased osteoblasts.

10. The method of claim 7 wherein the amount of lycopene administered is within the range of about 0.01 mg and about 10 mg per kg body weight per day.

11. The method of claim 7 wherein the amount of beta-carotene administered is within the range of about 0.01 mg and about 10 mg per kg body weight per day.

12. The method of claim 7 wherein the amount of beta-cryptoxanthin administered is within the range of about 0.01 mg and about 10 mg per kg body weight per day.

13. The method of claim 7 wherein the amount of lycopene administered is within the range of about 0.1 mg and about 5 mg per kg body weight per day, the amount of beta-carotene administered is within the range of about 0.1 mg and about 5 mg per kg body weight per day, and the amount of beta-cryptoxanthin administered is within the range of about 0.1 mg and about 5 mg per kg body weight per day.

14. The method of claim 7 additionally comprising the administration of at least one LCPUFA selected from the group consisting of DHA, ARA, EPA, and combinations thereof.

15. The method of claim 7 additionally comprising the administration of galacto-oligosaccharide and polydextrose.

16. The method of claim 7 wherein the lycopene, beta-carotene, and beta-cryptoxanthin are administered in the form of an infant formula.

17. A method for improving respiratory health in a subject comprising administering to the subject a combination of lycopene, beta-carotene, and beta-cryptoxanthin.

18. The method of claim 17 wherein the improvement in respiratory health comprises one or more selected from the group consisting of oxygen diffusivity in the blood or lungs, reduced local hypoxia at the blood-tissue interface of blood vessel walls, increased FEV1, increased FVC, and decreased decline in FEV1.

19. The method of claim 17, wherein the improvement in respiratory health comprises reducing or preventing asthma.

20. A method for preventing obesity in a subject comprising administering to the subject a combination of tycopene, beta-carotene, and beta-cryptoxanthin.