Non-Aqueous Water-Miscible Materials as Vehicles for Drug Delivery
First Claim
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1. A method of preparing a pharmaceutical composition comprising the steps of:
- a) providing a non-aqueous water-miscible material;
b) solubilizing in the non-aqueous water-miscible material a pharmaceutical component having a low aqueous solubility,wherein the pharmaceutical component is solubilizable in the non-aqueous water-miscible material in an amount sufficient to obtain a therapeutically effective concentration of the pharmaceutical composition; and
wherein the non-aqueous water-miscible material is present in the composition in an amount sufficient to deliver a therapeutically effective amount of the pharmaceutical component when the composition is administered into a target tissue.
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Abstract
A pharmaceutical composition includes at least one pharmaceutical component having a low aqueous solubility and at least one non-aqueous water-miscible material. Such a pharmaceutical composition is useful in providing a therapeutically meaningful amount of such pharmaceutical component at a target tissue. The pharmaceutical composition is particularly suitable for administration to or into an ocular environment to treat or control an ocular disease, disorder, or condition.
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Citations
20 Claims
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1. A method of preparing a pharmaceutical composition comprising the steps of:
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a) providing a non-aqueous water-miscible material; b) solubilizing in the non-aqueous water-miscible material a pharmaceutical component having a low aqueous solubility, wherein the pharmaceutical component is solubilizable in the non-aqueous water-miscible material in an amount sufficient to obtain a therapeutically effective concentration of the pharmaceutical composition; and wherein the non-aqueous water-miscible material is present in the composition in an amount sufficient to deliver a therapeutically effective amount of the pharmaceutical component when the composition is administered into a target tissue. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A pharmaceutical composition comprising:
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a pharmaceutical component having a low aqueous solubility;
the pharmaceutical component being present in the composition in an amount that is therapeutically effective when the composition is administered to or into a target tissue; anda non-aqueous water-miscible material in an amount sufficient to solubilize said therapeutically effective amount of the pharmaceutical component. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method of treating or controlling an ocular disease, disorder, or condition, the method comprising:
administering to or into an ocular environment a therapeutically effective amount of a mixture comprising a pharmaceutical component having low aqueous solubility solubilized in a non-aqueous water-miscible material, to treat or control said disease, disorder, or condition. - View Dependent Claims (18, 19, 20)
Specification