Calculating Respiration Parameters Using Impedance Plethysmography
First Claim
1. A method of determining a value for a respiration parameter in a test subject, the method comprising:
- capturing—
using a fully implanted system that is comprised of a wireless transmitter and at least a first lead wire having a first electrode disposed thereon and a second lead wire having a second electrode disposed thereon, wherein the at least first and second lead wires are positioned in the test subject subcutaneously and external of any cranial, thoracic, abdominal and pelvic cavities of the test subject—
information indicative of an impedance measure between the first and second electrodes and across a thoracic region of the test subject;
wirelessly transmitting, from the implanted system and to external equipment, the captured information;
determining in the external equipment a value for a respiration parameter of the test subject based on the wirelessly transmitted information; and
using the determined respiration parameter in safety pharmacology testing or toxicity testing to assess impact of a pharmaceutical compound on the test subject'"'"'s respiratory system.
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Accused Products
Abstract
A method of determining a value for a respiration parameter in a test subject can include capturing—using a fully implanted system that includes a wireless transmitter and at least a first lead wire having a first electrode disposed thereon and a second lead wire having a second electrode disposed thereon—information indicative of an impedance measure between the first and second electrodes and across a thoracic region of the test subject; wirelessly transmitting, from the implanted system and to external equipment, the captured information; and determining a respiration parameter of the test subject based on the captured information. The at least first and second lead wires can be positioned in the test subject subcutaneously and external of any cranial, thoracic, abdominal and pelvic cavities of the test subject
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Citations
25 Claims
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1. A method of determining a value for a respiration parameter in a test subject, the method comprising:
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capturing—
using a fully implanted system that is comprised of a wireless transmitter and at least a first lead wire having a first electrode disposed thereon and a second lead wire having a second electrode disposed thereon, wherein the at least first and second lead wires are positioned in the test subject subcutaneously and external of any cranial, thoracic, abdominal and pelvic cavities of the test subject—
information indicative of an impedance measure between the first and second electrodes and across a thoracic region of the test subject;wirelessly transmitting, from the implanted system and to external equipment, the captured information; determining in the external equipment a value for a respiration parameter of the test subject based on the wirelessly transmitted information; and using the determined respiration parameter in safety pharmacology testing or toxicity testing to assess impact of a pharmaceutical compound on the test subject'"'"'s respiratory system.
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2. A method of determining a value for a respiration parameter in a test subject, the method comprising:
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capturing—
using a fully implanted system that is comprised of a wireless transmitter and at least a first lead wire having a first electrode disposed thereon and a second lead wire having a second electrode disposed thereon, wherein the at least first and second lead wires are positioned in the test subject subcutaneously and external of any cranial, thoracic, abdominal and pelvic cavities of the test subject—
information indicative of an impedance measure between the first and second electrodes and across a thoracic region of the test subject;wirelessly transmitting, from the implanted system and to external equipment, the captured information; and determining a respiration parameter of the test subject based on the captured information. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. An implantable device configured to monitor thoracic impedance in a test subject, the implantable device comprising:
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a fully implantable system that is comprised of controller and at least a first lead wire and a second lead wire, wherein the controller and the first and second lead wires are configured to be subcutaneously implanted in the test subject, external of any cranial, thoracic, abdominal or pelvic cavities of the test subject; wherein, the first lead wire has first and second electrodes disposed thereon and the second lead wire has third and fourth electrodes disposed thereon; and wherein the controller comprises a) a current signal generator that generates a current signal between the first and third electrodes;
b) a voltage amplifier that detects a voltage difference between the second and fourth electrodes; and
c) a wireless transmitter that is configured to transmit information to external equipment when the test subject is ambulatory and unanesthetized, the information comprising the detected voltage difference or a signal derived from the detected voltage difference.
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Specification