METHODS FOR MEASURING CROSS-SECTIONAL AREAS AND PRESSURE GRADIENTS IN LUMINAL ORGANS
First Claim
1. A method for measuring the cross-sectional area of a targeted treatment site, comprising:
- introducing an impedance catheter into a treatment site;
providing electrical current flow to the treatment site through the catheter;
injecting a known volume of a first solution of a first compound having a first conductivity into the treatment site;
measuring a first conductance value at the treatment site;
injecting a second solution of a second compound having a second conductivity into the treatment site, wherein the second solution has a second volume and wherein the second conductivity does not equal the first conductivity;
measuring a second conductance value at the treatment site; and
calculating the cross-sectional area of the treatment site based on the first and second conductance values and the conductivities of the first and second solutions.
1 Assignment
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Accused Products
Abstract
The present disclosure comprises a system, catheter and method for measuring the cross-sectional areas and pressure gradients in any hollow organ, such as, for example, blood vessels. One embodiment of such a method includes the steps of introducing an impedance catheter into a treatment site, providing electrical current flow to the treatment site, injecting a first solution and measuring a first conductance value, injecting a second solution and measuring a second conductance value, and calculating the cross-sectional area of the treatment site, in part, based on the first and second conductance values.
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Citations
30 Claims
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1. A method for measuring the cross-sectional area of a targeted treatment site, comprising:
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introducing an impedance catheter into a treatment site; providing electrical current flow to the treatment site through the catheter; injecting a known volume of a first solution of a first compound having a first conductivity into the treatment site; measuring a first conductance value at the treatment site; injecting a second solution of a second compound having a second conductivity into the treatment site, wherein the second solution has a second volume and wherein the second conductivity does not equal the first conductivity; measuring a second conductance value at the treatment site; and calculating the cross-sectional area of the treatment site based on the first and second conductance values and the conductivities of the first and second solutions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method for measuring the cross-sectional area of a targeted treatment site, comprising:
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introducing a first catheter into a treatment site; providing electrical current flow to the treatment site through the catheter; injecting a known volume of a first solution of a first compound having a first conductivity into the treatment site; measuring a first conductance value at the treatment site; injecting a second solution of a second compound having a second conductivity into the treatment site, wherein the second solution has a second volume and wherein the second conductivity does not equal the first conductivity; measuring a second conductance value at the treatment site; calculating the cross-sectional area of the treatment site based on the first and second conductance values and the conductivities of the first and second solutions; and selecting a second catheter to be introduced into the treatment site based on the measurement of a first conductance and a first current density at the treatment site. - View Dependent Claims (28)
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29. A method for measuring the cross-sectional area of a targeted treatment site, comprising:
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introducing an impedance catheter into a treatment site; providing electrical current flow to the treatment site through the catheter; injecting a first solution having a first conductivity into the treatment site; measuring a first conductance value at the treatment site; injecting a second solution having a second conductivity into the treatment site, wherein the second conductivity does not equal the first conductivity; measuring a second conductance value at the treatment site; calculating the cross-sectional area of the treatment site based on the first and second conductance values and the conductivities of the first and second solutions; selecting an appropriately-sized stent based on the cross-sectional area value of the treatment site; positioning the stent around a balloon attached to the catheter; introducing the catheter with the stent positioned thereon into the treatment site; inflating the balloon with a fluid to implant the stent into the treatment site; providing electrical current into the fluid filling the balloon at various degrees of balloon distension; measuring the conductance of the fluid inside the balloon; and calculating the cross-sectional area of the balloon lumen.
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30. A method for measuring the cross-sectional area of a blood vessel, comprising:
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introducing an impedance catheter into a blood vessel; providing electrical current flow through the catheter within the blood vessel; injecting a known volume of a first solution of a first compound having a first conductivity into the blood vessel; measuring a first conductance value within the blood vessel at or near the site of injection of the first solution; injecting a second solution of a second compound having a second conductivity into the blood vessel, wherein the second solution has a second volume and wherein the second conductivity does not equal the first conductivity; measuring a second conductance value within the blood vessel at or near the site of the injection of the second solution; calculating the cross-sectional area of the blood vessel based on the first and second conductance values and the conductivities of the first and second solutions; selecting an selecting an appropriately-sized stent based on the cross-sectional area of the blood vessel; and implanting the stent into the blood vessel.
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Specification