Biologically active metal-coated proteins
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Accused Products
Abstract
Metal-coated proteins, being dissolvable or suspendable in aqueous media and/or retaining a biological activity of the protein, a process and intermediates for preparing same are disclosed. Further disclosed are a pharmaceutical composition containing and a method of treating bacterial and fungal infections utilizing biologically active metal-coated proteins. Conductive elements, electronic circuits containing same, electrodes and biosensor systems utilizing same, and imaging probes, all containing the metal-coated proteins, are also disclosed.
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Citations
85 Claims
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1-50. -50. (canceled)
- 51. A composition-of-matter comprising a protein having a surface and a metal coating deposited over at least a portion of said surface and forming a metal-coated protein being dissolvable or suspendable in an aqueous medium, said metal being selected from the group consisting of a single metal and a combination of at least two metals, said single metal being devoid of silver, said metal coating consisting of elemental metal atoms.
- 56. A composition-of-matter comprising a protein having a surface and further having a biological activity and a metal coating deposited over at least a portion of said surface and forming a metal-coated protein retaining said biological activity, said metal being selected from the group consisting of a single metal and a combination of at least two metals, said single metal being devoid of silver, said metal coating consisting of elemental metal atoms.
- 61. A composition-of-matter comprising a protein having a modified surface and a metal coating deposited over at least a portion of said surface and forming a metal-coated protein, said modified surface having at least one chelating moiety attached thereto, said chelating moiety being for forming a complex with ions of said metal, said metal coating consisting of elemental metal atoms.
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66. A process of preparing a metal-coated protein, the process comprising:
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reacting the protein with at least one chelating moiety, to thereby obtain a modified protein having said chelating moiety attached to at least a portion of a surface thereof, said chelating moiety being for forming a complex with ions of the metal, contacting said modified protein with a first aqueous solution containing ions of said metal to thereby obtain a solution containing a complex of said modified protein and said metal ions; and contacting said solution containing said complex of said modified protein and said metal ions with a first reducing agent, said first reducing agent being for reducing said ions of said metal, thereby obtaining the metal-coated protein. - View Dependent Claims (67, 68)
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- 78. A metallic element comprising a composition-of-matter which comprises a protein having a surface and a metal coating deposited over at least a portion of said surface and forming a metal-coated protein, said metal being selected from the group consisting of a single metal and a combination of at least two metals, said single metal being devoid of silver, said metal coating consisting of elemental metal atoms.
- 82. An electrode comprising a composition-of-matter deposited thereon, said composition-of-matter comprises a protein having a surface and a metal coating deposited over at least a portion of said surface and forming a metal-coated protein, said metal being selected from the group consisting of a single metal and a combination of at least two metals, said single metal being devoid of silver, said metal coating consisting of elemental metal atoms.
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85. An imaging probe comprising a composition-of-matter which comprises a protein having a surface and a metal coating deposited over at least a portion of said surface and forming a metal-coated protein, said metal being selected from the group consisting of a single metal and a combination of at least two metals, said single metal being devoid of silver, at least one of said metals being a detectable metal, said metal coating consisting of elemental metal atoms.
Specification