METHOD AND DEVICE TO ADMINISTER ANESTHETIC AND OR VOSACTIVE AGENTS ACCORDING TO NON-INVASIVELY MONITORED CARDIAC AND OR NEUROLOGICAL PARAMETERS
First Claim
1. A method of administering a general anesthetic, comprising the steps of:
- non-invasively measuring a set of predetermined non-invasive cardiac and neurological parameters from a subject;
converting the non-invasive cardiac parameters into a plurality of invasive cardiac analogues based upon a first set of predetermined conversion equations;
converting the non-invasive neurological parameters into a neurological index based upon a second set of predetermined conversion equations;
administering a general anesthetic based upon neurological index to maintain a desirable level of neurological depression in the subject; and
independently administering a vasoactive agent based upon the converted invasive cardiac analogues to restore cardiovascular homeostasis in the subject.
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Accused Products
Abstract
A method of and a device for non-invasively measuring the neurological depressed state and the hemodynamic state of a human patient and involving steps and units of non-invasively measuring EEG, cardiac cycle period, electrical-mechanical interval, mean arterial pressure, and ejection interval and converting the EEG into a neurological index as well as converting the measured electrical-mechanical interval, mean arterial pressure and ejection interval into the cardiac parameters such as Preload, Afterload and Contractility, which are the common cardiac parameters used by an anesthesiologist. A general anesthetic is administered based upon the converted neurological index. A vasoactive agent is independently administered based upon the converted cardiac parameters as necessary in order to restore cardiovascular homeostasis in the patient. The converted neurological and hemodynamic state of a patient are displayed on a screen as an index value and a three-dimensional vector with each of its three coordinates respectively representing Preload, Afterload and Contractility. Therefore, a medical practitioner looks at the screen and quickly obtains the important and necessary information.
114 Citations
138 Claims
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1. A method of administering a general anesthetic, comprising the steps of:
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non-invasively measuring a set of predetermined non-invasive cardiac and neurological parameters from a subject; converting the non-invasive cardiac parameters into a plurality of invasive cardiac analogues based upon a first set of predetermined conversion equations; converting the non-invasive neurological parameters into a neurological index based upon a second set of predetermined conversion equations; administering a general anesthetic based upon neurological index to maintain a desirable level of neurological depression in the subject; and independently administering a vasoactive agent based upon the converted invasive cardiac analogues to restore cardiovascular homeostasis in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 137, 138)
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50. A system for administering a general anesthetic, comprising:
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a non-invasive neurological parameter measuring unit for non-invasively measuring at least a predetermined neurological parameter from the subject; a neurological parameter conversion unit connected to said non-invasive neurological parameter measuring unit for converting the non-invasive neurological parameter into a neurological index based upon a first set of predetermined conversion equations; a general anesthetic administering unit connected to said neurological parameter conversion unit for administering a general anesthetic based upon the neurological index to maintain a desirable level of neurological depression in the subject; a non-invasive cardiac parameter measuring unit for non-invasively measuring a plurality of predetermined non-invasive cardiac parameters from the subject; a cardiac parameter conversion unit connected to said non-invasive cardiac parameter measuring unit for converting the non-invasive cardiac parameters into a plurality of invasive cardiac analogues based upon a second set of predetermined conversion equations; and a vasoactive agent administering unit connected to said cardiac parameter conversion unit for administering a vasoactive agent based upon the invasive cardiac analogues to restore cardiovascular homeostasis in the subject. - View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110)
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111. A method of performing equipotency assays on anesthetizing agents, comprising the steps of:
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a) anesthetizing a subject with a first anesthetizing agent to a certain predetermined level; b) maintaining a level of neurological depression by a predetermined procedure; c) monitoring a cardiovascular state of the patient; d) achieving cardiovascular equilibrium in the cardiovascular state; e) assaying a concentration of the first anesthetizing agent in blood of the patient; and f) repeating the above steps a) through e) with a second anesthetizing agent with the same subject to determine whether or not the first anesthetizing agent and second anesthetizing agent achieve a substantially identical hemodynamic state. - View Dependent Claims (112, 113, 114, 115, 116)
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117. A system for performing equipotency assays on anesthetizing agents, comprising:
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a general anesthetic administering unit for anesthetizing a subject separately with a first anesthetizing agent and a second anesthetizing agent to a certain predetermined level; a non-invasive neurological parameter measuring unit connected to said general anesthetic administering unit for non-invasively measuring at least a predetermined neurological parameter from the subject, wherein said general anesthetic administering unit maintains a level of neurological depression by a predetermined procedure; a non-invasive cardiac parameter measuring unit for non-invasively measuring cardiac parameters and monitoring a cardiovascular state of the patient; a vasoactive agent administering unit connected to said non-invasive cardiac parameter measuring unit for achieving cardiovascular equilibrium; and a central monitoring and delivering unit for recording respective concentrations of the first anesthetizing agent and the second anesthetizing agent in blood of the patient and for determining whether or not the first anesthetizing agent and second anesthetizing agent achieve a substantially identical hemodynamic state. - View Dependent Claims (118, 119, 120, 121, 122)
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123. A method of simulating cardiovascular and neurological conditions of a patient under a general anesthetic, comprising the steps of:
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inputting first data representing characteristics of a patient; inputting second data representing an anesthetic agent; simulating neurological conditions and cardiovascular conditions in response the second data based upon the first data; displaying information representing at least some of the simulated neurological conditions and the simulated cardiovascular conditions; audio-visually warning any undesirable condition; and allowing human intervention if the undesirable condition exists. - View Dependent Claims (124, 125, 126, 127, 128, 129)
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130. A system for simulating cardiovascular and neurological conditions of a patient under a general anesthetic, comprising:
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a patient characteristic database for storing first data representing characteristics of a patient and second data representing an anesthetic agent; a simulation module connected to said patient characteristic database for inputting the first data and the second data, said simulation module simulating neurological conditions and cardiovascular, conditions in response the second data based upon the first data; and a display unit connected to said simulation module for displaying information representing at least some of the simulated neurological conditions and the simulated cardiovascular conditions, said display unit audio-visually warning any undesirable condition and allowing to receive an input indicative of human intervention if the undesirable condition exists. - View Dependent Claims (131, 132, 133, 134, 135, 136)
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Specification