Subcutaneous Glucose Electrode
First Claim
1. An analyte sensor comprising:
- one or more working electrodes; and
an analyte-responsive sensing layer associated with and in electrical contact with the one or more working electrodes, the sensing layer comprising an enzyme,wherein at least a portion of the sensor is adapted to be subcutaneously positioned in a subject.
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Accused Products
Abstract
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer can be overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited. An outer layer is preferably biocompatible.
52 Citations
20 Claims
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1. An analyte sensor comprising:
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one or more working electrodes; and an analyte-responsive sensing layer associated with and in electrical contact with the one or more working electrodes, the sensing layer comprising an enzyme, wherein at least a portion of the sensor is adapted to be subcutaneously positioned in a subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 18, 19, 20)
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16. An analyte sensor comprising:
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an electrode comprising a metal wire; and an analyte-responsive sensing layer associated with the wire, the sensing layer comprising an enzyme. - View Dependent Claims (17)
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Specification