Novel Crystalline Pharmaceutical Product
First Claim
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1. Crystalline particles of unsolvated Form 1 polymorph of the compound of formula (I):
- characterised in that the particles are in the form of substantially triangular plates.
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Abstract
There are provided crystalline particles of unsolvated Form 1 polymorph of the compound of formula (I):
characterised in that the particles are in the form of substantially triangular plates.
75 Citations
19 Claims
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1. Crystalline particles of unsolvated Form 1 polymorph of the compound of formula (I):
characterised in that the particles are in the form of substantially triangular plates. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 18)
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10. A process for preparing crystalline particles of unsolvated Form 1 polymorph of the compound of formula (I):
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wherein the particles are in the form of substantially triangular plates, which process comprises dissolving the compound of formula (I) in a solvent of methyl-isobutyl-ketone (MIBK) containing between 1 and 15% v/v methyl-ethyl-ketone (MEK), and producing compound of formula (I) as unsolvated Form 1 polymorph by addition of heptane as anti-solvent. - View Dependent Claims (11, 12, 13, 14, 15)
obtainable by the process of claim 14.
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16-17. -17. (canceled)
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19. An apparatus adapted to prepare crystalline particles of a substance which comprises:
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(i) a first reservoir adapted to contain said substance dissolved in a liquid solvent; (ii) a second reservoir adapted to contain liquid anti-solvent for said substance which is miscible with the liquid solvent; (iii) a first mixing chamber having first and second inlet ports, an outlet port and a source of ultrasonic radiation; (iv) a second mixing chamber having a first inlet port adapted for fluid connection with the outlet port of the first mixing chamber such that liquid exiting the first mixing chamber flows into the second mixing chamber, a second inlet port adapted for fluid connection with the antisolvent reservoir, an outlet port and a source of ultrasonic radiation; (v) means for delivering the contents of the first reservoir to the first mixing chamber via the first inlet port, and means for delivering the contents of the second reservoir to the first and second mixing chambers via the second inlet ports; and (vi) means for collecting particles suspended in the liquid discharged from the outlet port of the second mixing chamber.
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Specification