CLOSED LOOP ANESTHETIC DELIVERY

• US 20090118697A1
• Filed: 01/07/2009
• Published: 05/07/2009
• Est. Priority Date: 07/07/2004
• Status: Abandoned Application

• Current Assignee: Ethicon Endo-Surgery, Inc. (Johnson & Johnson)
• Original Assignee: Ethicon Endo-Surgery, Inc. (Johnson & Johnson)
• Inventors: Martin, James F.
• Application Number:
  US12/349,872
• Publication Number:
  US 20090118697A1
• Time in Patent Office: Days
• US Class Current: 604/503
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/486 Bio-feedback A61B5/375 takes precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A method for delivering a sedation drug comprising administering a drug to a patient while requesting the patient to respond to an instruction, monitoring a patient'"'"'s BIS values, bringing the patient to a level of anesthesia where the patient fails to respond to the request within a predetermined response time, and determining a BIS value that coincides with the level of anesthesia corresponding to the failure to respond.

Claims

1. A method for delivering a sedation drug comprising the steps of:

providing at least one device for infusing a sedation drug and for measuring a patient'"'"'s index of depth of anesthesia;

initially administering a sedation drug to a patient in an open loop mode while requesting the patient to respond to an instruction;

monitoring a patient'"'"'s index of depth of anesthesia;

bringing the patient to a level of anesthesia where the patient fails to respond to the request within a predetermined response time;

determining an index of depth of anesthesia value that coincides with the level of anesthesia where the patient fails to respond; and

adjusting the administration of the sedation drug to the patient to a closed loop mode.

2. The method of claim 1 wherein the request is generated by an automated response monitoring system (ARM).

3. The method of claim 2 wherein the patient is brought to a level of anesthesia at which the patient does not respond to ARM.

4. The method of claim 3 wherein ARM includes:

a controller which generates a request for a predetermined response from the patient and which analyses a response generated by the patient to the request for a predetermined response; and

a response testing apparatus including;

a request assembly which communicates to the patient the request generated by the controller; and

a response assembly which is used by the patient to generate the response and which communicates the response to the controller,

wherein at least one of the request assembly and the response assembly communicates at least one of the request and the response between the controller and the patient.

5. The method of claim 2 further comprising the step of establishing the index of depth of anesthesia value that coincides with the level of anesthesia where the patient fails to respond as an index of depth of anesthesia setpoint and continuing to administer the drug to the patient while monitoring the patient'"'"'s index of depth of anesthesia values relative to the index of depth of anesthesia setpoint.

6. The method of claim 5 further comprising the step of changing a patient'"'"'s level of anesthesia by changing the index of depth of anesthesia setpoint relative to the index of depth of anesthesia value that coincides with the level of anesthesia where the patient fails to respond.

7. The method of claim 1 wherein the step of initially administering the drug to the patient includes infusing the drug with an infusion rate profile in which the infusion rate is gradually increasing.

8. The method of claim 1 wherein the step of initially administering the drug to the patient includes infusing the drug with an infusion rate profile in which the infusion rate is gradually decreasing.

9. The method of claim 1 wherein the step of initially administering the drug to the patient includes infusing the drug with an infusion rate profile in which the infusion rate is constant.

10. The method of claim 1 wherein the step of initially administering the drug to the patient includes infusing the drug with an infusion rate profile in which the infusion rate increases at a constant rate.

11. The method of claim 1 wherein the step of initially administering the drug to the patient includes infusing the drug with an infusion rate profile in which the infusion rate increases at a non-constant rate.

12. The method of claim 6 wherein the step of continuing to administer the drug is adjusted based on a difference between the patient'"'"'s index of depth of anesthesia value and the index of depth of anesthesia setpoint.

13. The method of claim 5 wherein the step of continuing to administer the drug is conducted in a closed loop with the step of monitoring the patient'"'"'s index of depth of anesthesia values relative to the index of depth of anesthesia setpoint.

14. The method of claim 1 wherein said index of depth of anesthesia is the Bispectral Index.

15. The method of claim 1 wherein said index of depth of anesthesia is based on audio evoked potential.

16. The method of claim 1 wherein said index of depth of anesthesia is Narcotrend.