MINIATURE DRUG DELIVERY PUMP WITH A PIEZOELECTRIC DRIVE SYSTEM

• US 20090124994A1
• Filed: 11/08/2007
• Published: 05/14/2009
• Est. Priority Date: 11/08/2007
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Roe, Steven N.
• Granted Patent: US 7,592,740 B2
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A61M 2005/14573 with a replaceable reservoir for quick connection/disconnection with a driving system
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: F04B 43/095 Piezoelectric drive
• CPC Class Codes: H02N 2/101 using intermittent driving, e.g. step motors

Abstract

A drug delivery pump which uses a piezoelectric drive system to advance a small syringe piston to deliver a liquid drug and a method thereof are disclosed. The present invention has a cost and size advantage compared to traditional pumps and is a very compact and potentially disposable pump device design.

Claims

1. A drive system comprising:

a lead screw having a rotational axis;

a shaft extending along the rotational axis and configured to rotate the lead screw about the rotational axis;

a piezoelectric bender configured to produce reciprocating lateral motion adjacent the rotational axis; and

a clutch coupled to the shaft and configured to rotate about the rotational axis and operably connected to the piezoelectric bender, wherein the clutch is arranged to convert the reciprocating lateral motion of the piezoelectric bender into reciprocating rotary motion about the rotational axis, and wherein the clutch in only one direction turns the shaft which advances the lead screw.

2. The drive system according to claim 1, wherein the shaft has a nut portion which engages threads of the lead screw.

3. The drive system according to claim 1, wherein the shaft provides a cavity into which the lead screw is slidably accommodated.

4. The drive system according to claim 1, wherein the shaft provides a cavity into which the lead screw is slidably accommodated, and has a mating nut portion at the open end to provided advancement of the lead screw.

5. The drive system according to claim 1, wherein the shaft provides a cavity into which the lead screw is slidably accommodated, and has a detent or shaped portion acting as a key-way connection provided inside the cavity which rides in a longitudinally extending slot provided in the lead screw, and said drive system further comprises a release button having threads arranged to engage under spring tension with the lead screw such that as the shaft is rotated the lead screw advances slidably out of the cavity, and to disengage the threads with the lead screw when the release button is pushed.

6. The drive system according to claim 1 wherein the shaft provides a cavity into which the lead screw is slidably accommodated, and a biasing member provided in the cavity and configured to urge the lead screw from the cavity.

7. The drive system according to claim 1 wherein the piezoelectric bender extends longitudinally perpendicular to the rotational axis and is connected directly to a wheel mounted to the clutch.

8. The drive system according to claim 7 wherein the piezoelectric bender extends longitudinally parallel to the rotational axis and is connected to the wheel via an extension having a first portion surrounding an end of the piezoelectric bender and a second portion provided a distance from the first portion which is coupled to the wheel.

9. The drive system according to claim 7 wherein the piezoelectric bender extends longitudinally parallel to the rotational axis and is connected to the wheel via a wire wrapped at least partially around the wheel, wherein the wire is tensioned around the wheel via a spring.

10. The drive system according to claim 1 wherein the piezoelectric bender comprises a bi- morph piezoelectric crystal structure.

12. The drive system according to claim 1 further comprising a battery to power the drive system.

13. The drive system according to claim 1 provided in a drug delivery pump having a drug container, wherein the lead screw has a snap-in connection to a piston of the drug container.

14. The drive system according to claim 1 provided in a drug delivery pump having a drug container, wherein the lead screw has a snap-in connection to a piston of the drug container, and the drug delivery pump is about 61 mm long, about 32 mm wide, and 15.5 mm in height, and the drug container holds 2 ml of a liquid drug.

15. The drive system according to claim 5 provided in a drug delivery pump having a drug container, wherein the lead screw has a snap-in connection to a piston of the drug container, and wherein the detent or shaped portion has a round bearing end to minimize friction due to the inherent thrust loads encountered in operation of the lead screw pushing the piston forward.

11. The drive system according to claim 11 wherein the bi-morph piezoelectric crystal structure is a laminate piezoelectric crystal stack.

16. A method for dispensing a liquid drug from a drug container having a piston, said method comprising:

providing a lead screw connected to the piston of the drug container, the lead screw having a rotational axis;

providing a shaft extending along the rotational axis and configured to rotate the lead screw about the rotational axis;

providing a piezoelectric bender configured to produce reciprocating lateral motion adjacent the rotational axis;

providing a clutch coupled to the shaft and configured to rotate about the rotational axis; and

providing a wheel mounted to the clutch and operably connected to the piezoelectric bender, wherein the wheel converts the reciprocating lateral motion of the piezoelectric bender into reciprocating rotary motion about the rotational axis turning the clutch bi-directionally, and wherein the clutch in only one direction turns the shaft which advances the lead screw and the piston dispensing the liquid drug from the drug container.

17. The method according to claim 16 further comprises activating the piezoelectric bender which turns the lead screw in the one direction and advances the piston to dispense the liquid drug from the drug container.

18. The method according to claim 16 further comprises provided the piezoelectric bender to extend longitudinally perpendicular to the rotational axis and connecting the piezoelectric bender directly to the wheel.

19. The method according to claim 16 further comprises providing the piezoelectric bender to extend longitudinally parallel to the rotational axis and connecting the piezoelectric bender to the wheel via an extension or wire.

20. The method according to claim 16 wherein the piezoelectric bender extends longitudinally perpendicular to the rotational axis and is connected directly to the wheel, and the method further comprises activating the piezoelectric bender which turns the lead screw in the one direction and advances the piston to dispense the liquid drug from the drug container.

21. The method according to claim 16 wherein the piezoelectric bender extends longitudinally parallel to the rotational axis and is connected to the wheel via an extension, and the method further comprises activating the piezoelectric bender which turns the lead screw in the one direction and advances the piston to dispense the liquid drug from the drug container.