ISOLATION OF PRECURSOR CELLS AND THEIR USE FOR TISSUE REPAIR
First Claim
1. A method of positively identifying viable, expanded or passaged, committed, pluripotent skeletal precursor cells that have entered a post-natal differentiation pathway leading to skeletal or connective tissues comprising the steps of isolating mammalian cells into a cell culture in vitro, and detecting the expression by said cells of a positive embryonic marker which is cartilage-derived morphogenic protein CDMP-1.
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Accused Products
Abstract
Cartilage-derived morphogenetic protein CDMP-1 or a transforming growth factor β having at least 80% homology with CDMP-1, or a factor co-expressed and/or co-detectable therewith, is used as a marker of skeletal precursor cells from any part of a mammalian body.
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Citations
7 Claims
- 1. A method of positively identifying viable, expanded or passaged, committed, pluripotent skeletal precursor cells that have entered a post-natal differentiation pathway leading to skeletal or connective tissues comprising the steps of isolating mammalian cells into a cell culture in vitro, and detecting the expression by said cells of a positive embryonic marker which is cartilage-derived morphogenic protein CDMP-1.
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7. A method for obtaining a homogenous culture of viable, expanded or passaged, committed, pluripotent skeletal precursor cells that have entered a post-natal differentiation pathway leading to skeletal or connective tissues comprising the steps of isolating mammalian cells into a cell culture in vitro, and determining the expression by said culture of a positive embryonic marker which is cartilage-derived morphogenic protein CDMP-1.
Specification