GLUCAGON ANALOGS EXHIBITING PHYSIOLOGICAL SOLUBILITY AND STABILITY
First Claim
Patent Images
1. A glucagon peptide, wherein the side chain of one or two amino acid residues at positions 16, 17, 20, 21, 24, and/or 29, of said glucagon peptide further comprises a hydrophilic moiety covalently bound to the amino acid residue, and pharmaceutically acceptable salts of said glucagon peptide.
1 Assignment
0 Petitions
Accused Products
Abstract
Modified glucagon peptides are disclosed having improved solubility and stability, wherein the native glucagon peptide has been modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, or both.
-
Citations
57 Claims
- 1. A glucagon peptide, wherein the side chain of one or two amino acid residues at positions 16, 17, 20, 21, 24, and/or 29, of said glucagon peptide further comprises a hydrophilic moiety covalently bound to the amino acid residue, and pharmaceutically acceptable salts of said glucagon peptide.
-
2. (canceled)
-
3. (canceled)
-
5. (canceled)
-
6. (canceled)
-
10. (canceled)
-
12. (canceled)
-
13. (canceled)
-
15-17. -17. (canceled)
-
19-28. -28. (canceled)
-
30-33. -33. (canceled)
-
35. (canceled)
-
36. (canceled)
-
38. (canceled)
-
40. (canceled)
-
42-46. -46. (canceled)
Specification