Identifying Naive, Infected, or Vaccinated Mammals
First Claim
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1. A method for determining the immunological state of a mammal with respect to a pathogen, wherein said method comprises:
- (a) administering, to said mammal, a composition comprising a matrix and an antigen preparation of said pathogen, and(b) determining whether or not said composition attracted a naï
ve infiltrate,wherein the presence of said naï
ve-infiltrate indicates that said mammal is not infected with and not vaccinated against said pathogen, and wherein the absence of said naï
ve-infiltrate indicates that said mammal was vaccinated against said pathogen or is infected with said pathogen.
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Abstract
This document provides methods and materials related to assessing a mammal'"'"'s immunological state. For example, methods and materials related to assessing a mammal to determine whether the mammal is immunologically naïve with respect to a pathogen, was vaccinated against that pathogen, or is infected with that pathogen are provided. This document also provides methods and materials that can be used to determine whether or not a mammal (e.g., a cow) has an early stage infection (e.g., stage 1, Johne'"'"'s disease).
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Citations
20 Claims
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1. A method for determining the immunological state of a mammal with respect to a pathogen, wherein said method comprises:
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(a) administering, to said mammal, a composition comprising a matrix and an antigen preparation of said pathogen, and (b) determining whether or not said composition attracted a naï
ve infiltrate,wherein the presence of said naï
ve-infiltrate indicates that said mammal is not infected with and not vaccinated against said pathogen, and wherein the absence of said naï
ve-infiltrate indicates that said mammal was vaccinated against said pathogen or is infected with said pathogen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A delivery system for determining the immunological state of a mammal with respect to a pathogen, wherein said delivery system comprises an injecting device configured to inject an implantation device into said mammal, a cartridge configured to engage said injecting device such that an implantation device located in said cartridge can be injected into said mammal, and a plurality of implantation devices located in said cartridge, wherein each of said plurality of implantation devices comprise a cell permeable housing and a composition located within said housing, wherein said composition comprises a matrix and an antigen preparation of said pathogen.
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15. A kit for determining the immunological state of a mammal with respect to a pathogen, wherein said kit comprises:
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(a) an implantation device comprising a cell permeable housing and a composition located within said housing, wherein said composition comprises a matrix and an antigen preparation of said pathogen, and (b) a detection device comprising an antibody for detecting a cytokine or an inflammatory cell. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification