GENERATION AND ISOLATION OF ANTIGEN-SPECIFIC T CELLS
First Claim
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1. A method for generating and/or enriching antigen-specific T cells comprising:
- (a) exposing a first population of cells wherein at least a portion thereof comprises antigen presenting cells to a surface wherein said surface has antigen attached thereto, such that said surface with antigen attached thereto is ingested by said APC;
(b) exposing a second population of cells wherein at least a portion thereof comprises T cells to the population of cells in part (a);
thereby generating and/or enriching antigen-specific T cells.
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Abstract
The present invention relates generally to methods for generating, expanding, and isolating antigen-specific T cells. Compositions of antigen-specific T cells activated and expanded by the methods herein are further provided.
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Citations
16 Claims
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1. A method for generating and/or enriching antigen-specific T cells comprising:
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(a) exposing a first population of cells wherein at least a portion thereof comprises antigen presenting cells to a surface wherein said surface has antigen attached thereto, such that said surface with antigen attached thereto is ingested by said APC; (b) exposing a second population of cells wherein at least a portion thereof comprises T cells to the population of cells in part (a); thereby generating and/or enriching antigen-specific T cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification