METHODS AND APPARATUS FOR REPEATED ISCHEMIC CONDITIONING TREATMENT OF HYPERTENSION AND OTHER MEDICAL CONDITIONS

• US 20090137884A1
• Filed: 11/25/2008
• Published: 05/28/2009
• Est. Priority Date: 11/25/2007
• Status: Active Grant

• Current Assignee: American Heart Technologies, LLC
• Original Assignee: IC Therapeutics, Inc.
• Inventors: Naghavi, Morteza, Yen, Albert Andrew, Hassan, Haider, Panthagani, David
• Granted Patent: US 8,986,342 B2
• Time in Patent Office: Days
• US Class Current: 600/309
• CPC Class Codes: A61B 17/135 inflatable for measuring blood pressure A61B5/022; inflatable pressure pads A61F5/34
• CPC Class Codes: A61B 17/1355 Automated control means therefor
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/417 the bone marrow

Abstract

Methods for ischemic conditioning treatments of a chronic medical condition are provided. Baseline disease-related parameters of a patient with a chronic medical condition are measured. Ischemia is induced in the patient by occluding and releasing arterial flow in one or more extremities of the patient. Post-ischemia parameters in the patient are measured. The baseline and post-ischemia parameters are compared to provide an assessment of an ischemic conditioning treatment of a chronic medical condition. The repeated, scheduled delivery of ischemic conditioning provides a beneficial, therapeutic effect on the chronic medical condition. Also provided is a device for pulse oximetry during periods of absent or low pulsatile blood flow including an artificial pulse generator as well as the use of said device in assessment of ischemic conditioning.

Claims

1. A method for modulating a vascular condition by administering a program of ischemic conditioning.

2. The method of claim 1, wherein the program of ischemic conditioning comprises at least 1 cycle of from 1 to 20 minutes of occlusion on at least one extremity, at least 2-4 times per week.

3. The method of claim 2, wherein the program of ischemic conditioning comprises at least 1 cycle of from about 2 to about 5 minutes of occlusion.

4. The method of claim 2, wherein the program of ischemic conditioning comprises plurality of cycles of occlusion followed by release according to a schedule implemented to maximize lowering of blood pressure in an individual patient.

5. The method of claim 1 wherein the program of ischemic conditioning comprises at least 2 cycles of about 2 to about 5 minutes of occlusion followed by about 2 to about 5 minutes of release of an extremity at least 2-4 times per week.

6. The method of claim 1, wherein the vascular condition is selected from the group consisting of:

hypertension, Raynaud'"'"'s syndrome, coronary heart disease (CHD), coronary artery disease (CAD), peripheral arterial disease (PAD), diabetes, pulmonary hypertension (PH), and connective tissue disorders.

7. A method of claim 1, wherein the vascular condition is a starting vascular condition of an athlete and the program of ischemic conditioning is administered on a repeated, scheduled basis adapted to improved endurance and athletic performance.

8. The method of claim 1, wherein the ischemic conditioning is applied to one or more extremities using an external cuff system for arterial occlusion.

9. The method of claim 1, wherein the ischemic conditioning is applied to one or more extremities using external pressure to the skin using a pressurizable garment.

10. The method of claim 1, further comprising measurement of blood oxygen saturation during ischemia using artificial pulse together with oximetry to improve the ischemic conditioning treatments.

11. The method of claim 10, wherein the artificial pulse is generated by mechanical actuation.

12. The method of claim 11, wherein the mechanical actuation is effected by pulsating fluid pressure in a cuff to cause mechanical disturbance of arterial blood, repetitive, external electromechanical actuation, or repetitive, self-induced physical motion.

13. The method of claim 10, wherein the artificial pulse is generated by external non-mechanical optical illumination utilized to imitate an absorption pattern of a pulsatile blood flow signal by oscillating an intensity of a light source of either a single or multiple wave length.

14. A method for assessing an ischemic conditioning treatment comprising:

measuring one or more baseline hemodynamic parameters of a patient,

applying an ischemic conditioning treatment in the patient by occluding and releasing arterial flow in one or more extremities of the patient on a scheduled, repeated basis,

measuring post-ischemia parameters in the patient, and

comparing the baseline and post-ischemia parameters to provide an assessment of the ischemic conditioning treatment over time.

15. The method of claim 14, further comprising measuring blood oxygen saturation during ischemia using an artificial pulse together with oximetry to improve assessment of the ischemic conditioning treatments.

16. The method of claim 15, wherein the artificial pulse is generated by mechanical actuation.

17. The method of claim 16, wherein the mechanical actuation is effected by pulsating fluid pressure in a cuff to cause mechanical disturbance of arterial blood, repetitive, external electromechanical actuation, or repetitive, self-induced physical motion.

18. The method of claim 15, wherein the artificial pulse is generated by external non-mechanical optical illumination utilized to imitate the absorption patterns of a pulsatile blood flow signal by oscillating the intensity of a light source of either a single or multiple wave length.

19. The method of claim 14, wherein the treatment is for a condition selected from the group consisting of:

hypertension, pulmonary hypertension (PH), Raynaud'"'"'s syndrome, coronary heart disease (CHD), coronary artery disease (CAD), peripheral arterial disease (PAD), diabetes, and connective tissue disorders.

20. A device for monitoring blood oxygenation during periods of absent or low pulsatile blood flow comprising:

a pulse oximeter, and

an artificial pulse generator, wherein the pulse oximeter is adapted to measure blood oxygenation in an artificial pulse created by the artificial pulse generator.

21. The device of claim 20, wherein the artificial pulse is generated by mechanical actuation.

22. The device of claim 21, wherein the mechanical actuation is effected by pulsating fluid pressure in a cuff to cause mechanical disturbance of arterial blood, repetitive, external electromechanical actuation, or repetitive, self-induced physical motion.

23. The device of claim 20 wherein the artificial pulse is generated by external non-mechanical optical illumination utilized to imitate the absorption patterns of a pulsatile blood flow signal by oscillating the intensity of a light source of either a single or multiple wave length.