Methods, products and uses involving platelets and/or the vasculature
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Abstract
The present disclosure relates to agents which interfere with the binding of GPVI to various components. Agents which interfere with GPVI interaction with one or both of fibronectin and vitronectin or sequences thereof are also disclosed. Methods of treating disorders or diseases which involve pathological, dysfunctional or non-pathological interaction of GPVI with fibronectin and/or vitronectin are included in the present disclosure. The invention also relates to uses of agents for the prevention or treatment of disorders arising from blood platelet adhesion and aggregation.
43 Citations
121 Claims
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1-88. -88. (canceled)
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89. A method for inhibiting or preventing a disorder selected from restenosis, thrombosis, atherogenesis, atheroprogession, atherosclerosis and/or vascular inflammation in a patient, the method comprising administering a therapeutically effective amount of an inhibitor of interaction between GPVI and a protein selected from vitronectin, fibronectin and combinations thereof to the patient;
- or for treating restenosis, the method comprising administering a therapeutically effective amount of a said inhibitor to a subject having restenosis or at risk of developing it.
- View Dependent Claims (90, 91, 92, 93)
- 94. An indwelling device having a coating or impregnate comprising an agent which inhibits interaction between GPVI and a protein selected from collagen, vitronectin and fibronectin, and combinations thereof.
- 103. A method of inhibiting or preventing restenosis, thrombosis, atherogenesis, atheroprogression, atherosclerosis, and/or vascular inflammation in a patient, said method comprising implanting in said patient an intravascular device comprising a direct or indirect GPVI inhibitor adapted to be exposed and/or released when the device is implanted.
- 109. A method for treating a patient suffering from, or at risk of suffering from, a disorder characterised by an interaction between GPVI and fibronectin and/or vitronectin, comprising administering an effective amount of an agent which inhibits interaction between GPVI and a protein selected from the group consisting of fibronectin, vitronectin and combinations thereof.
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113. A method for treating a patient having, or identified as having, at least one or a combination of risk factors for the formation of atherosclerotic lesions, or a patient who has been identified as having one or more risk factors associated with developing atherosclerosis, said patient having not yet developed advanced atherosclerotic plaques, wherein said patient is considered to have a risk score of 45 or greater according to the PROCAM study, the method comprising administering an effective amount of an agent which inhibits interaction between GPVI and a protein selected from the group consisting of fibronectin, vitronectin and combinations thereof.
- 114. A method for preventing or retarding atherosclerotic cardiovascular disease in a patient who is not displaying clinical symptoms of atherosclerosis, the method comprising administering to the patient an agent which inhibits binding of GPVI to a molecule selected from vitronectin, fibronectin and combinations thereof.
- 117. A method for the primary prophylaxis of atherosclerotic cardiovascular disease in a patient or for treating patient having, or identified as having, a marker of vascular inflammation, the method comprising administering to the patient an agent which inhibits binding of GPVI to a molecule selected from vitronectin, fibronectin and combinations thereof.
- 120. A method for diagnosing atherosclerotic cardiovascular disease in a patient who is not displaying clinical symptoms of atherosclerosis, the method comprising administering to the patient an agent which inhibits binding of GPVI to a molecule selected from vitronectin, fibronectin and combinations thereof and which comprises a moiety to enable visualisation or locating of the moiety in vivo.
Specification