Ultrafiltration Membrane, Device, Bioartificial Organ, And Related Methods
First Claim
Patent Images
1. An ultrafiltration system comprising:
- a) a membrane comprising a plurality of nanofabricated pores having a width less than 20 nanometers;
b) a housing containing said membrane; and
c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to deliver fluid across said membrane.
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Abstract
The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). The present invention further provides nanoporous membranes configured to avoid protein fouling with, for example, a polyethylene glycol surface coating.
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Citations
84 Claims
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1. An ultrafiltration system comprising:
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a) a membrane comprising a plurality of nanofabricated pores having a width less than 20 nanometers; b) a housing containing said membrane; and c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to deliver fluid across said membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An ultrafiltration system comprising:
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a) a membrane comprising a plurality of nanofabricated pores, wherein said membrane has a surface coating selected from the group consisting of polyethylene glycol, oligosaccharide surfactant polymers, heparin, and hyaluronan; b) a housing containing said membrane; and c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to deliver fluid across said membrane. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. An ultrafiltration system comprising:
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a) a membrane comprising a plurality of nanofabricated pores having a width less than 20 nanometers;
said membrane having a surface coating selected from the group consisting of polyethylene glycol, oligosaccharide surfactant polymers, heparin, and hyaluronan;b) a housing containing said membrane and said electrode; and c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to deliver fluid across said membrane. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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45. A method of filtering a biological fluid comprising:
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a) providing; i) a biological fluid; and ii) an ultrafiltration system comprising; a) a membrane comprising a plurality of nanofabricated pores having a width less than 20 nanometers;
said membrane having a surface coating selected from the group consisting of polyethylene glycol, oligosaccharide surfactant polymers, heparin, and hyaluronan;b) a housing containing said membrane and said electrode; and c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to deliver fluid across said membrane; b) transferring said biological fluid into said first end of said delivery passageway; and c) passing said fluid across said membrane to generated filtered fluid. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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59. An implantable ultrafiltration device comprising:
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a) a membrane comprising a plurality of nanofabricated pores having a width less than 20 nanometers;
said membrane having a surface coating selected from the group consisting of polyethylene glycol, oligosaccharide surfactant polymers, heparin, and hyaluronan;b) a biocompatible housing containing said membrane; and c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to delivery fluid across said membrane. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75)
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- 76. A method of creating an implantable ultrafiltration device comprising adding a plurality of nanofabricated pores having a width of less than 200 nanometers onto the surface of a membrane, wherein said nanofabricated pores are positioned in the center of said membrane surface.
Specification