Nanowire-based sensor configurations
First Claim
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1. A method of detecting an analyte of interest, comprising:
- providing a nanowire having a sample exposure region, the sample exposure region comprising at least one binding molecule for an analyte of interest disposed thereon, the nanowire being operably coupled to an electrical parameter detector;
contacting the sample exposure region with a sample material suspected of containing the analyte of interest for a first period of time to allow any analyte of interest in the sample material to associate with the sample exposure region of the nanowire;
treating the nanowire to rapidly remove at least a portion of the analyte of interest from the sample exposure region; and
monitoring the electrical parameter of the nanowire during at least the treating step to detect a change in the electrical parameter in response to the treating step, the change in the electrical parameter being indicative of a presence or amount of analyte of interest bound to the sample exposure region from the sample material.
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Abstract
This invention provides nanowire based molecular sensors and methods for detecting analytes in a microfluidic system. Methods for sensing analytes include detecting changed electrical parameters associated with contact of a nanowire with the analyte in a microfluidic system. Sensors of the invention include nanowires mounted in microchambers of a microfluidic system in electrical contact with the detector, whereby electrical parameter changes induced in the nanowire by the analyte can be monitored by the detector.
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Citations
13 Claims
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1. A method of detecting an analyte of interest, comprising:
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providing a nanowire having a sample exposure region, the sample exposure region comprising at least one binding molecule for an analyte of interest disposed thereon, the nanowire being operably coupled to an electrical parameter detector; contacting the sample exposure region with a sample material suspected of containing the analyte of interest for a first period of time to allow any analyte of interest in the sample material to associate with the sample exposure region of the nanowire; treating the nanowire to rapidly remove at least a portion of the analyte of interest from the sample exposure region; and monitoring the electrical parameter of the nanowire during at least the treating step to detect a change in the electrical parameter in response to the treating step, the change in the electrical parameter being indicative of a presence or amount of analyte of interest bound to the sample exposure region from the sample material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification