Compositions of aminoacyl-tRNA synthetase and uses thereof
First Claim
Patent Images
1. A composition comprising an aminoacyl tRNA synthetase (RS) having the nucleic acid sequence selected from the group consisting of SEQ ID NO:
- 4, a polynucleotide sequence encoding the amino acid sequence of SEQ ID NO;
5, a polynucleotide sequence encoding the amino acid sequence of SEQ ID NO;
17, a complementary polynucleotide sequence thereof, and a conservative variation thereof.
1 Assignment
0 Petitions
Accused Products
Abstract
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA'"'"'s, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA'"'"'s/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
-
Citations
45 Claims
-
1. A composition comprising an aminoacyl tRNA synthetase (RS) having the nucleic acid sequence selected from the group consisting of SEQ ID NO:
- 4, a polynucleotide sequence encoding the amino acid sequence of SEQ ID NO;
5, a polynucleotide sequence encoding the amino acid sequence of SEQ ID NO;
17, a complementary polynucleotide sequence thereof, and a conservative variation thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 40, 41, 42, 43, 44)
- 4, a polynucleotide sequence encoding the amino acid sequence of SEQ ID NO;
-
36. A vector comprising a polynucleotide encoding an RS having the nucleic acid sequence selected from the group consisting of SEQ ID NO:
- 4, a polynucleotide sequence encoding the amino acid sequence of SEQ ID NO;
5, a polynucleotide sequence encoding the amino acid sequence of SEQ ID NO;
17, a complementary polynucleotide sequence thereof, and a conservative variation thereof. - View Dependent Claims (37, 38, 39)
- 4, a polynucleotide sequence encoding the amino acid sequence of SEQ ID NO;
-
45. A polynucleotide having a nucleic acid sequence selected from a group consisting of SEQ ID No. 4, a polynucleotide sequence encoding the amino acid sequence of SEQ ID NO:
- 5, a polynucleotide sequence encoding the amino acid sequence of SEQ ID NO;
17, a complementary polynucleotide sequence thereof, and a conservative variation thereof.
- 5, a polynucleotide sequence encoding the amino acid sequence of SEQ ID NO;
Specification