Novel Compounds
First Claim
Patent Images
1. A compound of the formula:
- whereinR1 is an optionally substituted aryl or an optionally substituted heteroaryl ring;
R2 and R2′
are independently selected from hydrogen, C1-10 alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-10alkyl, C5-7 cycloalkenyl, C5-7 cycloalkenyl-C1-10alkyl, aryl, arylC1-10 alkyl, heteroaryl, heteroarylC1-10 alkyl, heterocyclic, or a heterocyclylC1-10 alkyl moiety, wherein all of the moieties are optionally substituted, or R2 and R2′
together with the nitrogen to which they are attached form a 5 to 7 membered optionally substituted ring, which ring may contain an additional heteroatom selected from O/N/S;
Ra is hydrogen, or an optionally substituted C1-4 alkyl;
Rg is selected from an optionally substituted C1-10 alkyl, —
CH2—
CH2—
O—
CH2—
CH2—
, —
CH2—
C(O)—
CH2, CH2—
C(O)N(R12)CH2—
CH2—
, CH2—
N(R12)C(O)CH2—
, CH2—
CH(OR12)—
CH2, CH2—
C(O)O—
CH2—
CH2, or CH2—
CH2—
O—
C(O)CH2—
;
R12 is hydrogen, or an optionally substituted C1-4 alkyl;
R3 is a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkylC1-4alkyl, aryl, arylC1-10 alkyl, heteroaryl, heteroarylC1-10 alkyl, heterocyclic, or a heterocyclylC1-10 alkyl moiety, which moieties are all optionally substituted;
Y is C(R13′
)(R16′
), C(O), N(R16), N(R17′
)C(R15′
)(R16′
), oxygen OC(R15′
)(R16′
), S(O)m, or S(O)mC(R15′
)(R16′
);
R13′
is hydrogen C1-2 alkyl N(R18′
)2, hydroxy, thio, C1-2 alkoxy, or S(O)mC1-2alkyl;
R15′
is hydrogen or C1-2 alkylR16′
is hydrogen or C1-2 alkydR17′
is hydrogen or C1-2 alkylR18′
is independently selected at each occurrence from hydrogen or C1-2 alkylm is independently selected at each occurrence from 0 or an integer having a value of 1 or 2; and
a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof.
1 Assignment
0 Petitions
Accused Products
Abstract
This invention relates to a novel group of 8-Alkyl/Aryl-4-aryl-2-N-(alkylamino)-N″-substituted-N′-cyanoguanidino-8H-pyrido[2,3-d]pyrimidin-7-one compounds, processes for the preparation thereof, the use thereof in treating CSBP/p38 kinase mediated diseases and pharmaceutical compositions for use in such therapy.
53 Citations
28 Claims
-
1. A compound of the formula:
-
wherein R1 is an optionally substituted aryl or an optionally substituted heteroaryl ring; R2 and R2′
are independently selected from hydrogen, C1-10 alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-10alkyl, C5-7 cycloalkenyl, C5-7 cycloalkenyl-C1-10alkyl, aryl, arylC1-10 alkyl, heteroaryl, heteroarylC1-10 alkyl, heterocyclic, or a heterocyclylC1-10 alkyl moiety, wherein all of the moieties are optionally substituted, or R2 and R2′
together with the nitrogen to which they are attached form a 5 to 7 membered optionally substituted ring, which ring may contain an additional heteroatom selected from O/N/S;Ra is hydrogen, or an optionally substituted C1-4 alkyl; Rg is selected from an optionally substituted C1-10 alkyl, —
CH2—
CH2—
O—
CH2—
CH2—
, —
CH2—
C(O)—
CH2, CH2—
C(O)N(R12)CH2—
CH2—
, CH2—
N(R12)C(O)CH2—
, CH2—
CH(OR12)—
CH2, CH2—
C(O)O—
CH2—
CH2, or CH2—
CH2—
O—
C(O)CH2—
;R12 is hydrogen, or an optionally substituted C1-4 alkyl; R3 is a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkylC1-4alkyl, aryl, arylC1-10 alkyl, heteroaryl, heteroarylC1-10 alkyl, heterocyclic, or a heterocyclylC1-10 alkyl moiety, which moieties are all optionally substituted; Y is C(R13′
)(R16′
), C(O), N(R16), N(R17′
)C(R15′
)(R16′
), oxygen OC(R15′
)(R16′
), S(O)m, or S(O)mC(R15′
)(R16′
);R13′
is hydrogen C1-2 alkyl N(R18′
)2, hydroxy, thio, C1-2 alkoxy, or S(O)mC1-2alkyl;R15′
is hydrogen or C1-2 alkylR16′
is hydrogen or C1-2 alkydR17′
is hydrogen or C1-2 alkylR18′
is independently selected at each occurrence from hydrogen or C1-2 alkylm is independently selected at each occurrence from 0 or an integer having a value of 1 or 2; and
a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 24, 25, 26, 27, 28)
-
-
18. (canceled)
-
22. (canceled)
-
23. (canceled)
Specification