HUMANIZED ANTIBODIES AND COMPOSITIONS FOR BINDING SPHINGOSINE-1-PHOSPHATE
First Claim
Patent Images
1. An isolated humanized antibody, or an antigen binding fragment thereof, specifically reactive with S1P and comprising at least one heavy chain and at least one light chain, wherein:
- A. each heavy chain comprises a heavy chain variable domain comprising;
(i) a sequence of amino acid residues having an amino acid sequence EVQLVQSGAEVKKPGESLKISCQSFGYIFIDHTIHWMRQMPGQGLEWM GAISPRHDITKYNEMFRGQVTISADKSSSTAYLQWSSLKASDTAMYFCA RGGFYGSTIWFDFWGQGTMVTVSS (SEQ ID NO;
32, residues 20-140, inclusive);
or(ii) a sequence of amino acid residues having at least about 80% sequence identity to the amino acid sequence of A(i), above; and
B. each light chain comprises a light chain variable domain comprising;
(i) a sequence of amino acid residues having an amino acid sequence ETTVTQSPSFLSASVGDRVTITCITTTDIDDDMNWFQQEPG KAPKLLISEGNILRPGVPSRFSSSGYGTDFTLTISKLQPEDF ATYYCLQSDNLPFTFGQGTKLEIK (SEQ ID NO;
33, residues 21-127, inclusive);
or(ii) a sequence of amino acid residues having at least about 80% sequence identity to the amino acid sequence of B(i), above.
8 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
-
Citations
16 Claims
-
1. An isolated humanized antibody, or an antigen binding fragment thereof, specifically reactive with S1P and comprising at least one heavy chain and at least one light chain, wherein:
-
A. each heavy chain comprises a heavy chain variable domain comprising; (i) a sequence of amino acid residues having an amino acid sequence EVQLVQSGAEVKKPGESLKISCQSFGYIFIDHTIHWMRQMPGQGLEWM GAISPRHDITKYNEMFRGQVTISADKSSSTAYLQWSSLKASDTAMYFCA RGGFYGSTIWFDFWGQGTMVTVSS (SEQ ID NO;
32, residues 20-140, inclusive);
or(ii) a sequence of amino acid residues having at least about 80% sequence identity to the amino acid sequence of A(i), above; and B. each light chain comprises a light chain variable domain comprising; (i) a sequence of amino acid residues having an amino acid sequence ETTVTQSPSFLSASVGDRVTITCITTTDIDDDMNWFQQEPG KAPKLLISEGNILRPGVPSRFSSSGYGTDFTLTISKLQPEDF ATYYCLQSDNLPFTFGQGTKLEIK (SEQ ID NO;
33, residues 21-127, inclusive);
or(ii) a sequence of amino acid residues having at least about 80% sequence identity to the amino acid sequence of B(i), above. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
-
Specification