Injectable capsaicin with non-steroidal anti-inflammatory adjunctive agent
First Claim
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1. A method for relieving pain at a site in a human or animal in need thereof, comprising:
- administering at a discrete painful site in a human or animal in need thereof a single injectable or implantable dose of a capsaicinoid in an amount effective to denervate said discrete site without eliciting an effect outside the discrete location and to attenuate pain emanating from said site, said effective dose being from about 1 mcg to about 5000 mcg of capsaicin or a therapeutically equivalent dose of a capsaicinoid other than capsaicin; and
coadministering an effective amount of a non-steroidal anti-inflammatory agent to decrease an undesired effect of the capsaicinoid.
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Abstract
Disclosed in certain embodiments is a method for relieving pain at a site in a human or animal in need thereof, comprising administering by injection or infiltration, a dose of a capsaicinoid and coadministering an effective amount of a NSAID to decrease an undesired effect of the capsaicinoid.
28 Citations
21 Claims
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1. A method for relieving pain at a site in a human or animal in need thereof, comprising:
- administering at a discrete painful site in a human or animal in need thereof a single injectable or implantable dose of a capsaicinoid in an amount effective to denervate said discrete site without eliciting an effect outside the discrete location and to attenuate pain emanating from said site, said effective dose being from about 1 mcg to about 5000 mcg of capsaicin or a therapeutically equivalent dose of a capsaicinoid other than capsaicin; and
coadministering an effective amount of a non-steroidal anti-inflammatory agent to decrease an undesired effect of the capsaicinoid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- administering at a discrete painful site in a human or animal in need thereof a single injectable or implantable dose of a capsaicinoid in an amount effective to denervate said discrete site without eliciting an effect outside the discrete location and to attenuate pain emanating from said site, said effective dose being from about 1 mcg to about 5000 mcg of capsaicin or a therapeutically equivalent dose of a capsaicinoid other than capsaicin; and
- 18. An injectable or implantable pharmaceutical composition for attenuating pain at a site in a human or animal in need thereof, comprising from 1 mcg to 5000 mcg of a capsaicinoid, an effective amount of an NSAID to decrease an undesired effect of the capsaicinoid, and a pharmaceutically acceptable vehicle for injection or implantation.
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21-40. -40. (canceled)
Specification